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Host Response to Implanted Dacron Grafts: A Comparison Between Mesh and Velour

Host Response to Implanted Dacron Grafts: A Comparison Between Mesh and Velour Abstract • Segments of open Dacron mesh grafts were subcutaneously implanted in rats and harvested for a period of up to 12 weeks after operation at serial intervals. The gross and histologic events of the host response to the external surface were compared to that of segments of low-porosity Dacron velour implanted in a similar fashion. Mature collagen, generously vascularized with new capillaries, was noted throughout the mesh within three to four weeks, while a tightly bonded inner fibrous layer had formed from the surrounding tissues. Major segments of velour floated in amorphous caseous material for up to five weeks. These pools of debris with their concomitant inflammatory response slowly resolved during a ten-week period. This prolonged healing may contribute to eventual graft closure by progressive fibrosis and extrinsic contracture. (Arch Surg 110:1469-1472, 1975) References 1. DeBakey ME, Jordan GL Jr, Abbott JP, et al: The fate of Dacron vascular grafts . Arch Surg 89:757-782, 1964. 2. Parsonnet V, Alpert J, Brief DK: Autogenous polyprophylene-supported collagen tubes for long-term arterial replacement . Surgery 70:935-939, 1971. 3. Hall KV: The arterial homograft used as "bypass" in patients with femoro-popliteal arteriosclerotic obstruction: A follow-up study . Acta Chir Scand 127:353-366, 1964. 4. Wesolowski SA, Fries CC, Henniger G, et al: Factors contributing to long-term failures in human vascular prosthetic grafts . J Cardiovasc Surg 5:544-567, 1964. 5. Kouchoukos NT, Levy JF, Balfour JF, et al: Operative therapy for femoral-popliteal arterial occlusive disease: A comparison of therapeutic methods . Circulation 35( (suppl 1) ):174-182, 1967.Crossref 6. Warren R, McCoombs HL: Morphologic studies on plastic arterial prosthesis in humans . Ann Surg 161:73-82, 1965.Crossref 7. Sparks CH: Die-grown reinforced arterial grafts: Observations on long-term animal grafts and clinical experience . Ann Surg 172:787-792, 1970.Crossref 8. Sparks CH: Silicone mandril method of femoropopliteal artery bypass . Am J Surg 124:244-249, 1972.Crossref 9. Morgan AP, Lazarus JM: Vascular access for dialysis: Techniques and results with newer methods. Am J Surg, to be published. 10. Sauvage LR, Berger K, Wood SJ, et al: An external velour surface for porous arterial prosthesis . Surgery 70:940-953, 1971. 11. Brais MP, Braunwald NS: Tissue acceptance of materials implanted within the circulatory system . Arch Surg 109:351-358, 1974.Crossref 12. Ghidoni JJ, Liotta D, Hall CW, et al: Healing of pseudointimas in velour-lined, impermeable arterial prosthesis . Am J Pathol 53:375-390, 1968. 13. Wesolowski SA, Fries CC, Karlson KE, et al: Porosity: Primary determinant of ultimate fate of synthetic vascular grafts . Surgery 50:91-96, 1961. 14. Hernández-Jaúregui P, Esperanza-Garciá C, González-Angulo A: Morphology of the connective tissue grown in response to implanted silicone rubber. A light and microscopic study . Surgery 75:631-637, 1974. 15. Florey HW, Greer SJ, Kiser J, et al: The development of the pseudointima lining fabric grafts of the aorta . Br J Exp Pathol 43:655-660, 1962. 16. Gillman T, Wright LJ: Autoradiographic evidence suggesting in vivo transformation of some blood mononuclears in repair and fibrosis . Nature 209:1086-1090, 1966.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Host Response to Implanted Dacron Grafts: A Comparison Between Mesh and Velour

Archives of Surgery , Volume 110 (12) – Dec 1, 1975

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Publisher
American Medical Association
Copyright
Copyright © 1975 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1975.01360180039008
Publisher site
See Article on Publisher Site

Abstract

Abstract • Segments of open Dacron mesh grafts were subcutaneously implanted in rats and harvested for a period of up to 12 weeks after operation at serial intervals. The gross and histologic events of the host response to the external surface were compared to that of segments of low-porosity Dacron velour implanted in a similar fashion. Mature collagen, generously vascularized with new capillaries, was noted throughout the mesh within three to four weeks, while a tightly bonded inner fibrous layer had formed from the surrounding tissues. Major segments of velour floated in amorphous caseous material for up to five weeks. These pools of debris with their concomitant inflammatory response slowly resolved during a ten-week period. This prolonged healing may contribute to eventual graft closure by progressive fibrosis and extrinsic contracture. (Arch Surg 110:1469-1472, 1975) References 1. DeBakey ME, Jordan GL Jr, Abbott JP, et al: The fate of Dacron vascular grafts . Arch Surg 89:757-782, 1964. 2. Parsonnet V, Alpert J, Brief DK: Autogenous polyprophylene-supported collagen tubes for long-term arterial replacement . Surgery 70:935-939, 1971. 3. Hall KV: The arterial homograft used as "bypass" in patients with femoro-popliteal arteriosclerotic obstruction: A follow-up study . Acta Chir Scand 127:353-366, 1964. 4. Wesolowski SA, Fries CC, Henniger G, et al: Factors contributing to long-term failures in human vascular prosthetic grafts . J Cardiovasc Surg 5:544-567, 1964. 5. Kouchoukos NT, Levy JF, Balfour JF, et al: Operative therapy for femoral-popliteal arterial occlusive disease: A comparison of therapeutic methods . Circulation 35( (suppl 1) ):174-182, 1967.Crossref 6. Warren R, McCoombs HL: Morphologic studies on plastic arterial prosthesis in humans . Ann Surg 161:73-82, 1965.Crossref 7. Sparks CH: Die-grown reinforced arterial grafts: Observations on long-term animal grafts and clinical experience . Ann Surg 172:787-792, 1970.Crossref 8. Sparks CH: Silicone mandril method of femoropopliteal artery bypass . Am J Surg 124:244-249, 1972.Crossref 9. Morgan AP, Lazarus JM: Vascular access for dialysis: Techniques and results with newer methods. Am J Surg, to be published. 10. Sauvage LR, Berger K, Wood SJ, et al: An external velour surface for porous arterial prosthesis . Surgery 70:940-953, 1971. 11. Brais MP, Braunwald NS: Tissue acceptance of materials implanted within the circulatory system . Arch Surg 109:351-358, 1974.Crossref 12. Ghidoni JJ, Liotta D, Hall CW, et al: Healing of pseudointimas in velour-lined, impermeable arterial prosthesis . Am J Pathol 53:375-390, 1968. 13. Wesolowski SA, Fries CC, Karlson KE, et al: Porosity: Primary determinant of ultimate fate of synthetic vascular grafts . Surgery 50:91-96, 1961. 14. Hernández-Jaúregui P, Esperanza-Garciá C, González-Angulo A: Morphology of the connective tissue grown in response to implanted silicone rubber. A light and microscopic study . Surgery 75:631-637, 1974. 15. Florey HW, Greer SJ, Kiser J, et al: The development of the pseudointima lining fabric grafts of the aorta . Br J Exp Pathol 43:655-660, 1962. 16. Gillman T, Wright LJ: Autoradiographic evidence suggesting in vivo transformation of some blood mononuclears in repair and fibrosis . Nature 209:1086-1090, 1966.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Dec 1, 1975

References