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References (10)
-
M. Morris (1936)
THE RELATION BETWEEN ANTIANAPHYLAXIS AND ANTIBODY BALANCE : II. THE EFFECT OF SPECIFIC DESENSITIZATION UPON RESISTANCE TO INFECTION AND UPON ANTIBODY BALANCE.Journal of Experimental Medicine, 64
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V. Lippard, W. Schmidt (1937)
HUMAN PASSIVE TRANSFER ANTIBODY: I. TITRATION BY NEUTRALIZATIONJAMA Pediatrics, 54
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R. Cooke, W. Spain (1929)
Studies in Hypersensitiveness XXXVI. A Comparative Study of Antibodies Occurring in Anaphylaxis, Serum Disease and the Naturally Sensitive ManJournal of Immunology, 17
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W. Manwaring, Y. Kusama (1917)
Analysis of the Anaphylactic and Immune Reactions by Means of the Isolated Guinea-Pig LungsThe Journal of Immunology
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W. Longcope, F. Rackemann (1918)
THE RELATION OF CIRCULATING ANTIBODIES TO SERUM DISEASEThe Journal of Experimental Medicine, 27
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W. Schmidt, V. Lippard (1938)
HUMAN PASSIVE TRANSFER ANTIBODY: III. SERIAL TITRATIONS ON TREATED AND UNTREATED PATIENTS WITH HAY FEVERJAMA Pediatrics, 56
-
M. Morris (1936)
THE RELATION BETWEEN ANTIANAPHYLAXIS AND ANTIBODY BALANCE : I. THE ROLE OF EXCESS OF CIRCULATING ANTIBODY IN HYPERSENSITIVENESS.Journal of Experimental Medicine, 64
-
J. Sugg, Lurline Richardson, J. Neill (1931)
Hypersensitiveness to Diphtheria Bacterial Products: Inhibition of the Anaphylaxis of Antitoxic Immune (Actively Sensitized) Guinea PigsJournal of Immunology, 20
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W. Schmidt, V. Lippard (1937)
HUMAN PASSIVE TRANSFER ANTIBODY: II. NEUTRALIZATION OF ANTIGENJAMA Pediatrics, 54
-
R. Weil (1913)
The Nature of Anaphylaxis, and the Relations between Anaphylaxis and Immunity.The Journal of medical research, 27 4
- Publisher
- American Medical Association
- Copyright
- Copyright © 1938 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
- ISSN
- 0096-8994
- eISSN
- 1538-3628
- DOI
- 10.1001/archpedi.1938.01980160077009
- Publisher site
- See Article on Publisher Site
Abstract
Weil,1 Coca2 and von Fenyvessy and Freund3 have shown that the anaphylactic state is still demonstrable after anaphylactic antibodies are removed from the blood. Since hypersensitiveness can be transferred by antibodies, they must be associated with the anaphylactic state, but only after they reach the tissues. The assumption that circulating antibodies protect sensitized tissues from anaphylaxis is paradoxic to the evidence that they induce sensitization. In a recent communication4 we presented suggestive evidence of protection by human passive transfer antibody. The blood serums of a group of patients with hay fever were titrated by a technic which depends on neutralization of antibody by antigen. It was observed that the antibody titer increased after injection of pollen extracts in 16 of 18 patients and that relief from clinical symptoms of hay fever was associated with a rise in titer. Two patients who showed no rise in titer
Journal
American journal of diseases of children – American Medical Association
Published: Oct 1, 1938