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HLA Typing in Amyotrophic Lateral Sclerosis

HLA Typing in Amyotrophic Lateral Sclerosis Abstract To the Editor.— Several reports, most recently by Bartfeld et al,1 indicate possible HLA system involvement in amyotrophic lateral sclerosis (ALS). For example, Bartfeld and co-workers1 found a trend toward increased frequency of HLA-Bw35, in agreement with Kott et al.2 What has not been emphasized is that statistical trends are not important when other studies find different trends. For example, Antel et al3 found increases of HLA-A3 in rapidly progressive ALS and HLA-Bw12 in ALS with slower courses. Kott et al2 also found a significant increase in HLA-A3; they stated that their HLA-Bw35 increase was not significant. Jokelainen et al4 found an increased incidence of HLA-Bw40 in ALS cases with slower courses. Behan and colleagues5 report References 1. Bartfeld H, Pollack MS, Cunningham-Rundles S, et al: HLA frequencies in amyotrophic lateral sclerosis . Arch Neurol 1982;39:270-271.Crossref 2. Kott E, Livni E, Zamir R, et al: Cellmediated immunity to polio and HLA antigens in amyotrophic lateral sclerosis . Neurology 1979;29:1040-1044.Crossref 3. Antel JP, Arnason BGW, Fuller TC, et al: Histocompatibility typing in amyotrophic lateral sclerosis . Arch Neurol 1976;33:423-435.Crossref 4. Jokelainen M, Tulikainen A, Lapinleimu K: Polio antibodies and HLA antigens in amyotrophic lateral sclerosis . Tissue Antigens 1977;10:259-266.Crossref 5. Behan PO, Dick HM, Durward WF: Histocompatibility antigens associated with motor neuron disease . J Neurol Sci 1977;32:213-217.Crossref 6. Pederson L, Platz P, Jersild C, et al: HLA (SD and LD) in patients with amyotrophic lateral sclerosis (ALS) . J Neurol Sci 1977;31:313-318.Crossref 7. Antel JP, Noronha ABC, Oger JJ-F, et al: Immunology of amyotrophic lateral sclerosis , in Rowland LP (ed): Human Motor Neuron Diseases . New York, Raven Press, 1982, pp 395-400. 8. Hoffman PM, Robbins DS, Nolte MJ, et al: Cellular immunity in Guamanians with amyotrophic lateral sclerosis and Parkinsonism-dementia . N Engl J Med 1978;299:680-685.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

HLA Typing in Amyotrophic Lateral Sclerosis

HLA Typing in Amyotrophic Lateral Sclerosis

Abstract

Abstract To the Editor.— Several reports, most recently by Bartfeld et al,1 indicate possible HLA system involvement in amyotrophic lateral sclerosis (ALS). For example, Bartfeld and co-workers1 found a trend toward increased frequency of HLA-Bw35, in agreement with Kott et al.2 What has not been emphasized is that statistical trends are not important when other studies find different trends. For example, Antel et al3 found increases of HLA-A3 in rapidly progressive ALS and HLA-Bw12 in...
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Publisher
American Medical Association
Copyright
Copyright © 1986 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1986.00520010007002
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— Several reports, most recently by Bartfeld et al,1 indicate possible HLA system involvement in amyotrophic lateral sclerosis (ALS). For example, Bartfeld and co-workers1 found a trend toward increased frequency of HLA-Bw35, in agreement with Kott et al.2 What has not been emphasized is that statistical trends are not important when other studies find different trends. For example, Antel et al3 found increases of HLA-A3 in rapidly progressive ALS and HLA-Bw12 in ALS with slower courses. Kott et al2 also found a significant increase in HLA-A3; they stated that their HLA-Bw35 increase was not significant. Jokelainen et al4 found an increased incidence of HLA-Bw40 in ALS cases with slower courses. Behan and colleagues5 report References 1. Bartfeld H, Pollack MS, Cunningham-Rundles S, et al: HLA frequencies in amyotrophic lateral sclerosis . Arch Neurol 1982;39:270-271.Crossref 2. Kott E, Livni E, Zamir R, et al: Cellmediated immunity to polio and HLA antigens in amyotrophic lateral sclerosis . Neurology 1979;29:1040-1044.Crossref 3. Antel JP, Arnason BGW, Fuller TC, et al: Histocompatibility typing in amyotrophic lateral sclerosis . Arch Neurol 1976;33:423-435.Crossref 4. Jokelainen M, Tulikainen A, Lapinleimu K: Polio antibodies and HLA antigens in amyotrophic lateral sclerosis . Tissue Antigens 1977;10:259-266.Crossref 5. Behan PO, Dick HM, Durward WF: Histocompatibility antigens associated with motor neuron disease . J Neurol Sci 1977;32:213-217.Crossref 6. Pederson L, Platz P, Jersild C, et al: HLA (SD and LD) in patients with amyotrophic lateral sclerosis (ALS) . J Neurol Sci 1977;31:313-318.Crossref 7. Antel JP, Noronha ABC, Oger JJ-F, et al: Immunology of amyotrophic lateral sclerosis , in Rowland LP (ed): Human Motor Neuron Diseases . New York, Raven Press, 1982, pp 395-400. 8. Hoffman PM, Robbins DS, Nolte MJ, et al: Cellular immunity in Guamanians with amyotrophic lateral sclerosis and Parkinsonism-dementia . N Engl J Med 1978;299:680-685.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Jan 1, 1986

References