Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Human T-Cell Lymphotropic Virus Type I—Associated Retinal Lymphoma: A Clinicopathologic Report

Human T-Cell Lymphotropic Virus Type I—Associated Retinal Lymphoma: A Clinicopathologic Report Abstract Human T-cell lymphotropic virus type I has been associated with a wide range of ocular conditions, including neoplastic, infectious, and inflammatory lesions. We studied a patient infected with human T-cell lymphotropic virus type I who presented with deep retinal and subretinal infiltrates but without cells in the vitreous. The differential diagnosis included intraocular lymphoma and fungus infection. A chorioretinal biopsy specimen obtained for tissue diagnosis disclosed large atypical mononuclear cells located primarily at the level of the retinal pigment epithelium but focally involving overlying retina. Electron microscopy of this infiltrate showed features consistent with adult T-cell lymphoma/leukemia. Infection by human T-cell lymphotropic virus type I was verified by polymerase chain reaction studies conducted on peripheral-blood mononuclear cells. This case emphasizes the occurrence of intraocular lesions in adult T-cell lymphoma/leukemia that clinically show some features similar to those of the usual ocular lymphoma (reticulum cell sarcoma); diagnosis can be established by chorioretinal biopsy, thereby allowing appropriate therapy. References 1. Blattner WA. Epidemiology of HTLV-I and associated diseases . In: Blattner WA, ed. Human Retrovirology: HTLV . New York, NY: Raven Press; 1990:251-265. 2. Yoshida M, Seiki M, Yamaguchi K, Takatsuki K. Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease . Proc Natl Acad Sci U S A . 1984;81:2534-2537.Crossref 3. Osame M, Usuku K, Izumo S, et al. HTLV1 associated myelopathy, a new clinical entity . Lancet . 1986;1:1031-1032.Crossref 4. Lauer SA, Fischer J, Jones J, Gartner S, Dutcher J, Hoxie JA. Orbital T-cell lymphoma in human T-cell leukemia virus-I infection . Ophthalmology . 1988;95:110-115.Crossref 5. Hayasaka S, Takatori Y, Noda S, Setogawa T, Hayashi H. Retinal vasculitis in a mother and her son with human T-lymphotropic virus type 1 associated myelopathy . Br J Ophthalmol . 1991;75:566-567.Crossref 6. Ohba N, Matsumoto M, Sameshima M, et al. Ocular manifestations in patients infected with human T-lymphotropic virus type I . Jpn J Ophthalmol . 1989;33:1-12. 7. Mochizuki M, Watanabe T, Yamaguchi K, et al. Uveitis associated with human T-cell lymphotropic virus type I . Am J Ophthalmol . 1992;114:123-129. 8. Meyer RD, Moudgil T, Detels R, Phair JY, Hirsch MS, Ho DD. Seroprevalence of human T cell leukemia viruses in selected populations of homosexual men . J Infect Dis . 1990;162:1370-1372.Crossref 9. Gill PS, Masood R, Cai J, et al. Novel (antiviral) therapy for adult T-cell leukemia secondary to HTLV-I infection . Blood . 1992;80( (suppl 1) ):74a. Abstract. 10. Uchiyama T, Yodoi J, Sagawa K, et al. Adult T-cell leukemia: clinical and hematologic features of 16 cases . Blood . 