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HISTOPLASMIN SENSITIVITY

HISTOPLASMIN SENSITIVITY IN A STUDY of children in Tennessee in 1942 Gass and his associates1 observed that many children exhibiting negative reactions in tuberculin tests had pulmonary calcifications. Later, Christie2 reported the same observation and began a search for a condition other than tuberculosis as a cause of these lesions. On the basis of reports that in the western states coccidioidomycosis caused pulmonary calcifications, he tested the reactions in his patients to various fungous antigens. Although none of the children gave strongly positive reactions to coccidioidin, many gave positive reactions to histoplasmin, an antigen made from Histoplasma capsulatum. The purposes of this study were to determine the percentage among the school children in an Alabama city who gave positive reactions to histoplasmin and to tuberculin, and also to study the roentgenograms of those with positive reactions in the tests. Of 1,200 Negro children in grammar school in a crowded area http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1947 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1947.02030010621005
Publisher site
See Article on Publisher Site

Abstract

IN A STUDY of children in Tennessee in 1942 Gass and his associates1 observed that many children exhibiting negative reactions in tuberculin tests had pulmonary calcifications. Later, Christie2 reported the same observation and began a search for a condition other than tuberculosis as a cause of these lesions. On the basis of reports that in the western states coccidioidomycosis caused pulmonary calcifications, he tested the reactions in his patients to various fungous antigens. Although none of the children gave strongly positive reactions to coccidioidin, many gave positive reactions to histoplasmin, an antigen made from Histoplasma capsulatum. The purposes of this study were to determine the percentage among the school children in an Alabama city who gave positive reactions to histoplasmin and to tuberculin, and also to study the roentgenograms of those with positive reactions in the tests. Of 1,200 Negro children in grammar school in a crowded area

Journal

American journal of diseases of childrenAmerican Medical Association

Published: Nov 1, 1947

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