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Histopathological Findings in Clinical Gentamicin Ototoxicity

Histopathological Findings in Clinical Gentamicin Ototoxicity Abstract • The temporal bone histopathological findings in a case of gentamicin sulfateinduced hearing loss and vertigo in an anephric patient undergoing hemodialysis are presented. A study of the sensory neuroepithelium of the cristae and maculae disclosed the presence of vacuoles with clubbing of the sensory cells. In the cochlea, loss of the innermost row of outer hair cells in the basal turn was the most prominent feature. These findings are discussed in light of reports of similar morphological changes in laboratory studies of gentamicin ototoxicity. (Arch Otolaryngol 1982;108:65-70) References 1. Weinstein MJ, Luedemann GM, Oden EM, et al: Gentamicin: A new antibiotic complex from Micromonospora . J Med Chem 1963;6:463-464.Crossref 2. Lundquist PG, Wersäll J: The ototoxic effect of gentamicin: An electron microscopical study , in Proceedings of the First International Symposium on Gentamicin . Lucerne, Switzerland, Essex Chemie AG, 1967, pp 26-46. 3. Myers RM: Ototoxic effects of gentamicin . Arch Otolaryngol 1970;92:160-162.Crossref 4. Fee WE: Aminoglycoside ototoxicity in the human . Laryngoscope 1980;90: (24) :1-19.Crossref 5. Barber HO, Stockwell CW: Manual of Electronystagmography , ed 2. St Louis, CV Mosby Co, 1980. 6. Gussen R, Donahue D: Decalcification of temporal bones with tetrasodium edetate . Arch Otolaryngol 1965;82:110-114.Crossref 7. Hawke M, Farkashidy J, Jahn A, et al: Processing and staining technique for light microscopic examination of the human temporal bone . Can J Otolaryngol 1973;2:143-150. 8. Guild SR: A graphic reconstruction method for the study of the organ of Corti . Anat Rec 1921;22:141-157.Crossref 9. Bergstrom L, Thompson P, Sando I, et al: Renal disease: Its pathology, treatment and effects on the ear . Arch Otolaryngol 1980;106:567-572.Crossref 10. Laitakari K: Vestibular disorders in medically managed chronic renal insufficiency . Acta Otolaryngol 1977;349:1-30. 11. Fernandez C: Post mortem changes and artifacts in human temporal bones . Laryngoscope 1958;68:1585-1615.Crossref 12. Keene M, Hawke M: The pathogenesis and detection of aminoglycoside ototoxicity . J Otolaryngol 1981;10:228-236. 13. Schacht J: Interaction of neomycin with phosphoinositide metabolism in guinea pig inner ear and brain tissues . Ann Otolaryngol 1974;83:613-618. 14. Dayal VS, Smith EL, McCain G: Cochlear and vestibular gentamicin toxicity: A clinical study of systemic and topical usage . Arch Otolaryngol 1974;100:338-340.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

Histopathological Findings in Clinical Gentamicin Ototoxicity

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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1982.00790500001001
Publisher site
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Abstract

Abstract • The temporal bone histopathological findings in a case of gentamicin sulfateinduced hearing loss and vertigo in an anephric patient undergoing hemodialysis are presented. A study of the sensory neuroepithelium of the cristae and maculae disclosed the presence of vacuoles with clubbing of the sensory cells. In the cochlea, loss of the innermost row of outer hair cells in the basal turn was the most prominent feature. These findings are discussed in light of reports of similar morphological changes in laboratory studies of gentamicin ototoxicity. (Arch Otolaryngol 1982;108:65-70) References 1. Weinstein MJ, Luedemann GM, Oden EM, et al: Gentamicin: A new antibiotic complex from Micromonospora . J Med Chem 1963;6:463-464.Crossref 2. Lundquist PG, Wersäll J: The ototoxic effect of gentamicin: An electron microscopical study , in Proceedings of the First International Symposium on Gentamicin . Lucerne, Switzerland, Essex Chemie AG, 1967, pp 26-46. 3. Myers RM: Ototoxic effects of gentamicin . Arch Otolaryngol 1970;92:160-162.Crossref 4. Fee WE: Aminoglycoside ototoxicity in the human . Laryngoscope 1980;90: (24) :1-19.Crossref 5. Barber HO, Stockwell CW: Manual of Electronystagmography , ed 2. St Louis, CV Mosby Co, 1980. 6. Gussen R, Donahue D: Decalcification of temporal bones with tetrasodium edetate . Arch Otolaryngol 1965;82:110-114.Crossref 7. Hawke M, Farkashidy J, Jahn A, et al: Processing and staining technique for light microscopic examination of the human temporal bone . Can J Otolaryngol 1973;2:143-150. 8. Guild SR: A graphic reconstruction method for the study of the organ of Corti . Anat Rec 1921;22:141-157.Crossref 9. Bergstrom L, Thompson P, Sando I, et al: Renal disease: Its pathology, treatment and effects on the ear . Arch Otolaryngol 1980;106:567-572.Crossref 10. Laitakari K: Vestibular disorders in medically managed chronic renal insufficiency . Acta Otolaryngol 1977;349:1-30. 11. Fernandez C: Post mortem changes and artifacts in human temporal bones . Laryngoscope 1958;68:1585-1615.Crossref 12. Keene M, Hawke M: The pathogenesis and detection of aminoglycoside ototoxicity . J Otolaryngol 1981;10:228-236. 13. Schacht J: Interaction of neomycin with phosphoinositide metabolism in guinea pig inner ear and brain tissues . Ann Otolaryngol 1974;83:613-618. 14. Dayal VS, Smith EL, McCain G: Cochlear and vestibular gentamicin toxicity: A clinical study of systemic and topical usage . Arch Otolaryngol 1974;100:338-340.Crossref

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: Feb 1, 1982

References