Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Hypercalcemia and Primary Hepatic Tumors

Hypercalcemia and Primary Hepatic Tumors Abstract • We treated a case of hypercalcemia and primary liver tumor and reviewed a series of such cases treated at the Mayo Clinic (Rochester, Minn). Primary tumor of the liver was diagnosed in 192 patients (152 had hepatocellular carcinomas; 40, cholangiocarcinomas) between 1969 and 1980. Hypercalcemia of unknown cause was found in eight patients with hepatocellular carcinoma (5.3%) and seven with cholangiocarcinoma (17.5%). Five hypercalcemic patients had serum immunoreactive parathyroid hormone values consistent with ectopic hyperparathyroidism. An additional five patients had high serum calcium, low phosphate, and low chloride concentrations that met Lafferty's criteria for pseudohyperparathyroidism. Our results suggest that hypercalcemia associated with primary hepatic tumors is relatively common, and incidences vary according to the type of primary tumor. Hypercalcemia may be controlled when surgical excision of the primary tumor is possible. (Arch Surg 1982;117:1363-1366) References 1. Fry L: Pseudohyperparathyroidism with carcinoma of bronchus . Br Med J 1962;1:301-302.Crossref 2. Lafferty FW: Pseudohyperparathyroidism . Medicine 1966;45:247-260.Crossref 3. Silverberg E: Cancer statistics, 1979 . CA 1979;29:6-21. 4. Parker JC Jr, Dahlin DC, Stauffer MH: Malignant hepatoma: Evaluation of surgical (including needle biopsy) material from 69 cases . Mayo Clin Proc 1970;45:25-35. 5. Ihde DC, Sherlock P, Winawer SJ, et al: Clinical manifestations of hepatoma: A review of six years' experience at a cancer hospital . Am J Med 1974;56:83-91.Crossref 6. Adson MA, Weiland LH: Resection of primary solid hepatic tumors . Am J Surg 1981;141:18-20.Crossref 7. Burt ME, Brennan MF: Incidence of hypercalcemia and malignant neoplasm . Arch Surg 1980;115:704-707.Crossref 8. Omata M, Peters RL, Tatter D: Sclerosing hepatic carcinoma: Relationship to hypercalcemia , abstracted. Gastroenterology 1979;77:31. 9. Polterauer P, Kovarik J, Ulrich W: Hyperkalzämie bei Lebertumoren . Wien Klin Wochenschr 1980:92:689-693. 10. Berson SA, Yalow RS: Parathyroid hormone in plasma in adenomatous hyperparathyroidism, uremia, and bronchogenic carcinoma . Science 1966;154:907-909.Crossref 11. Demers LM, Allegra JC, Harvey HA, et al: Plasma prostaglandins in hypercalcemic patients with neoplastic disease . Cancer 1977;39:1559-1562.Crossref 12. Seyberth HW, Segre GV, Morgan JL, et al: Prostaglandins as mediators of hypercalcemia associated with certain types of cancer . N Engl J Med 1975;293:1278-1283.Crossref 13. Mundy GR, Raisz LG, Cooper RA, et al: Evidence for the secretion of an osteoclast stimulating factor in myeloma . N Engl J Med 1974;291:1041-1046.Crossref 14. Knill-Jones RP, Buckle RM, Parsons V, et al: Hypercalcemia and increased parathyroid-hormone activity in a primary hepatoma: Studies before and after hepatic transplantation . N Engl J Med 1970;282:704-708.Crossref 15. Omenn GS, Roth SI, Baker WH: Hyperparathyroidism associated with malignant tumors of nonparathyroid origin . Cancer 1969;24:1004-1012.Crossref 16. Roche A, Franco D, Dhumeaux D, et al: Emergency hepatic arterial embolization for secondary hypercalcemia in hepatocellular carcinoma . Radiology 1979;133:315-316.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Loading next page...
 
