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Homotransplantation Of the Canine Liver: Survival and Histology With and Without Azathioprine

Homotransplantation Of the Canine Liver: Survival and Histology With and Without Azathioprine Abstract IN 1956, Goodrich and associates1 demonstrated that homotransplantation (allogeneic transplantation) of the canine liver was technically possible and that the graft functioned to some extent for as long as five days. Subsequently, there have been several studies1-11 of liver homografts in the dog and in man and it has been shown that a hepatic homograft may function for five to ten days in the untreated dog and much longer in dogs receiving azathioprine (Imuran).2,11 Several methods have been developed for implanting canine hepatic homografts in host animals. Some investigators have performed orthotopic homotransplantation3,5,6,8,9 while others have left the recipient's liver in place and attached the transplanted liver heterotopically. Heterotopic grafts have been placed in the pelvis,1,2,4,7,10,11 in the space normally occupied by the spleen,2 and in the left thoracic cavity.2 The present experiments were performed to study the technical problems involved in heterotopic References 1. Goodrich, E. O., et al: Homotransplantation of Canine Liver , Surgery 39:244-251 ( (Feb) ) 1956. 2. Absolon, K. O.: Personal communication to the author. 3. Kukral, J. C., et al: Hepatic Function After Canine Liver Transplantation , Arch Surg 85:157-165 ( (July) ) 1962.Crossref 4. Mehrez, I. O., et al: Homotransplantation of Canine Liver: New Technic , Ann Surg 159:416-423 ( (March) ) 1964.Crossref 5. Moore, F. D., et al: Experimental Whole-Organ Transplantation of Liver and Spleen , Ann Surg 152:374-387 ( (Sept) ) 1960. 6. Moore, F. D., et al: One-Stage Homotransplantation of Liver Following Total Hepatectomy in Dogs , Transplantation 6:103-106 ( (Jan) ) 1959. 7. Sicular, A., et al: Rejection of Homotransplanted Dog Liver in Absence of Hepatic Insufficiency , Proc Soc Exp Biol Med 112:760-764 ( (March) ) 1963.Crossref 8. Starzl, T. E., et al: Studies on Rejection of Transplanted Homologous Dog Liver , Surg Gynec Obstet 112:135-144 ( (Feb) ) 1961. 9. Starzl, T. E., et al: Reconstructive Problems in Canine Liver Homotransplantation With Special Reference to Postoperative Role of Hepatic Venous Flow , Surg Gynec Obstet 111:733-743 ( (Dec) ) 1960. 10. Welch, C. S.: Note on Transplantation of Whole Liver in Dogs , Transplantation 2:54-55 ( (April) ) 1955. 11. Starzl, T. E., et al: Immunosuppression After Experimental and Clinical Homotransplantation of Liver , Ann Surg 160:411-438 ( (Sept) ) 1964.Crossref 12. Thomas, W. D., and Essex, H. E.: Observations on Hepatic Venous Circulation With Special Reference to Sphincteric Mechanism , Amer J Phvsiol 158:303-310 ( (Aug) ) 1949. 13. Veith, F. J.; Luck, R. J.; and Murray, J. E.: Splenectomy in Immunosuppressive Regimens in Dog and Man , Surg Forum 15:161-163, 1964. 14. Bollman, J. L.: Animal With Eck Fistula , Physiol Rev 41:607-621 ( (July) ) 1961. 15. Child, C. G., III, et al: Liver Regeneration Following Portacaval Transposition in Dogs , Ann Surg 138:600-608 ( (Oct) ) 1953.Crossref 16. McBride, R. A., et al: Homotransplantation of Canine Liver as Orthotopic Vascularized Graft: Histologic and Functional Correlations During Residence in New Host , Amer J Path 41:501-519 ( (Nov) ) 1962. 17. Shorter, R. G., et al: Renal Homotransplantation in Dogs , J Surg Res 4:537-549 ( (Dec) ) 1964.Crossref 18. T. E. Starzl, MD; T. L. Marchioro, MD; D. T. Rowlands, Jr., MD; C. H. Kirkpatrick, MD; W. E. C. Wilson, MD; D. Rifkind, MD; and W. R. Waddell, MD, Ann Surg 160:411, 1964.Crossref 19. Physiologic requirements for auxiliary liver homotransplantation, T. L. Marchioro, MD; K. A. Porter, MD; T. C. Dickinson, MD; T. D. Faris, MD; and T. E. Starzl, MD, Surg Gynec Obstet 120 (June) 1965. In press. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Homotransplantation Of the Canine Liver: Survival and Histology With and Without Azathioprine

