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Homeostasis vs Allostasis

Homeostasis vs Allostasis Clinical Review & Education Neuroscience and Psychiatry Implications for Brain Function and Mental Disorders Peter Sterling, PhD Most drugs that alter mental function, whether for recreational then corrects them, allostasis uses prior knowledge, both innate and purposes or to treat mental disorders, affect synaptic transmis- learned, to prevent errors and minimize them. sion.Somedrugsreshapetheactionpotential,alteringreleaseofneu- Parameter values vary widely above and below the mean, but rotransmitter; others antagonize or enhance the effect of a neu- not because they are “inappropriate.” Rather, it is because the brain rotransmitteronitssynapticreceptorprotein.Stillotherdrugsinhibit predicts changes in need and continuously retunes parameters to reuptake of the neurotransmitter from the extracellular space, thus keep them exactly appropriate. Reconsider glucose vs insulin: when prolonging its action at the synapse. This leads naturally to the idea you are seated at a computer, the brain predicts modest need for that disorders of thought, attention, and mood are fundamentally glucose uptake by muscle and a modest need for insulin, which al- disorders of the synapse. Moreover, it presents a rationale for treat- lows that uptake. So the brain commands the neuroendocrine and ing mental disorders by pharmacotherapy of the synapse. autonomic systems to set the levels low. When the brain decides that The http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Psychiatry American Medical Association

Homeostasis vs Allostasis

Sterling, Peter
JAMA Psychiatry , Volume 71 (10) – Oct 1, 2014
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Publisher
American Medical Association
Copyright
Copyright 2014 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-622X
eISSN
2168-6238
DOI
10.1001/jamapsychiatry.2014.1043
pmid
25103620
Publisher site
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Abstract

Clinical Review & Education Neuroscience and Psychiatry Implications for Brain Function and Mental Disorders Peter Sterling, PhD Most drugs that alter mental function, whether for recreational then corrects them, allostasis uses prior knowledge, both innate and purposes or to treat mental disorders, affect synaptic transmis- learned, to prevent errors and minimize them. sion.Somedrugsreshapetheactionpotential,alteringreleaseofneu- Parameter values vary widely above and below the mean, but rotransmitter; others antagonize or enhance the effect of a neu- not because they are “inappropriate.” Rather, it is because the brain rotransmitteronitssynapticreceptorprotein.Stillotherdrugsinhibit predicts changes in need and continuously retunes parameters to reuptake of the neurotransmitter from the extracellular space, thus keep them exactly appropriate. Reconsider glucose vs insulin: when prolonging its action at the synapse. This leads naturally to the idea you are seated at a computer, the brain predicts modest need for that disorders of thought, attention, and mood are fundamentally glucose uptake by muscle and a modest need for insulin, which al- disorders of the synapse. Moreover, it presents a rationale for treat- lows that uptake. So the brain commands the neuroendocrine and ing mental disorders by pharmacotherapy of the synapse. autonomic systems to set the levels low. When the brain decides that The

Journal

JAMA Psychiatry – American Medical Association

Published: Oct 1, 2014

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