Abstract To the Editor.— In their excellent review article Tanenbaum and Tuffanelli1 mention pregnancy as a contraindication to the use of chloroquine phosphate.I have been involved with this problem with one patient, a 23-year-old woman who was taking 200 mg/day of hydroxychloroquine sulfate during the first 16 weeks of pregnancy as a therapy for discoid lupus erythematosus. The pregnancy was allowed to proceed to full term. A healthy male infant was born. Follow-up examinations for two years have not shown any abnormality in the child's mental or physical development.Hart and Naunton2 have described one family in which the mother had been taking chloroquine on and off, in excess of the recommended dose, for more than six years. Of a total of seven pregnancies, she had taken the drug during part or all of four of the pregnancies. These four pregnancies resulted in one miscarriage and three children References 1. Tanenbaum L, Tuffanelli DL: Antimalarial agents: Chloroquine, hydroxychloroquine, and quinacrine . Arch Dermatol 1980;116:587-591.Crossref 2. Hart CW, Naunton RF: The ototoxicity of chloroquine phosphate . Arch Otolaryngol 1964;80:407-412.Crossref 3. Lewis R, Laversen NH, Birnbaum S: Malaria associated with pregnancy . Obstet Gynecol 1973;42:696-700.
Archives of Dermatology – American Medical Association
Published: Mar 1, 1983