1977;50:481-492. 11. Inomata H, Kohno T. A case of adult T-cell leukemia (ATL) with ocular involvement. Read before the International Uveitis Study Group Meeting; Pasadena, Calif; October 17, 1991. 12. Lewis H, Schachat AP. Non-Hodgkin's ('reticulum cell') lymphoma . In: Ryan SJ, ed. Retina . St Louis, Mo: CV Mosby Co; 1989;1:795-804. 13. Char DH, Margolis L, Newman AB. Ocular reticulum cell sarcoma . Am J Ophthalmol . 1981;91:480-483. 14. Shields JA, Shields CL. Intraocular Tumors: A Text and Atlas . Philadelphia, Pa: WB Saunders Co; 1992:498-504. 15. Freeman LN, Schachat AP, Knox DL, Michels RG, Green WR. Clinical features, laboratory investigations, and survival in ocular reticulum cell sarcoma . Ophthalmology . 1987;94:1631-1639.Crossref 16. Gass JDM, Sever RJ, Grizzard WS, et al. Multifocal pigment epithelial detachments by reticulum cell sarcoma: a characteristic funduscopic picture . Retina . 1984;4:135-143.Crossref 17. Green WR. Systemic diseases with retinal involvement . In: Spencer WH, ed. Ophthalmic Pathology: An Atlas and Textbook , 3rd ed. Philadelphia, Pa: WB Saunders Co; 1985:1064-1071, 1588-1591, 1656-1673. 18. Kikuchi M, Mitsui T, Takeshita M, et al. Virus associated adult T-cell leukemia (ATL) in Japan: clinical, histological and immunological studies . Hematol Oncol . 1986;4:67-81.Crossref 19. Jones SE, Fuks Z, Bull M, et al. Non-Hodgkin's lymphomas, IV: clinicopathologic correlation in 405 cases . Cancer . 1973;31:806-823.Crossref 20. Portlock CS. The non-Hodgkin's lymphomas . In: Wyngaarden JB, Smith LH, eds. Cecil Textbook of Medicine . Philadelphia, Pa: WB Saunders Co; 1988:1009-1013. 21. Kaplan HJ, Meredith TA, Aaberg TM, Keller RH. Reclassification of intraocular reticulum cell sarcoma (histiocytic lymphoma): immunologic characterization of vitreous cells . Arch Ophthalmol . 1980;98:707-710.Crossref 22. Kirmani MH, Thomas EL, Rao NA, Laborde RP. Intraocular reticulum cell sarcoma: diagnosis by choroidal biopsy . Br J Ophthalmol . 1987;71:748-752.Crossref 23. Parver LM, Font RL. Malignant lymphoma of the retina and brain: initial diagnosis by cytologic examination of vitreous aspirate . Arch Ophthalmol . 1979;97:1505-1507.Crossref 24. Engel HM, Green WR, Michels RG, Rice TA, Erozan YS. Diagnostic vitrectomy . Retina . 1981;1:121-149.Crossref 25. Yamaguchi K, Nishimura Y, Kawano F, et al. A proposal for smoldering adult T-cell leukemia: diversity in clinical pictures of adult T-cell leukemia . Jpn J Clin Oncol . 1983;13:189-200. 26. Yodoi J, Uchiyama T. Diseases associated with HTLV-I: virus, IL-2 receptor dysregulation and redox regulation . Immunol Today . 1992;13:405-410.Crossref 27. Char DH, Ljung BM, Miller T, Phillips T. Primary intraocular lymphoma (ocular reticulum cell sarcoma) diagnosis and management . Ophthalmology . 1988;95:625-630.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Human T-Cell Lymphotropic Virus Type I—Associated Retinal Lymphoma: A Clinicopathologic Report

