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Human Chorionic Gonadotropin (HCG) Treatment of Obesity

Human Chorionic Gonadotropin (HCG) Treatment of Obesity Abstract After a nine-day control period, six hospitalized obese women were placed on 500 calorie diets and were given 125 IU of human chorionic gonadotropin (HCG) intramuscularly daily for 30 days. Another five obese women received injections of diluent only and consumed identical diets for the same period. Mean weight loss in the HCG-treated group was nearly identical to that achieved by women given the placebo. Reduction of triceps skinfold thickness or circumferential body measurements of the chest, waist, hips, and thighs were not different. Patterns of change of a variety of plasma and urine substrates, electrolytes, and hormones were similar in the two groups and consistent with semistarvation and weight loss. These results indicate that HCG has no effects on chemical and hormonal parameters measured and offers no advantage over calorie restriction in promoting weight loss. (Arch Intern Med 137:151-155, 1977) References 1. Simeons ATW: Action of chorionic gonadotropin in the obese . Lancet 2:946-947, 1954.Crossref 2. Lebon P: Treatment of overweight patients with chorionic gonadotropin: Follow-up study . J Am Geriatr Soc 14:116-125, 1966. 3. Asher WL, Harper HW: Effect of human chorionic gonadotropin in weight loss, hunger, and feeling of well being . Am J Clin Nutr 26:211-218, 1973. 4. Carne S: The action of chorionic gonadotropin in the obese . Lancet 2:1282-1284, 1961.Crossref 5. Frank BW: The use of chorionic gonadotropin hormone in the treatment of obesity: A double blind study . Am J Clin Nutr 14:133-136, 1964. 6. Sohar E: A 40-day 550 calorie diet in the treatment of obese outpatients . Am J Clin Nutr 7:514-518, 1959. 7. Hill JB, Kessler G: An automated determination of glucose utilizing a glucose oxidase-peroxidase system . J Lab Clin Med 57:970-980, 1961. 8. Handel EV, Zilversmit DB: Micro-method for the direct determination of serum triglycerides . J Lab Clin Med 50:152-157, 1957. 9. Itaya K, Ui M: Calorimetric determination of free fatty acids in biological fluids . J Lipid Res 6:16-20, 1965. 10. Morgan CR, Lazarow A: Immunoassay of insulin: Two antibody system. Plasma insulin levels of normal, subdiabetic, and diabetic rats . Diabetes 12:115-126, 1963. 11. Aguilar-Parada E, Eisentraut AM, Unger RH: Pancreatic glucagon secretion in normal and diabetic subjects . Am J Med Sci 257:415-419, 1969.Crossref 12. Mejer LE, Blanchard RC: Fluorometric determination of plasma 11-hydroxycorticosteroids . Clin Chem 19:710-717, 1973. 13. Klopper A, Michie EA, Brown JB: Method of determination of urinary pregnanediol . J Endocrinol 12:209-219, 1955.Crossref 14. Farmer SW, Ramachandran J, Papkoff H: Lipolytic activity of gonadotropins and their subunits . Endocrinology 91:543-548, 1972.Crossref 15. Keys, A, Brozek J, Henschel J, et al: The Biology of Human Starvation . Minneapolis, University of Minnesota Press, 1950, vol 1. 16. Ballin JC, White PL: Fallacy and hazard: Human chorionic gonadotropin/500 calorie diet and weight reduction . JAMA 230:693-694, 1974.Crossref 17. Crout JR: Chorionic gonadotropin . Fed Register 39:42397-42403, 1974. 18. Johnson HL, Consolazio CG, Krzywich HJ: Metabolic effects of calorie restriction: Nutrient balances with 500 calorie intakes . Am J Clin Nutr 24:913-923, 1971. 19. A critique of low carbohydrate ketogenic weight reduction regimens, AMA Council on Foods and Nutrition . JAMA 224:1415-1419, 1973.Crossref 20. Mayer J: Overweight: Causes, Cost, and Control . Englewood Cliffs, NJ, Prentice Hall, 1968. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Human Chorionic Gonadotropin (HCG) Treatment of Obesity

