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Homograft Skin for Wound Coverage: A Study in Versatility

Homograft Skin for Wound Coverage: A Study in Versatility Abstract Closure of the open burn wound is the most important factor in the recovery of the thermally injured patient. In lieu of autograft skin, materials have been sought that would effectively cover large open wounds. Such a substance would of necessity provide the following: (1) control of bacterial growth, (2) a means to prepare and preserve the wounds for definitive closure, and (3) effective vapor and exudate barrier. Many artificial substances have been tried, and some have been successful in accomplishing adherence by means of tissue ingrowth. Unfortunately, one cannot equate adherence with protection, and invasive infection usually supervenes. Homograft skin, however, satisfies all the requirements in a uniquely effective manner. In 1881, Girdner reported the removal of skin from a suicide victim for use on the wounds of a patient struck by lightning.1 That same year, Schede utilized skin from fresh amputation specimens as well as from cadavers. References 1. Girdner, J.H.: Skin Grafting With Grafts Taken From the Dead Subject , Med Record of NY 20:119, 1881. 2. Rogers, B.O.: Guide and Bibliography for Research Into the Skin Homograft Problem , Plast Reconstr Surg 7:169-201 ( (March) ) 1951.Crossref 3. Artz, C.P., et al: Postmortem Skin Homografts in the Treatment of Extensive Bums , Arch Surg 71:682-687 ( (Nov) ) 1955.Crossref 4. Brown, J.B.; Fryer, M.P.; and Zaydon, T.J.: Establishing a Skin Bank: Use and Various Methods of Preservation of Postmortem Homografts , Plast Reconstr Surg 16:337-351 ( (Nov) ) 1955.Crossref 5. Dogo, G.: Survival and Utilization of Cadaver Skin , Plast Reconstr Surg 10:10-13 ( (July) ) 1952. 6. Haynes, B.W., Jr.: Skin Homografts: A Life-saving Measure in Severely Burned Children , J Trauma 3:217-224 ( (May) ) 1963.Crossref 7. MacMillan, B.G.: Homograft Skin: A Valuable Adjunct to the Treatment of Thermal Burns , J Trauma 2:130-141 ( (March) ) 1962.Crossref 8. Zaroff, LI., et al: Multiple Uses of Viable Cutaneous Homografts in the Burned Patient , Surgery 59:368-372 ( (March) ) 1966. 9. Miller, T.A., et al: Early Homografting of Second Degree Burns , Plast Reconstr Surg 40:117-125 ( (Aug) ) 1967.Crossref 10. Morris, P.J.; Bondoc, C.; and Burke, J.F.: The Use of Frequently Changed Skin Allografts to Promote Healing in the Nonhealing Infected Ulcer , Surgery 60:13-19 ( (July) ) 1966. 11. Burke, J.F., and Bondoc, C.C.: A Method of Secondary Closure of Heavily Contaminated Wounds Providing "Physiologic Primary Closure," J Trauma 8:228-237 ( (March) ) 1968.Crossref 12. Shuck, J.M., and Moncrief, J.A.: The Management of Burns, Curr Prob Surg, to be published. 13. Shuck, J.M., et al: Clinical Operation, Burn Center , section 1, US Army Surgical Research Unit Annual Report, Brooke Army Medical Center, Fort Sam Houston, Tex, (June 30) , 1968. 14. O'Neill, J.A., Jr., et al: Suppurative Thrombophlebitis: A Lethal Complication of Intravenous Therapy , J Trauma 8:256-267 ( (March) ) 1968.Crossref 15. Eade, G.G.: The Relationship Between Granulation Tissue, Bacteria, and Skin Grafts in Burned Patients , Plast Reconstr Surg 22:42-55 ( (July) ) 1958.Crossref 16. Dowling, J.A.; Kirksey, T.D.; and Moncrief, J.A.: Preservation of the Burned Thumb , J Trauma 8:3-8 ( (Jan) ) 1968.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Homograft Skin for Wound Coverage: A Study in Versatility

