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Human Intraocular Penetration of Sodium Oxacillin

Human Intraocular Penetration of Sodium Oxacillin Abstract Patients about to undergo routine cataract extraction were given varying doses of sodium oxacillin by intramuscular injection. The injections were administered at regular intervals during the 24 hours prior to surgery. At time of operation aqueous and venous blood were obtained and subjected to bio-assay for oxacillin content. Bio-assay was by the plate inhibition method using Sarcina lutea as test organism. Oxacillin failed to penetrate the normal human blood aqueous barrier in detectable amounts in any patient. References 1. Doyle, F.P., et al: New Penicillins Stable Towards Both Acid and Penicillinase , Nature 192:1183-1184, 1961.Crossref 2. Gooding, G.W., and Pryles, C.V.: The New Penicillins , BMO 14:139-146, 1963. 3. Rutenburg, A.M., et al: Clinical Evaluation of 5-Methyl-3-Phenyl-4-Isoxazolyl Penicillin in Staphylococcal Infections , New Eng J Med 266:755-759, 1962.Crossref 4. Burns, R.P.: Postoperative Infections in an Ophthalmologic Hospital , Amer J Ophthal 48:519-526, 1959. 5. Chalkley, T.H.F.: Sepsis and Intraocular Surgery , Amer J Ophthal 56:142-143, 1963. 6. Allen, H.F., and Mangiaracine, A.B.: Bacterial Endophthalmitis After Cataract Extraction: A Study of 22 Infections in 20,000 Operations , Arch Ophthal 72:454-462, 1964.Crossref 7. McMeel, J.W., and Wapner, J.M.: Infections and Retina Surgery: I. Bacteriologic Contamination During Scleral Buckling Surgery , Arch Ophthal 74:42-44, 1965.Crossref 8. McMeel, J.W.: Infections and Retina Surgery: II. Incidence and Significance of Positive Wound Site Cultures , Arch Ophthal 74:45-47, 1965.Crossref 9. Records, R.E.: The Human Intraocular Penetration of Methicillin , Arch Ophthal 76:720-722, 1966.Crossref 10. Furgiuele, F.P.: New Antibiotics: Their Intraocular Penetration , Amer J Ophthal 58:443-447, 1964. 11. Tanaka, Mikito: Studies on the Ophthalmic Use of Penicillin Derivatives: Report V. Stability of Methyl-Phenyl-Isoxazolyl Penicillin Solution and Its Ocular Penetration , Acta Soc Ophthal Jap 67:1756-1760, 1963. 12. Klein, J.O., et al: Oxacillin in the Treatment of Severe Staphylococcal Infections , New Eng J Med 269:1215-1225, 1963.Crossref 13. Klein, J.O.; Sabath, L.D.; and Finland, M.: Laboratory Studies on Oxacillin , Amer J Med Sci 245:399-411, 1963.Crossref 14. Rolinson, G.N.: The Significance of Protein Binding of Penicillins , Postgrad Med J 40 ( (suppl) ):20-22, 1964.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Human Intraocular Penetration of Sodium Oxacillin

Archives of Ophthalmology , Volume 77 (5) – May 1, 1967

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Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1967.00980020695026
Publisher site
See Article on Publisher Site

Abstract

Abstract Patients about to undergo routine cataract extraction were given varying doses of sodium oxacillin by intramuscular injection. The injections were administered at regular intervals during the 24 hours prior to surgery. At time of operation aqueous and venous blood were obtained and subjected to bio-assay for oxacillin content. Bio-assay was by the plate inhibition method using Sarcina lutea as test organism. Oxacillin failed to penetrate the normal human blood aqueous barrier in detectable amounts in any patient. References 1. Doyle, F.P., et al: New Penicillins Stable Towards Both Acid and Penicillinase , Nature 192:1183-1184, 1961.Crossref 2. Gooding, G.W., and Pryles, C.V.: The New Penicillins , BMO 14:139-146, 1963. 3. Rutenburg, A.M., et al: Clinical Evaluation of 5-Methyl-3-Phenyl-4-Isoxazolyl Penicillin in Staphylococcal Infections , New Eng J Med 266:755-759, 1962.Crossref 4. Burns, R.P.: Postoperative Infections in an Ophthalmologic Hospital , Amer J Ophthal 48:519-526, 1959. 5. Chalkley, T.H.F.: Sepsis and Intraocular Surgery , Amer J Ophthal 56:142-143, 1963. 6. Allen, H.F., and Mangiaracine, A.B.: Bacterial Endophthalmitis After Cataract Extraction: A Study of 22 Infections in 20,000 Operations , Arch Ophthal 72:454-462, 1964.Crossref 7. McMeel, J.W., and Wapner, J.M.: Infections and Retina Surgery: I. Bacteriologic Contamination During Scleral Buckling Surgery , Arch Ophthal 74:42-44, 1965.Crossref 8. McMeel, J.W.: Infections and Retina Surgery: II. Incidence and Significance of Positive Wound Site Cultures , Arch Ophthal 74:45-47, 1965.Crossref 9. Records, R.E.: The Human Intraocular Penetration of Methicillin , Arch Ophthal 76:720-722, 1966.Crossref 10. Furgiuele, F.P.: New Antibiotics: Their Intraocular Penetration , Amer J Ophthal 58:443-447, 1964. 11. Tanaka, Mikito: Studies on the Ophthalmic Use of Penicillin Derivatives: Report V. Stability of Methyl-Phenyl-Isoxazolyl Penicillin Solution and Its Ocular Penetration , Acta Soc Ophthal Jap 67:1756-1760, 1963. 12. Klein, J.O., et al: Oxacillin in the Treatment of Severe Staphylococcal Infections , New Eng J Med 269:1215-1225, 1963.Crossref 13. Klein, J.O.; Sabath, L.D.; and Finland, M.: Laboratory Studies on Oxacillin , Amer J Med Sci 245:399-411, 1963.Crossref 14. Rolinson, G.N.: The Significance of Protein Binding of Penicillins , Postgrad Med J 40 ( (suppl) ):20-22, 1964.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: May 1, 1967

References