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Hyaline Bodies of Ganglion-Cell Origin in the Human Retina

Hyaline Bodies of Ganglion-Cell Origin in the Human Retina Abstract In earlier studies my co-workers and I were able to demonstrate that hyaline bodies (corpora amylacea) of the human retina and optic nerve are a rather nonspecific finding. They may develop in senescense and under pathologic conditions from continuous or interrupted degenerating neurites (nerve fibers).1-5 Very similar bodies are found as a result of degeneration of retinal astroglia,6 perivascular glia,7 or ganglion cells8 under severe pathologic conditions. They may also occur as the final stage of hyalinization of microaneurysms in diabetic retinopathy.2,9 The hyaline bodies of these different origins look histologically very much alike. They all are eosinophilic and may show a distinct lamellation. This latter fact gives them sometimes a cell-like appearance. It is the purpose of this paper to describe a case which exhibits all stages of a hitherto unknown type of hyaline body formation by slow degeneration of certain ganglion cells of References 1. Wolter, J. R.; Goldsmith, R. I., and Phillips, R. L.: Histopathology of the Star-Figure of the Macular Area in Diabetic and Angiospastic Retinopathy , A. M. A. Arch. Ophth. 57:376, 1957.Crossref 2. Wolter, J. R.: Reactions of the Elements of Retina and Optic Nerve: In Common Morbid Entities of the Human Eye , Am. J. Ophth. 42:10 (Oct., (Pt. 2) ) 1956. 3. Wolter, J. R., and Liss, L: The Evolution of Hyaline Corpuscles (Cytoid Bodies) in the Human Optic Nerve , Am. J. Ophth. 43:885, 1957. 4. Wolter, J. R.: The Human Optic Papilla: A Demonstration of New Anatomic and Pathologic Findings , Am. J. Ophth. 44:48 (Oct., (Pt. 2) ) 1957. 5. Wolter, J. R., and Liss, L.: Hyaline Bodies of the Human Optic Nerve, to be published. 6. Wolter, J. R.: Retinitis Pigmentosa , A. M. A. Arch. Ophth. 57:539, 1957.Crossref 7. Wolter, J. R., and Wilson, W. W.: Degeneration of the Peripheral Retina, Am. J. Ophth., to be published. 8. Wolter, J. R.: Secondary Degeneration of the Human Retina , A. M. A. Arch. Ophth. 59:731, 1958.Crossref 9. Wolter, J. R.: Ein Beitrag zur Pathologie der Augenveränderungen beim Diabetes , Klin. Monatsbl. Augenh. 129:505, 1956. 10. Scharenberg, K., and Zeman, W.: Zur Leistungsfähigkeit und zur Technik der Hortega'schen Silberkarbonatmethoden , Ztschr. Psychiat. 188:430, 1952. 11. Wolter, J. R., and Henderson, J. W.: Cornea guttata , Klin. Monatsbl. Augenh. 131:725, 1951. 12. Wolter, J. R.; Henderson, J. W., and Gates, K.: Endothelial and Epithelial Dystrophy of the Cornea , Am. J. Ophth. 44:191, 1957. 13. Chi, H. H.; Teng, C. C., and Katzin, H. M.: Dystrophy of the Cornea , Am. J. Ophth. 45:818, 1958. 14. Friedenwald, J. S., et al.: Ophthalmic Pathology: An Atlas and Text Book , Philadelphia, W. B. Saunders Company, 1952. 15. Wolter, J. R.: Über besondere Astroglia an der Innenfläche der Retina , Klin. Monatsbl. Augenh. 129:224, 1956. 16. Rones, B.: Formation of Drusen of the Lamina Vitrea , Transactions of the A. M. A. Section on Ophthalmology , 1937, p. 165. 17. Wolter, J. R.: Die Histogenese der Drusen im Pigmentepithel der Netzhaut des menschlichen Auges , Klin. Monatsbl. Augenh. 130:86, 1957. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Ophthalmology American Medical Association