/lp/american-medical-association/hypercalcemia-and-primary-hepatic-tumors-fDuYZ5ysXg
Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1982.01380340077018
Publisher site
See Article on Publisher Site

Abstract

Abstract • We treated a case of hypercalcemia and primary liver tumor and reviewed a series of such cases treated at the Mayo Clinic (Rochester, Minn). Primary tumor of the liver was diagnosed in 192 patients (152 had hepatocellular carcinomas; 40, cholangiocarcinomas) between 1969 and 1980. Hypercalcemia of unknown cause was found in eight patients with hepatocellular carcinoma (5.3%) and seven with cholangiocarcinoma (17.5%). Five hypercalcemic patients had serum immunoreactive parathyroid hormone values consistent with ectopic hyperparathyroidism. An additional five patients had high serum calcium, low phosphate, and low chloride concentrations that met Lafferty's criteria for pseudohyperparathyroidism. Our results suggest that hypercalcemia associated with primary hepatic tumors is relatively common, and incidences vary according to the type of primary tumor. Hypercalcemia may be controlled when surgical excision of the primary tumor is possible. (Arch Surg 1982;117:1363-1366) References 1. Fry L: Pseudohyperparathyroidism with carcinoma of bronchus . Br Med J 1962;1:301-302.Crossref 2. Lafferty FW: Pseudohyperparathyroidism . Medicine 1966;45:247-260.Crossref 3. Silverberg E: Cancer statistics, 1979 . CA 1979;29:6-21. 4. Parker JC Jr, Dahlin DC, Stauffer MH: Malignant hepatoma: Evaluation of surgical (including needle biopsy) material from 69 cases . Mayo Clin Proc 1970;45:25-35. 5. Ihde DC, Sherlock P, Winawer SJ, et al: Clinical manifestations of hepatoma: A review of six years' experience at a cancer hospital . Am J Med 1974;56:83-91.Crossref 6. Adson MA, Weiland LH: Resection of primary solid hepatic tumors . Am J Surg 1981;141:18-20.Crossref 7. Burt ME, Brennan MF: Incidence of hypercalcemia and malignant neoplasm . Arch Surg 1980;115:704-707.Crossref 8. Omata M, Peters RL, Tatter D: Sclerosing hepatic carcinoma: Relationship to hypercalcemia , abstracted. Gastroenterology 1979;77:31. 9. Polterauer P, Kovarik J, Ulrich W: Hyperkalzämie bei Lebertumoren . Wien Klin Wochenschr 1980:92:689-693. 10. Berson SA, Yalow RS: Parathyroid hormone in plasma in adenomatous hyperparathyroidism, uremia, and bronchogenic carcinoma . Science 1966;154:907-909.Crossref 11. Demers LM, Allegra JC, Harvey HA, et al: Plasma prostaglandins in hypercalcemic patients with neoplastic disease . Cancer 1977;39:1559-1562.Crossref 12. Seyberth HW, Segre GV, Morgan JL, et al: Prostaglandins as mediators of hypercalcemia associated with certain types of cancer . N Engl J Med 1975;293:1278-1283.Crossref 13. Mundy GR, Raisz LG, Cooper RA, et al: Evidence for the secretion of an osteoclast stimulating factor in myeloma . N Engl J Med 1974;291:1041-1046.Crossref 14. Knill-Jones RP, Buckle RM, Parsons V, et al: Hypercalcemia and increased parathyroid-hormone activity in a primary hepatoma: Studies before and after hepatic transplantation . N Engl J Med 1970;282:704-708.Crossref 15. Omenn GS, Roth SI, Baker WH: Hyperparathyroidism associated with malignant tumors of nonparathyroid origin . Cancer 1969;24:1004-1012.Crossref 16. Roche A, Franco D, Dhumeaux D, et al: Emergency hepatic arterial embolization for secondary hypercalcemia in hepatocellular carcinoma . Radiology 1979;133:315-316.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Oct 1, 1982

References