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How a Natural Molecule May Protect Against Autoimmune Diseases

How a Natural Molecule May Protect Against Autoimmune Diseases News & Analysis New method Traditional method Bacteria-specific Nonspecific Lab Reports Generating Pancreatic Beta Cells tion. Although previous work has impli- Researchers at the Harvard Stem Cell Insti- cated the importance of NAD+ in EAE pa- tute have used small molecules and pro- thology, this study uncovers the role and teins to coax human pluripotent stem cells underlying mechanism of NAD+ in the im- to become insulin-secreting pancreatic beta mune response. Notably, scientists discov- cells in vitro (Pagliuca FW et al. Cell.2014; ered that NAD+ protects against EAE by al- 159[2]:428-439). tering T-cell differentiation through a novel The research team’s novel differentia- noncanonical enzymatic pathway indepen- tion protocol can generate hundreds of mil- dent from previously described classical lions of cells that express markers found in cytokine and transcription factor signaling. mature pancreatic beta cells, package insu- Given the unique properties of NAD+ in lin into secretory granules, and secrete in- altering the systemic immune response, the sulin in response to glucose challenges. findings suggest it may also benefit pa- The cells also secreted human insulin af- tients with autoimmune conditions other ter transplantation into diabetic mice, ame- than multiple sclerosis. liorating their hyperglycemia. Fasting blood A novel sorbitol-containing http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

How a Natural Molecule May Protect Against Autoimmune Diseases

JAMA , Volume 312 (21) – Dec 3, 2014

How a Natural Molecule May Protect Against Autoimmune Diseases

Abstract

News & Analysis New method Traditional method Bacteria-specific Nonspecific Lab Reports Generating Pancreatic Beta Cells tion. Although previous work has impli- Researchers at the Harvard Stem Cell Insti- cated the importance of NAD+ in EAE pa- tute have used small molecules and pro- thology, this study uncovers the role and teins to coax human pluripotent stem cells underlying mechanism of NAD+ in the im- to become insulin-secreting pancreatic beta mune response. Notably, scientists...
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Publisher
American Medical Association
Copyright
Copyright 2014 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2014.16227
Publisher site
See Article on Publisher Site

Abstract

News & Analysis New method Traditional method Bacteria-specific Nonspecific Lab Reports Generating Pancreatic Beta Cells tion. Although previous work has impli- Researchers at the Harvard Stem Cell Insti- cated the importance of NAD+ in EAE pa- tute have used small molecules and pro- thology, this study uncovers the role and teins to coax human pluripotent stem cells underlying mechanism of NAD+ in the im- to become insulin-secreting pancreatic beta mune response. Notably, scientists discov- cells in vitro (Pagliuca FW et al. Cell.2014; ered that NAD+ protects against EAE by al- 159[2]:428-439). tering T-cell differentiation through a novel The research team’s novel differentia- noncanonical enzymatic pathway indepen- tion protocol can generate hundreds of mil- dent from previously described classical lions of cells that express markers found in cytokine and transcription factor signaling. mature pancreatic beta cells, package insu- Given the unique properties of NAD+ in lin into secretory granules, and secrete in- altering the systemic immune response, the sulin in response to glucose challenges. findings suggest it may also benefit pa- The cells also secreted human insulin af- tients with autoimmune conditions other ter transplantation into diabetic mice, ame- than multiple sclerosis. liorating their hyperglycemia. Fasting blood A novel sorbitol-containing

Journal

JAMAAmerican Medical Association

Published: Dec 3, 2014

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