Abstract The present study was undertaken to investigate the possible potentiating effect of human placental lactogen (HPL) on human growth hormone (HGH). Five preadolescent hypopituitary patients, aged 6 to 12 years received, at random, three different four month courses of therapy consisting of 1 unit of HGH, 2 units of HGH, and a combination of 1 unit of HGH and 400 mg of HPL, every other day. Linear growth was comparable on the three treatment schedules suggesting absence of growth potentiation but the diabetogenic effect of HGH appeared enhanced by HPL. References 1. Josimovich JB, MacLaren JA: Presence in the human placenta and term serum of a highly lactogenic substance immunologically related to pituitary growth hormone . Endocrinology 71:209-220, 1962.Crossref 2. Grumbach MM, Kaplan SL, Sciarra JJ, et al: Chorionic growth hormone-prolactin (CGP): Secretion, disposition, biologic activity in man, and postulated function as the "growth hormone" of the second half of pregnancy . Ann NY Acad Sci 148:501-531, 1968.Crossref 3. Catt KJ, Moffat B, Niall HD: Human growth hormone and placental lactogen: Structural similarity . Science 157:321, 1967.Crossref 4. Youlton R, Kaplan SL, Grumbach MM: Growth and growth hormone: IV. Limitations of the growth hormone response to insulin and arginine and of the immunoreactive insulin response to arginine in the assessment of growth hormone deficiency in children . Pediatrics 43:989-1004, 1969. 5. Murakawa S, Raben MS: Effect of growth hormone and placental lactogen on DNA synthesis in rat costal cartilage and adipose tissue . Endocrinology 83:645-650, 1968.Crossref 6. Beas F, Salinas A, Pak N: Action of "chorionic growth hormone-prolactin" on growth and carcass composition of hypophysectionized rat . Proc Soc Exp Biol Med 131:1171-1175, 1969. 7. Schultz RB, Blizzard RM: A comparison of human placental lactogen (HPL) and human growth hormone (HGH) in hypopituitary patients . J Clin Endocr 26:921-924, 1966.Crossref 8. Florini JR, Tonelli G, Bruer CB, et al: Characterization and biological effects of purified placental protein (human) . Endocrinology 79:692-708, 1966.Crossref 9. Josimovich JB: Potentiation of somatotrophic and diabetogenic effects of growth hormone by human placental lactogen (HPL) . Endocrinology 78:707-714, 1966.Crossref 10. O'Sullivan JB: Oral glucose tolerance tests , in Hamwi GJ, Danowski TS (eds): Diabetes Mellitus: Diagnosis and Treatment . New York, American Diabetes Association Inc, 1967, vol 2, p 47. 11. Herbert V, Lau KS, Gottlieb CW, et al: Coated charcoal immunoassay of insulin . J Clin Endocr 25:1375-1384, 1965.Crossref 12. Drash AL, Chiumello G, Hengstenberg F: Studies in diabetes mellitus: Approaches to earlier diagnosis and therapy , in Heald F, Hung W (eds): Adolescent Endocrinology . New York, Appleton Century Crofts, 1970, p 51. 13. Cornblath M, Schwartz R: Disorders of Carbohydrate Metabolism in Infancy . Philadelphia, WB Saunders, 1966. 14. Aceto T Jr, Hayles AB, Parker ML, et al: Effects of human growth hormone on 79 hypopituitary children, abstracted . Pediat Res 4:459-460, 1970.Crossref 15. Raiti S, Blizzard RM: Human growth hormone: Current knowledge regarding its role in normal and abnormal metabolic states . Advances Pediat 17:99, 1970. 16. Luft R, Cerasi E: Effect of human growth hormone on insulin production in panhypopituitarism . Lancet 2:124-126, 1964.Crossref 17. Daughaday WH, Kipnis DM: The growth-promoting and anti-insulin actions of somatotropin . Recent Progr Hormone Res 22:49-99, 1966.
American Journal of Diseases of Children – American Medical Association
Published: May 1, 1972