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Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1969.01340100104014
Publisher site
See Article on Publisher Site

Abstract

Abstract Closure of the open burn wound is the most important factor in the recovery of the thermally injured patient. In lieu of autograft skin, materials have been sought that would effectively cover large open wounds. Such a substance would of necessity provide the following: (1) control of bacterial growth, (2) a means to prepare and preserve the wounds for definitive closure, and (3) effective vapor and exudate barrier. Many artificial substances have been tried, and some have been successful in accomplishing adherence by means of tissue ingrowth. Unfortunately, one cannot equate adherence with protection, and invasive infection usually supervenes. Homograft skin, however, satisfies all the requirements in a uniquely effective manner. In 1881, Girdner reported the removal of skin from a suicide victim for use on the wounds of a patient struck by lightning.1 That same year, Schede utilized skin from fresh amputation specimens as well as from cadavers. References 1. Girdner, J.H.: Skin Grafting With Grafts Taken From the Dead Subject , Med Record of NY 20:119, 1881. 2. Rogers, B.O.: Guide and Bibliography for Research Into the Skin Homograft Problem , Plast Reconstr Surg 7:169-201 ( (March) ) 1951.Crossref 3. Artz, C.P., et al: Postmortem Skin Homografts in the Treatment of Extensive Bums , Arch Surg 71:682-687 ( (Nov) ) 1955.Crossref 4. Brown, J.B.; Fryer, M.P.; and Zaydon, T.J.: Establishing a Skin Bank: Use and Various Methods of Preservation of Postmortem Homografts , Plast Reconstr Surg 16:337-351 ( (Nov) ) 1955.Crossref 5. Dogo, G.: Survival and Utilization of Cadaver Skin , Plast Reconstr Surg 10:10-13 ( (July) ) 1952. 6. Haynes, B.W., Jr.: Skin Homografts: A Life-saving Measure in Severely Burned Children , J Trauma 3:217-224 ( (May) ) 1963.Crossref 7. MacMillan, B.G.: Homograft Skin: A Valuable Adjunct to the Treatment of Thermal Burns , J Trauma 2:130-141 ( (March) ) 1962.Crossref 8. Zaroff, LI., et al: Multiple Uses of Viable Cutaneous Homografts in the Burned Patient , Surgery 59:368-372 ( (March) ) 1966. 9. Miller, T.A., et al: Early Homografting of Second Degree Burns , Plast Reconstr Surg 40:117-125 ( (Aug) ) 1967.Crossref 10. Morris, P.J.; Bondoc, C.; and Burke, J.F.: The Use of Frequently Changed Skin Allografts to Promote Healing in the Nonhealing Infected Ulcer , Surgery 60:13-19 ( (July) ) 1966. 11. Burke, J.F., and Bondoc, C.C.: A Method of Secondary Closure of Heavily Contaminated Wounds Providing "Physiologic Primary Closure," J Trauma 8:228-237 ( (March) ) 1968.Crossref 12. Shuck, J.M., and Moncrief, J.A.: The Management of Burns, Curr Prob Surg, to be published. 13. Shuck, J.M., et al: Clinical Operation, Burn Center , section 1, US Army Surgical Research Unit Annual Report, Brooke Army Medical Center, Fort Sam Houston, Tex, (June 30) , 1968. 14. O'Neill, J.A., Jr., et al: Suppurative Thrombophlebitis: A Lethal Complication of Intravenous Therapy , J Trauma 8:256-267 ( (March) ) 1968.Crossref 15. Eade, G.G.: The Relationship Between Granulation Tissue, Bacteria, and Skin Grafts in Burned Patients , Plast Reconstr Surg 22:42-55 ( (July) ) 1958.Crossref 16. Dowling, J.A.; Kirksey, T.D.; and Moncrief, J.A.: Preservation of the Burned Thumb , J Trauma 8:3-8 ( (Jan) ) 1968.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Apr 1, 1969

References