Abstract • Twenty-two Japanese patients with glaucomatocyclitic crisis were typed for HLA-A, HLA-B, and HLA-C antigens to detect the immunogenetic factors in this disease. It was shown that HLA-Bw54 was present in nine (41%) of 22 patients, a significant increase even after correcting the P value for the number of antigens studied. The haplotype frequency of HLA-Bw54-Cw1 showed a significant association, and it was not due to linkage disequilibrium in the Japanese. Our results suggest that immunogenetic factors closely associated with the major histocompatibility complex may play an important role in the pathogenesis of glaucomatocyclitic crisis. References 1. Posner A, Schlossman A: Syndrome of unilateral recurrent attacks of glaucoma with cyclitis symptoms . Arch Ophthalmol 1948;39:517-535.Crossref 2. Posner A, Schlossman A: Further observations on the syndrome of glaucomatocyclitic crisis . Trans Am Acad Ophthalmol Otolaryngol 1953; 57:531-536. 3. Kass MA, Becker B, Kolker AE: Glaucomatocyclitic crisis and primary open-angle glaucoma . Am J Ophthalmol 1973;75:668-673. 4. Kraupa E: Die Drucksteigerung bei akuter Angioneurose des Ciliarkörpers ('Glaucoma allergicum') in ihren Beziehungen zum zyklitischen und Heterechromieglaukom . Arch Augenheilkd 1936;109:416-433. 5. Theodore FH: Observations on glaucomatocyclitic crisis . Br J Ophthalmol 1952;36:207-210.Crossref 6. Masuda K, Izawa Y, Mishima S: Prostaglandins and uveitis . Jpn J Ophthalmol 1973;17:166-170. 7. Nagataki S, Mishima S: Aqueous humor dynamics in glaucomatocyclitic crisis . Invest Ophthalmol Vis Sci 1976;15:365-370. 8. Raitta C, Vannas A: Glaucomatocyclitic crisis . Arch Ophthalmol 1977;95:608-612.Crossref 9. Ohno S, Aoki K, Sugiura S, et al: HL-A5 and Behçet's disease . Lancet 1973;2:1383-1384.Crossref 10. Ohno S, Nakayama E, Sugiura S, et al: Specific histocompatibility antigens associated with Behçet's disease . Am J Ophthalmol 1975; 80:636-641. 11. Ohno S, Char DH, Kimura SJ, et al: HLA antigens and antinuclear antibody titres in juvenile chronic iridocyclitis . Br J Ophthalmol 1977; 61:59-61.Crossref 12. Tagawa Y, Sugiura S, Yakura H, et al: HLA and Vogt-Koyanagi-Harada syndrome . Jpn J Ophthalmol 1977;21:23-37. 13. Ohno S: The association of the HLA system with ocular diseases . Jpn J Ophthalmol 1979; 23:355-373. 14. Tagawa Y: Study on HLA antigens in Vogt-Koyanagi-Harada disease . Acta Soc Ophthalmol Jpn 1979;83:162-166. 15. Ohno S: Immunological aspects of Behçet's and Vogt-Koyanagi-Harada's diseases . Trans Ophthalmol Soc UK 1981;101:335-341. 16. Ohno S, Ohguchi M, Hirose S, et al: Close association of HLA-Bw51 with Behçet's disease . Arch Ophthalmol 1982;100:1455-1458.Crossref 17. Ohno S, Ohguchi M, Hirose S, et al: Close association of HLA-Bw51, MT2 and Behçet's disease , in Inaba G (ed): Behçet's Disease . Tokyo, University of Tokyo Press, 1982, pp 73-79. 18. Hirose S, Ohno S, Ohguchi M, et al: HLA and Behçet's disease . Folia Ophthalmol Jpn 1983; 34:136-139. 19. Ray JG Jr, Hare DB, Pedersen PD, et al (eds): National Institutes of Health lymphocyte microcytotoxicity technique , in National Institute of Allergy and Infectious Diseases Manual of Tissue Typing Techniques . Bethesda, Md, National Institutes of Health, 1976, pp 22-24. 20. Woolf B: On estimating the relation between blood group and disease . Ann Hum Genet 1955;19:251-253.Crossref 21. Haldane JB: The estimation and significance of the logarithm of a ratio frequency . Ann Hum Genet 1956;20:309-311.Crossref 22. Mittal KK: The HLA polymorphism and susceptibility to disease . Vox Sang 1976;31:161-173.Crossref 23. Porta J, McHugh R: Detection of HLA haplotype association with disease . Tissue Antigens 1980;15:337-345.Crossref 24. Kawa A, Nakazawa M, Sakaguchi S, et al: HLA system in Japanese patients with diabetes mellitus . Diabetes 1977;26:591-595.Crossref 25. Kawa A, Nakazawa M, Kono Y, et al: HLA Bw54 and B5 in Japanese diabetics with juvenileonset and insulin dependency (with special reference to the family history) . Experientia 1978; 34:669-670.Crossref 26. Cudworth AG: Type I diabetes mellitus . Diabetologia 1978;14:281-291.Crossref 27. Green A: The epidemiologic approach to studies of association between HLA and disease: II. Estimation of absolute risks, etiologic and preventive fraction . Tissue Antigens 1982;19:259-268.Crossref 28. Dawkins RL, Christiansen FT, Kay PH, et al: Disease associations with complotypes, supratypes and haplotypes , in Moller G (ed): Immunological Reviews 70 . Copenhagen, Munksgaard, 1983, pp 5-22.
Archives of Ophthalmology – American Medical Association
Published: Dec 1, 1985
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