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Publisher
American Medical Association
Copyright
Copyright © 1977 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1977.03630140007005
Publisher site
See Article on Publisher Site

Abstract

Abstract After a nine-day control period, six hospitalized obese women were placed on 500 calorie diets and were given 125 IU of human chorionic gonadotropin (HCG) intramuscularly daily for 30 days. Another five obese women received injections of diluent only and consumed identical diets for the same period. Mean weight loss in the HCG-treated group was nearly identical to that achieved by women given the placebo. Reduction of triceps skinfold thickness or circumferential body measurements of the chest, waist, hips, and thighs were not different. Patterns of change of a variety of plasma and urine substrates, electrolytes, and hormones were similar in the two groups and consistent with semistarvation and weight loss. These results indicate that HCG has no effects on chemical and hormonal parameters measured and offers no advantage over calorie restriction in promoting weight loss. (Arch Intern Med 137:151-155, 1977) References 1. Simeons ATW: Action of chorionic gonadotropin in the obese . Lancet 2:946-947, 1954.Crossref 2. Lebon P: Treatment of overweight patients with chorionic gonadotropin: Follow-up study . J Am Geriatr Soc 14:116-125, 1966. 3. Asher WL, Harper HW: Effect of human chorionic gonadotropin in weight loss, hunger, and feeling of well being . Am J Clin Nutr 26:211-218, 1973. 4. Carne S: The action of chorionic gonadotropin in the obese . Lancet 2:1282-1284, 1961.Crossref 5. Frank BW: The use of chorionic gonadotropin hormone in the treatment of obesity: A double blind study . Am J Clin Nutr 14:133-136, 1964. 6. Sohar E: A 40-day 550 calorie diet in the treatment of obese outpatients . Am J Clin Nutr 7:514-518, 1959. 7. Hill JB, Kessler G: An automated determination of glucose utilizing a glucose oxidase-peroxidase system . J Lab Clin Med 57:970-980, 1961. 8. Handel EV, Zilversmit DB: Micro-method for the direct determination of serum triglycerides . J Lab Clin Med 50:152-157, 1957. 9. Itaya K, Ui M: Calorimetric determination of free fatty acids in biological fluids . J Lipid Res 6:16-20, 1965. 10. Morgan CR, Lazarow A: Immunoassay of insulin: Two antibody system. Plasma insulin levels of normal, subdiabetic, and diabetic rats . Diabetes 12:115-126, 1963. 11. Aguilar-Parada E, Eisentraut AM, Unger RH: Pancreatic glucagon secretion in normal and diabetic subjects . Am J Med Sci 257:415-419, 1969.Crossref 12. Mejer LE, Blanchard RC: Fluorometric determination of plasma 11-hydroxycorticosteroids . Clin Chem 19:710-717, 1973. 13. Klopper A, Michie EA, Brown JB: Method of determination of urinary pregnanediol . J Endocrinol 12:209-219, 1955.Crossref 14. Farmer SW, Ramachandran J, Papkoff H: Lipolytic activity of gonadotropins and their subunits . Endocrinology 91:543-548, 1972.Crossref 15. Keys, A, Brozek J, Henschel J, et al: The Biology of Human Starvation . Minneapolis, University of Minnesota Press, 1950, vol 1. 16. Ballin JC, White PL: Fallacy and hazard: Human chorionic gonadotropin/500 calorie diet and weight reduction . JAMA 230:693-694, 1974.Crossref 17. Crout JR: Chorionic gonadotropin . Fed Register 39:42397-42403, 1974. 18. Johnson HL, Consolazio CG, Krzywich HJ: Metabolic effects of calorie restriction: Nutrient balances with 500 calorie intakes . Am J Clin Nutr 24:913-923, 1971. 19. A critique of low carbohydrate ketogenic weight reduction regimens, AMA Council on Foods and Nutrition . JAMA 224:1415-1419, 1973.Crossref 20. Mayer J: Overweight: Causes, Cost, and Control . Englewood Cliffs, NJ, Prentice Hall, 1968.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Feb 1, 1977

References