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Human Papillomavirus-16 DNA in a Cutaneous Invasive Cancer

Human Papillomavirus-16 DNA in a Cutaneous Invasive Cancer Abstract • A middle-aged man with a 20-year history of a warty lesion on his finger was diagnosed histologically as having an invasive carcinoma at that location. Molecular analysis of the lesion showed that human papillomavirus (HPV) DNA was present in this tumor. Under stringent hybridization conditions, only HPV-16 DNA, which is commonly associated with genital neoplasia or cutaneous bowenoid lesions, was detected. Two-dimensional gel electrophoresis revealed that various sections of the tumor contained mostly episomal viral DNA; but in one case, low levels of integrated HPV-16 DNA were detected as well. (Arch Dermatol 1989;125:666-669) References 1. Ostrow R, Faras A: The molecular biology of human papillomaviruses and the pathogenesis of genital papillomaviruses and neoplasias . Cancer Metastasis Rev 1987;6:383-395.Crossref 2. Ostrow R, Bender M, Niimura M, et al: Human papillomavirus DNA in cutaneous primary and metastasized squamous cell carcinomas from patients with epidermodysplasia verruciformis . Proc Natl Acad Sci USA 1982;79:1634-1638.Crossref 3. Boshart M, Gissmann L, Ikenberg H, et al: A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer . EMBO J 1984;3:1151-1157. 4. Durst M, Kleinheinz A, Hotz M, et al: The physical state of human papillomavirus type 16 DNA in benign and malignant genital tumors . J Gen Virol 1985;66:1515-1522.Crossref 5. Matsukura T, Kanda T, Furuno A, et al: Cloning of monomeric human papillomavirus type 16 DNA integrated with cell DNA from a cervical carcinoma . J Virol 1986;58:979-982. 6. Ostrow R, Manias D, Mitchell A, et al: Epidermodysplasia verruciformis: A case associated with primary lymphatic dysplasia, depressed cell-mediated immunity, and Bowen's disease containing human papillomavirus 16 DNA . Arch Dermatol 1987; 123:1511-1516.Crossref 7. Breneman D, Lucky A, Ostrow R, et al: Bowenoid papulosis of the genitalia associated with human papillomavirus type 16 in an infant with atopic dermatitis . Pediatr Dermatol 1985;4:297-301.Crossref 8. Stone M, Noonan C, Tschen J, et al: Bowen's disease of the feet: Presence of human papillomavirus 16 DNA in tumor tissue . Arch Dermatol 1987;123:1517-1520.Crossref 9. Ostrow R, Manias D, Fong W, et al: A survey of human cancers for human papillomavirus DNA by filter hybridization . Cancer 1987;59:429-434.Crossref 10. Loning T, Ikenberg M, Becker J, et al: Analysis of oral papillomavirus, leukoplakias and invasive carcinomas for human papillomavirus type related DNA . J Invest Dermatol 1985;84:417-420.Crossref 11. Okagaki T, Twiggs L, Zachow K, et al: Identification of human papillomavirus DNA in cervical and vaginal intraepithelial neoplasia with molecularly cloned virus-specific DNA probes . Int J Gynecol Pathol 1983;2:153-159.Crossref 12. Southern E: Detection of specific sequences among DNA fragments separated by gel electrophoresis . J Mol Biol 1975; 98:503-517.Crossref 13. Wettstein F, Stevens J: Variable-sized free episomes of Shope papilloma virus DNA are present in all non-virus-producing neoplasms and integrated episomes are detected in some . Proc Natl Acad Sci USA 1982;79:790-794.Crossref 14. Manias D, Ostrow R, McGlennen R, et al: Human papillomavirus type 11 DNA is integrated in primary and metastatic tumors from a renal transplant recipient . Cancer Res , in press. 15. Rando R, Sedlacek T, Hunt J, et al: Verrucous carcinoma of the vulva associated with an unusual type 6 human papillomavirus . Obstet Gynecol 1986;67( (suppl) ):70-75.Crossref 16. Rando R, Groff D, Chirikjian J, et al: Isolation and characterization of a novel human papillomavirus type 6 DNA from an invasive vulvar carcinoma . J Virol 1986;57:353-356. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1989 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1989.01670170080014
Publisher site
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Abstract