Hyaline Bodies of Ganglion-Cell Origin in the Human Retina

A.M.A. Archives of Ophthalmology , Volume 61 (1) – Jan 1, 1959

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Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0096-6339
DOI
10.1001/archopht.1959.00940090129018
Publisher site
See Article on Publisher Site

Abstract

Abstract In earlier studies my co-workers and I were able to demonstrate that hyaline bodies (corpora amylacea) of the human retina and optic nerve are a rather nonspecific finding. They may develop in senescense and under pathologic conditions from continuous or interrupted degenerating neurites (nerve fibers).1-5 Very similar bodies are found as a result of degeneration of retinal astroglia,6 perivascular glia,7 or ganglion cells8 under severe pathologic conditions. They may also occur as the final stage of hyalinization of microaneurysms in diabetic retinopathy.2,9 The hyaline bodies of these different origins look histologically very much alike. They all are eosinophilic and may show a distinct lamellation. This latter fact gives them sometimes a cell-like appearance. It is the purpose of this paper to describe a case which exhibits all stages of a hitherto unknown type of hyaline body formation by slow degeneration of certain ganglion cells of References 1. Wolter, J. R.; Goldsmith, R. I., and Phillips, R. L.: Histopathology of the Star-Figure of the Macular Area in Diabetic and Angiospastic Retinopathy , A. M. A. Arch. Ophth. 57:376, 1957.Crossref 2. Wolter, J. R.: Reactions of the Elements of Retina and Optic Nerve: In Common Morbid Entities of the Human Eye , Am. J. Ophth. 42:10 (Oct., (Pt. 2) ) 1956. 3. Wolter, J. R., and Liss, L: The Evolution of Hyaline Corpuscles (Cytoid Bodies) in the Human Optic Nerve , Am. J. Ophth. 43:885, 1957. 4. Wolter, J. R.: The Human Optic Papilla: A Demonstration of New Anatomic and Pathologic Findings , Am. J. Ophth. 44:48 (Oct., (Pt. 2) ) 1957. 5. Wolter, J. R., and Liss, L.: Hyaline Bodies of the Human Optic Nerve, to be published. 6. Wolter, J. R.: Retinitis Pigmentosa , A. M. A. Arch. Ophth. 57:539, 1957.Crossref 7. Wolter, J. R., and Wilson, W. W.: Degeneration of the Peripheral Retina, Am. J. Ophth., to be published. 8. Wolter, J. R.: Secondary Degeneration of the Human Retina , A. M. A. Arch. Ophth. 59:731, 1958.Crossref 9. Wolter, J. R.: Ein Beitrag zur Pathologie der Augenveränderungen beim Diabetes , Klin. Monatsbl. Augenh. 129:505, 1956. 10. Scharenberg, K., and Zeman, W.: Zur Leistungsfähigkeit und zur Technik der Hortega'schen Silberkarbonatmethoden , Ztschr. Psychiat. 188:430, 1952. 11. Wolter, J. R., and Henderson, J. W.: Cornea guttata , Klin. Monatsbl. Augenh. 131:725, 1951. 12. Wolter, J. R.; Henderson, J. W., and Gates, K.: Endothelial and Epithelial Dystrophy of the Cornea , Am. J. Ophth. 44:191, 1957. 13. Chi, H. H.; Teng, C. C., and Katzin, H. M.: Dystrophy of the Cornea , Am. J. Ophth. 45:818, 1958. 14. Friedenwald, J. S., et al.: Ophthalmic Pathology: An Atlas and Text Book , Philadelphia, W. B. Saunders Company, 1952. 15. Wolter, J. R.: Über besondere Astroglia an der Innenfläche der Retina , Klin. Monatsbl. Augenh. 129:224, 1956. 16. Rones, B.: Formation of Drusen of the Lamina Vitrea , Transactions of the A. M. A. Section on Ophthalmology , 1937, p. 165. 17. Wolter, J. R.: Die Histogenese der Drusen im Pigmentepithel der Netzhaut des menschlichen Auges , Klin. Monatsbl. Augenh. 130:86, 1957.

Journal

A.M.A. Archives of OphthalmologyAmerican Medical Association

Published: Jan 1, 1959

References