Loading next page...
 
/lp/american-medical-association/human-t-cell-lymphotropic-virus-type-i-associated-retinal-lymphoma-a-1agAHbXFyG
Publisher
American Medical Association
Copyright
Copyright © 1994 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1994.01090190102028
Publisher site
See Article on Publisher Site

Abstract

Abstract Human T-cell lymphotropic virus type I has been associated with a wide range of ocular conditions, including neoplastic, infectious, and inflammatory lesions. We studied a patient infected with human T-cell lymphotropic virus type I who presented with deep retinal and subretinal infiltrates but without cells in the vitreous. The differential diagnosis included intraocular lymphoma and fungus infection. A chorioretinal biopsy specimen obtained for tissue diagnosis disclosed large atypical mononuclear cells located primarily at the level of the retinal pigment epithelium but focally involving overlying retina. Electron microscopy of this infiltrate showed features consistent with adult T-cell lymphoma/leukemia. Infection by human T-cell lymphotropic virus type I was verified by polymerase chain reaction studies conducted on peripheral-blood mononuclear cells. This case emphasizes the occurrence of intraocular lesions in adult T-cell lymphoma/leukemia that clinically show some features similar to those of the usual ocular lymphoma (reticulum cell sarcoma); diagnosis can be established by chorioretinal biopsy, thereby allowing appropriate therapy. References 1. Blattner WA. Epidemiology of HTLV-I and associated diseases . In: Blattner WA, ed. Human Retrovirology: HTLV . New York, NY: Raven Press; 1990:251-265. 2. Yoshida M, Seiki M, Yamaguchi K, Takatsuki K. Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease . Proc Natl Acad Sci U S A . 1984;81:2534-2537.Crossref 3. Osame M, Usuku K, Izumo S, et al. HTLV1 associated myelopathy, a new clinical entity . Lancet . 1986;1:1031-1032.Crossref 4. Lauer SA, Fischer J, Jones J, Gartner S, Dutcher J, Hoxie JA. Orbital T-cell lymphoma in human T-cell leukemia virus-I infection . Ophthalmology . 1988;95:110-115.Crossref 5. Hayasaka S, Takatori Y, Noda S, Setogawa T, Hayashi H. Retinal vasculitis in a mother and her son with human T-lymphotropic virus type 1 associated myelopathy . Br J Ophthalmol . 1991;75:566-567.Crossref 6. Ohba N, Matsumoto M, Sameshima M, et al. Ocular manifestations in patients infected with human T-lymphotropic virus type I . Jpn J Ophthalmol . 1989;33:1-12. 7. Mochizuki M, Watanabe T, Yamaguchi K, et al. Uveitis associated with human T-cell lymphotropic virus type I . Am J Ophthalmol . 1992;114:123-129. 8. Meyer RD, Moudgil T, Detels R, Phair JY, Hirsch MS, Ho DD. Seroprevalence of human T cell leukemia viruses in selected populations of homosexual men . J Infect Dis . 1990;162:1370-1372.Crossref 9. Gill PS, Masood R, Cai J, et al. Novel (antiviral) therapy for adult T-cell leukemia secondary to HTLV-I infection . Blood . 1992;80( (suppl 1) ):74a. Abstract. 10. Uchiyama T, Yodoi J, Sagawa K, et al. Adult T-cell leukemia: clinical and hematologic features of 16 cases . Blood . 1977;50:481-492. 11. Inomata H, Kohno T. A case of adult T-cell leukemia (ATL) with ocular involvement. Read before the International Uveitis Study Group Meeting; Pasadena, Calif; October 17, 1991. 12. Lewis H, Schachat AP. Non-Hodgkin's ('reticulum cell') lymphoma . In: Ryan SJ, ed. Retina . St Louis, Mo: CV Mosby Co; 1989;1:795-804. 13. Char DH, Margolis L, Newman AB. Ocular reticulum cell sarcoma . Am J Ophthalmol . 1981;91:480-483. 14. Shields JA, Shields CL. Intraocular Tumors: A Text and Atlas . Philadelphia, Pa: WB Saunders Co; 1992:498-504. 15. Freeman LN, Schachat AP, Knox DL, Michels RG, Green WR. Clinical features, laboratory investigations, and survival in ocular reticulum cell sarcoma . Ophthalmology . 1987;94:1631-1639.Crossref 16. Gass JDM, Sever RJ, Grizzard WS, et al. Multifocal pigment epithelial detachments by reticulum cell sarcoma: a characteristic funduscopic picture . Retina . 1984;4:135-143.Crossref 17. Green WR. Systemic diseases with retinal involvement . In: Spencer WH, ed. Ophthalmic Pathology: An Atlas and Textbook , 3rd ed. Philadelphia, Pa: WB Saunders Co; 1985:1064-1071, 1588-1591, 1656-1673. 18. Kikuchi M, Mitsui T, Takeshita M, et al. Virus associated adult T-cell leukemia (ATL) in Japan: clinical, histological and immunological studies . Hematol Oncol . 1986;4:67-81.Crossref 19. Jones SE, Fuks Z, Bull M, et al. Non-Hodgkin's lymphomas, IV: clinicopathologic correlation in 405 cases . Cancer . 1973;31:806-823.Crossref 20. Portlock CS. The non-Hodgkin's lymphomas . In: Wyngaarden JB, Smith LH, eds. Cecil Textbook of Medicine . Philadelphia, Pa: WB Saunders Co; 1988:1009-1013. 21. Kaplan HJ, Meredith TA, Aaberg TM, Keller RH. Reclassification of intraocular reticulum cell sarcoma (histiocytic lymphoma): immunologic characterization of vitreous cells . Arch Ophthalmol . 1980;98:707-710.Crossref 22. Kirmani MH, Thomas EL, Rao NA, Laborde RP. Intraocular reticulum cell sarcoma: diagnosis by choroidal biopsy . Br J Ophthalmol . 1987;71:748-752.Crossref 23. Parver LM, Font RL. Malignant lymphoma of the retina and brain: initial diagnosis by cytologic examination of vitreous aspirate . Arch Ophthalmol . 1979;97:1505-1507.Crossref 24. Engel HM, Green WR, Michels RG, Rice TA, Erozan YS. Diagnostic vitrectomy . Retina . 1981;1:121-149.Crossref 25. Yamaguchi K, Nishimura Y, Kawano F, et al. A proposal for smoldering adult T-cell leukemia: diversity in clinical pictures of adult T-cell leukemia . Jpn J Clin Oncol . 1983;13:189-200. 26. Yodoi J, Uchiyama T. Diseases associated with HTLV-I: virus, IL-2 receptor dysregulation and redox regulation . Immunol Today . 1992;13:405-410.Crossref 27. Char DH, Ljung BM, Miller T, Phillips T. Primary intraocular lymphoma (ocular reticulum cell sarcoma) diagnosis and management . Ophthalmology . 1988;95:625-630.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Jul 1, 1994

References