Abstract • A middle-aged man with a 20-year history of a warty lesion on his finger was diagnosed histologically as having an invasive carcinoma at that location. Molecular analysis of the lesion showed that human papillomavirus (HPV) DNA was present in this tumor. Under stringent hybridization conditions, only HPV-16 DNA, which is commonly associated with genital neoplasia or cutaneous bowenoid lesions, was detected. Two-dimensional gel electrophoresis revealed that various sections of the tumor contained mostly episomal viral DNA; but in one case, low levels of integrated HPV-16 DNA were detected as well. (Arch Dermatol 1989;125:666-669) References 1. Ostrow R, Faras A: The molecular biology of human papillomaviruses and the pathogenesis of genital papillomaviruses and neoplasias . Cancer Metastasis Rev 1987;6:383-395.Crossref 2. Ostrow R, Bender M, Niimura M, et al: Human papillomavirus DNA in cutaneous primary and metastasized squamous cell carcinomas from patients with epidermodysplasia verruciformis . Proc Natl Acad Sci USA 1982;79:1634-1638.Crossref 3. Boshart M, Gissmann L, Ikenberg H, et al: A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer . EMBO J 1984;3:1151-1157. 4. Durst M, Kleinheinz A, Hotz M, et al: The physical state of human papillomavirus type 16 DNA in benign and malignant genital tumors . J Gen Virol 1985;66:1515-1522.Crossref 5. Matsukura T, Kanda T, Furuno A, et al: Cloning of monomeric human papillomavirus type 16 DNA integrated with cell DNA from a cervical carcinoma . J Virol 1986;58:979-982. 6. Ostrow R, Manias D, Mitchell A, et al: Epidermodysplasia verruciformis: A case associated with primary lymphatic dysplasia, depressed cell-mediated immunity, and Bowen's disease containing human papillomavirus 16 DNA . Arch Dermatol 1987; 123:1511-1516.Crossref 7. Breneman D, Lucky A, Ostrow R, et al: Bowenoid papulosis of the genitalia associated with human papillomavirus type 16 in an infant with atopic dermatitis . Pediatr Dermatol 1985;4:297-301.Crossref 8. Stone M, Noonan C, Tschen J, et al: Bowen's disease of the feet: Presence of human papillomavirus 16 DNA in tumor tissue . Arch Dermatol 1987;123:1517-1520.Crossref 9. Ostrow R, Manias D, Fong W, et al: A survey of human cancers for human papillomavirus DNA by filter hybridization . Cancer 1987;59:429-434.Crossref 10. Loning T, Ikenberg M, Becker J, et al: Analysis of oral papillomavirus, leukoplakias and invasive carcinomas for human papillomavirus type related DNA . J Invest Dermatol 1985;84:417-420.Crossref 11. Okagaki T, Twiggs L, Zachow K, et al: Identification of human papillomavirus DNA in cervical and vaginal intraepithelial neoplasia with molecularly cloned virus-specific DNA probes . Int J Gynecol Pathol 1983;2:153-159.Crossref 12. Southern E: Detection of specific sequences among DNA fragments separated by gel electrophoresis . J Mol Biol 1975; 98:503-517.Crossref 13. Wettstein F, Stevens J: Variable-sized free episomes of Shope papilloma virus DNA are present in all non-virus-producing neoplasms and integrated episomes are detected in some . Proc Natl Acad Sci USA 1982;79:790-794.Crossref 14. Manias D, Ostrow R, McGlennen R, et al: Human papillomavirus type 11 DNA is integrated in primary and metastatic tumors from a renal transplant recipient . Cancer Res , in press. 15. Rando R, Sedlacek T, Hunt J, et al: Verrucous carcinoma of the vulva associated with an unusual type 6 human papillomavirus . Obstet Gynecol 1986;67( (suppl) ):70-75.Crossref 16. Rando R, Groff D, Chirikjian J, et al: Isolation and characterization of a novel human papillomavirus type 6 DNA from an invasive vulvar carcinoma . J Virol 1986;57:353-356.

Journal

Archives of DermatologyAmerican Medical Association

Published: May 1, 1989

References