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HIV Prevention Trial in African Women Fails, Adherence a Problem

HIV Prevention Trial in African Women Fails, Adherence a Problem News & Analysis Global Health HIV Prevention Trial in African Women monal contraceptive (HC) use and incident Fails, Adherence a Problem HIV infection among women aged 15 to 49 Three antiretroviral products evaluated years living in sub-Saharan Africa (Morrison among African women in the Vaginal and CS et al. PLoS Med. 2015;12[1]:e1001778). Oral Interventions to Control the Epidemic More than 37 000 women were involved in (VOICE) HIV prevention trial were found to these studies, 1830 of whom became newly be safe but, because of poor adherence, infected with HIV. Nearly half of the women were not effective in preventing sexually ac- were not using HC (the comparison group), quired HIV (Marrazzo JM et al. N Engl J Med. 26% used depot-medroxyprogesterone ac- 2015;372[6]:509-518). etate, 16% used combined oral contracep- The VOICE trial, a study of tenofovir- tives (COC), and 9% used norethisterone basedpreexposureprophylaxiswithorwith- enanthate. out the oral antiretroviral therapy emtricit- Use of depot-medroxyprogesterone abinewasconductedfromSeptember2009 acetate was associated with an increased to August 2012. More than 5000 women risk of HIV acquisition compared with no aged 18 to 45 years who were from 15 clini- HC (HR, 1.5; 95% CI, 1.24-1.83), whereas A recent report from the UK makes http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

HIV Prevention Trial in African Women Fails, Adherence a Problem

JAMA , Volume 313 (11) – Mar 17, 2015

HIV Prevention Trial in African Women Fails, Adherence a Problem

Abstract

News & Analysis Global Health HIV Prevention Trial in African Women monal contraceptive (HC) use and incident Fails, Adherence a Problem HIV infection among women aged 15 to 49 Three antiretroviral products evaluated years living in sub-Saharan Africa (Morrison among African women in the Vaginal and CS et al. PLoS Med. 2015;12[1]:e1001778). Oral Interventions to Control the Epidemic More than 37 000 women were involved in (VOICE) HIV prevention trial were found to these studies, 1830 of...
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Publisher
American Medical Association
Copyright
Copyright 2015 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2015.2059
Publisher site
See Article on Publisher Site

Abstract

News & Analysis Global Health HIV Prevention Trial in African Women monal contraceptive (HC) use and incident Fails, Adherence a Problem HIV infection among women aged 15 to 49 Three antiretroviral products evaluated years living in sub-Saharan Africa (Morrison among African women in the Vaginal and CS et al. PLoS Med. 2015;12[1]:e1001778). Oral Interventions to Control the Epidemic More than 37 000 women were involved in (VOICE) HIV prevention trial were found to these studies, 1830 of whom became newly be safe but, because of poor adherence, infected with HIV. Nearly half of the women were not effective in preventing sexually ac- were not using HC (the comparison group), quired HIV (Marrazzo JM et al. N Engl J Med. 26% used depot-medroxyprogesterone ac- 2015;372[6]:509-518). etate, 16% used combined oral contracep- The VOICE trial, a study of tenofovir- tives (COC), and 9% used norethisterone basedpreexposureprophylaxiswithorwith- enanthate. out the oral antiretroviral therapy emtricit- Use of depot-medroxyprogesterone abinewasconductedfromSeptember2009 acetate was associated with an increased to August 2012. More than 5000 women risk of HIV acquisition compared with no aged 18 to 45 years who were from 15 clini- HC (HR, 1.5; 95% CI, 1.24-1.83), whereas A recent report from the UK makes

Journal

JAMAAmerican Medical Association

Published: Mar 17, 2015

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