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Histopathologic Study of Nine Branch Retinal Vein Occlusions

Histopathologic Study of Nine Branch Retinal Vein Occlusions Abstract • Occlusions of nine branch retinal veins in eight eyes of seven patients were studied histopathologically by serial sections through the affected areas. Intravitreal neovascularization from the disc, retina, or both was noted in four eyes. Two additional eyes had intraretinal neovascularization (intraretinal microvascular abnormalities). Cystoid macular edema was present in five eyes. A fresh or recanalized thrombus was noted at the site of vein occlusion in all eyes. Inner ischemic atrophy of the retina was found distal to the area of occlusion in six of the nine affected quadrants of the eight eyes. Although the corresponding branch retinal arteries showed varying degrees of sclerosis (severe, three eyes; moderate, five eyes; and minimal, one eye), no definite thrombus was observed in any of them. References 1. Gutman FA, Zegarra H: The natural course of temporal retinal branch vein occlusion . Trans Am Acad Ophthalmol Otolaryngol 1974;78:178-192. 2. Jensen VA: Clinical studies of tributary thrombosis in the central retinal vein . Acta Ophthalmol Suppl 1936;10:1-193. 3. Blankenship GW, Okun E: Retinal tributary vein occlusion: History and management by photocoagulation . Arch Ophthalmol 1973;89:363-368.Crossref 4. Leber T: Die Krankheite der Netzhaut und des Sehnerven , in Handbuch der gesamten Augenheilkde . Leipzig, Germany, Graefe-Saemisch, 1877, vol 5, p 531. 5. Michels RG, Gass JDM: The natural course of retinal branch vein obstruction . Trans Am Acad Ophthalmol Otolaryngol 1974;78:166-177. 6. Duff IF, Falls HF, Linman JW: Anticoagulant therapy in occlusive vascular disease of the retina . Arch Ophthalmol 1951;46:601-617.Crossref 7. Vannas S, Raitta C: Anticoagulant treatment of retinal venous occlusion . Am J Ophthalmol 1966;62:874-884. 8. Shilling JS, Kohner EM: New vessel formation in retinal branch vein occlusion . Br J Ophthalmol 1976;60:810-815.Crossref 9. Orth DH, Patz A: Retinal branch vein occlusion . Surv Ophthalmol 1978;22:357-376.Crossref 10. Seitz R: The Retinal Vessels , Blodi FC (trans-ed). St Louis, CV Mosby Co, 1964, pp 88-94. 11. Rabinowicz IM, Litman S, Michaelson IC: Branch venous thrombosis: A pathological report . Trans Ophthalmol Soc UK 1968;88:191-210. 12. Kornzweig AL, Eliasoph I, Feldstein M: Occlusive disease of retinal vasculature: A clinicopathological study . Arch Ophthalmol 1964; 71:542-551.Crossref 13. Vaghefi HA, Green WR, Kelley JS, et al: Correlation of clinicopathologic findings in a patient: Congenital night blindness, branch retinal vein occlusion, cilioretinal artery, drusen of the optic nerve head, and intraretinal pigmented lesion . Arch Ophthalmol 1978;96:2097-2104.Crossref 14. Wise GN: Arteriosclerosis secondary to retinal vein obstruction . Trans Am Acad Ophthalmol Soc 1958;56:361-382. 15. Kohner EM, Dollery CT, Shakib M, et al: Experimental retinal branch vein occlusion . Am J Ophthalmol 1970;69:778-825. 16. Hamilton AM, Kohner EM, Rosen D, et al: Experimental retinal branch vein occlusion in rhesus monkeys: I. Clinical appearances . Br J Ophthalmol 1979;63:377-387.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Histopathologic Study of Nine Branch Retinal Vein Occlusions

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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1982.01030040110020
Publisher site
See Article on Publisher Site

Abstract

Abstract • Occlusions of nine branch retinal veins in eight eyes of seven patients were studied histopathologically by serial sections through the affected areas. Intravitreal neovascularization from the disc, retina, or both was noted in four eyes. Two additional eyes had intraretinal neovascularization (intraretinal microvascular abnormalities). Cystoid macular edema was present in five eyes. A fresh or recanalized thrombus was noted at the site of vein occlusion in all eyes. Inner ischemic atrophy of the retina was found distal to the area of occlusion in six of the nine affected quadrants of the eight eyes. Although the corresponding branch retinal arteries showed varying degrees of sclerosis (severe, three eyes; moderate, five eyes; and minimal, one eye), no definite thrombus was observed in any of them. References 1. Gutman FA, Zegarra H: The natural course of temporal retinal branch vein occlusion . Trans Am Acad Ophthalmol Otolaryngol 1974;78:178-192. 2. Jensen VA: Clinical studies of tributary thrombosis in the central retinal vein . Acta Ophthalmol Suppl 1936;10:1-193. 3. Blankenship GW, Okun E: Retinal tributary vein occlusion: History and management by photocoagulation . Arch Ophthalmol 1973;89:363-368.Crossref 4. Leber T: Die Krankheite der Netzhaut und des Sehnerven , in Handbuch der gesamten Augenheilkde . Leipzig, Germany, Graefe-Saemisch, 1877, vol 5, p 531. 5. Michels RG, Gass JDM: The natural course of retinal branch vein obstruction . Trans Am Acad Ophthalmol Otolaryngol 1974;78:166-177. 6. Duff IF, Falls HF, Linman JW: Anticoagulant therapy in occlusive vascular disease of the retina . Arch Ophthalmol 1951;46:601-617.Crossref 7. Vannas S, Raitta C: Anticoagulant treatment of retinal venous occlusion . Am J Ophthalmol 1966;62:874-884. 8. Shilling JS, Kohner EM: New vessel formation in retinal branch vein occlusion . Br J Ophthalmol 1976;60:810-815.Crossref 9. Orth DH, Patz A: Retinal branch vein occlusion . Surv Ophthalmol 1978;22:357-376.Crossref 10. Seitz R: The Retinal Vessels , Blodi FC (trans-ed). St Louis, CV Mosby Co, 1964, pp 88-94. 11. Rabinowicz IM, Litman S, Michaelson IC: Branch venous thrombosis: A pathological report . Trans Ophthalmol Soc UK 1968;88:191-210. 12. Kornzweig AL, Eliasoph I, Feldstein M: Occlusive disease of retinal vasculature: A clinicopathological study . Arch Ophthalmol 1964; 71:542-551.Crossref 13. Vaghefi HA, Green WR, Kelley JS, et al: Correlation of clinicopathologic findings in a patient: Congenital night blindness, branch retinal vein occlusion, cilioretinal artery, drusen of the optic nerve head, and intraretinal pigmented lesion . Arch Ophthalmol 1978;96:2097-2104.Crossref 14. Wise GN: Arteriosclerosis secondary to retinal vein obstruction . Trans Am Acad Ophthalmol Soc 1958;56:361-382. 15. Kohner EM, Dollery CT, Shakib M, et al: Experimental retinal branch vein occlusion . Am J Ophthalmol 1970;69:778-825. 16. Hamilton AM, Kohner EM, Rosen D, et al: Experimental retinal branch vein occlusion in rhesus monkeys: I. Clinical appearances . Br J Ophthalmol 1979;63:377-387.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Jul 1, 1982

References