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Publisher
American Medical Association
Copyright
Copyright © 1965 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1965.01320100071012
Publisher site
See Article on Publisher Site

Abstract

Abstract IN 1956, Goodrich and associates1 demonstrated that homotransplantation (allogeneic transplantation) of the canine liver was technically possible and that the graft functioned to some extent for as long as five days. Subsequently, there have been several studies1-11 of liver homografts in the dog and in man and it has been shown that a hepatic homograft may function for five to ten days in the untreated dog and much longer in dogs receiving azathioprine (Imuran).2,11 Several methods have been developed for implanting canine hepatic homografts in host animals. Some investigators have performed orthotopic homotransplantation3,5,6,8,9 while others have left the recipient's liver in place and attached the transplanted liver heterotopically. Heterotopic grafts have been placed in the pelvis,1,2,4,7,10,11 in the space normally occupied by the spleen,2 and in the left thoracic cavity.2 The present experiments were performed to study the technical problems involved in heterotopic References 1. Goodrich, E. O., et al: Homotransplantation of Canine Liver , Surgery 39:244-251 ( (Feb) ) 1956. 2. Absolon, K. O.: Personal communication to the author. 3. Kukral, J. C., et al: Hepatic Function After Canine Liver Transplantation , Arch Surg 85:157-165 ( (July) ) 1962.Crossref 4. Mehrez, I. O., et al: Homotransplantation of Canine Liver: New Technic , Ann Surg 159:416-423 ( (March) ) 1964.Crossref 5. Moore, F. D., et al: Experimental Whole-Organ Transplantation of Liver and Spleen , Ann Surg 152:374-387 ( (Sept) ) 1960. 6. Moore, F. D., et al: One-Stage Homotransplantation of Liver Following Total Hepatectomy in Dogs , Transplantation 6:103-106 ( (Jan) ) 1959. 7. Sicular, A., et al: Rejection of Homotransplanted Dog Liver in Absence of Hepatic Insufficiency , Proc Soc Exp Biol Med 112:760-764 ( (March) ) 1963.Crossref 8. Starzl, T. E., et al: Studies on Rejection of Transplanted Homologous Dog Liver , Surg Gynec Obstet 112:135-144 ( (Feb) ) 1961. 9. Starzl, T. E., et al: Reconstructive Problems in Canine Liver Homotransplantation With Special Reference to Postoperative Role of Hepatic Venous Flow , Surg Gynec Obstet 111:733-743 ( (Dec) ) 1960. 10. Welch, C. S.: Note on Transplantation of Whole Liver in Dogs , Transplantation 2:54-55 ( (April) ) 1955. 11. Starzl, T. E., et al: Immunosuppression After Experimental and Clinical Homotransplantation of Liver , Ann Surg 160:411-438 ( (Sept) ) 1964.Crossref 12. Thomas, W. D., and Essex, H. E.: Observations on Hepatic Venous Circulation With Special Reference to Sphincteric Mechanism , Amer J Phvsiol 158:303-310 ( (Aug) ) 1949. 13. Veith, F. J.; Luck, R. J.; and Murray, J. E.: Splenectomy in Immunosuppressive Regimens in Dog and Man , Surg Forum 15:161-163, 1964. 14. Bollman, J. L.: Animal With Eck Fistula , Physiol Rev 41:607-621 ( (July) ) 1961. 15. Child, C. G., III, et al: Liver Regeneration Following Portacaval Transposition in Dogs , Ann Surg 138:600-608 ( (Oct) ) 1953.Crossref 16. McBride, R. A., et al: Homotransplantation of Canine Liver as Orthotopic Vascularized Graft: Histologic and Functional Correlations During Residence in New Host , Amer J Path 41:501-519 ( (Nov) ) 1962. 17. Shorter, R. G., et al: Renal Homotransplantation in Dogs , J Surg Res 4:537-549 ( (Dec) ) 1964.Crossref 18. T. E. Starzl, MD; T. L. Marchioro, MD; D. T. Rowlands, Jr., MD; C. H. Kirkpatrick, MD; W. E. C. Wilson, MD; D. Rifkind, MD; and W. R. Waddell, MD, Ann Surg 160:411, 1964.Crossref 19. Physiologic requirements for auxiliary liver homotransplantation, T. L. Marchioro, MD; K. A. Porter, MD; T. C. Dickinson, MD; T. D. Faris, MD; and T. E. Starzl, MD, Surg Gynec Obstet 120 (June) 1965. In press.

Journal

Archives of SurgeryAmerican Medical Association

Published: Apr 1, 1965

References