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HISTOPATHOLOGIC STUDIES IN EXPERIMENTAL POLIOMYELITIS

HISTOPATHOLOGIC STUDIES IN EXPERIMENTAL POLIOMYELITIS Abstract Evidence has accumulated to indicate that poliomyelitis is propagated within the central nervous system along axonal channels and that the clinical manifestations of the disease are explainable on the basis of advance of the infection solely through and within the nervous system. The excellent studies of Hurst1 and Pette, Demme and Környey2 disclosed that the early spread of virus within the neuraxis after experimental intraneural inoculation follows rather narrowly a unilateral, decussating pathway. After unilateral intracerebral inoculation the early cerebral lesions are more marked ipsilaterally (Fairbrother and Hurst3), and the lesions in the spinal cord are more severe contralaterally (Pette and his associates2). In the present study an endeavor was made to establish the nature and pattern of distribution of the histopathologic process in fully developed experimental poliomyelitis following intracerebral inoculation with a particular strain of virus and to study the evolution of the histopathologic changes References 1. Hurst, E. Weston: A Further Contribution to the Pathogenesis of Experimental Poliomyelitis: Inoculation into the Sciatic Nerve , J. Path. & Bact. 33:1133, 1930. 2. Pette, H.; Demme, H., and Környey, St.: Studien über experimentelle Poliomyelitis , Deutsche Ztschr. f. Nervenh. 128:125, 1932. 3. Fairbrother, R. W., and Hurst, E. Weston: The Pathogenesis of, and Propagation of the Virus in, Experimental Poliomyelitis , J. Path. & Bact. 33:17, 1930. 4. Rhoads, C. P.: Intradermal Immunization of Monkeys with One Set of Injections of Poliomyelitis Virus , J. Exper. Med. 51:1, 1930. 5. Harmon, Paul H.; Shaughnessy, Howard J., and Gordon, Francis B.: Preparalytic Poliomyelitis in the Monkey: Changes in Temperature, Spinal Fluid, Blood and Erythrocyte Sedimentation , J. Prev. Med. 5:115, 1931. 6. Brodie, Maurice, and Wortis, S. Bernard: Experimental Poliomyelitis: Cytologic Studies of the Cerebrospinal Fluid and the Respiratory Metabolism of the Excised Spinal Cord and Brain , Arch. Neurol. & Psychiat. 32:1159 ( (Dec.) ) 1934. 7. Weil, Arthur, and Davenport, Harold A.: Staining of Oligodendroglia and Microglia in Celloidin Sections , Arch. Neurol. & Psychiat. 30:175 ( (July) ) 1933. 8. Davenport, H. A.: Staining Nerve Fibers in Mounted Sections with Alcoholic Silver Nitrate Solution , Arch. Neurol. & Psychiat. 24:690 ( (Oct.) ) 1930. 9. Clarke, R. H., and Henderson, E. E.: Investigation of the Central Nervous System: II. Atlas of Photographs of the Frontal Sections of the Cranium and Brain of the Rhesus Monkey (Macacus Rhesus) , Special Volume, Johns Hopkins Hospital Rep., Baltimore, Johns Hopkins Press, 1920. 10. Hurst, E. Weston: The Histology of Experimental Poliomyelitis , J. Path. & Bact. 32:457, 1929. 11. Környey, St.: Zur Histopathologie der menschlichen Poliomyelitis , Deutsche Ztschr. f. Nervenh. 130:74, 1933. 12. Spielmeyer, W.: Zur Histopathologie und Pathogenese der Poliomyelitis , Ztschr. f. d. ges. Neurol. u. Psychiat. 142:159, 1932. 13. Marinesco, G.; Manicatide, M., and State-Draganesco: Etude clinicothérapeutique et anatomo-pathologique sur l'épidémie de paralysie infantile qui a sévi en Roumanie pendant l'année 1927 , Ann. Inst. Pasteur 43:223, 1929. 14. Landon, John F., and Smith, Lawrence W.: Poliomyelitis: A Handbook for Physicians and Medical Students , New York, The Macmillan Company, 1934. 15. Wöhrmann, W.: Ueber Poliomyelitis anterior acuta , Virchows Arch. f. path. Anat. 259:466, 1926. 16. Landsteiner, K.; Levaditi, C., and Pastia, M.: Etude expérimentale de la poliomyélite aiguë (maladie de Heine-Medin): Second mémoire , Ann. Inst. Pasteur 25:805, 1911. 17. Rosenow, E. C.; Towne, E. B., and Wheeler, G. W.: The Etiology of Epidemic Poliomyelitis: Preliminary Note , J. A. M. A. 67:1202 ( (Oct. 21) ) 1916. 18. Eberson, F.: Etiology of Poliomyelitis: Cultivation of an Organism from Poliomyelitic Tissue and Transmission of the Disease in Monkeys , Proc. Soc. Exper. Biol. & Med. 29:477, 1932 19. Studies on the Etiology of Poliomyelitis: Isolation and Cultivation of an Organism and Transmission of the Disease in Monkeys , Science 75:519, 1932. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

HISTOPATHOLOGIC STUDIES IN EXPERIMENTAL POLIOMYELITIS

Archives of Neurology & Psychiatry , Volume 37 (3) – Mar 1, 1937

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Publisher
American Medical Association
Copyright
Copyright © 1937 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1937.02260150009001
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Abstract

Abstract Evidence has accumulated to indicate that poliomyelitis is propagated within the central nervous system along axonal channels and that the clinical manifestations of the disease are explainable on the basis of advance of the infection solely through and within the nervous system. The excellent studies of Hurst1 and Pette, Demme and Környey2 disclosed that the early spread of virus within the neuraxis after experimental intraneural inoculation follows rather narrowly a unilateral, decussating pathway. After unilateral intracerebral inoculation the early cerebral lesions are more marked ipsilaterally (Fairbrother and Hurst3), and the lesions in the spinal cord are more severe contralaterally (Pette and his associates2). In the present study an endeavor was made to establish the nature and pattern of distribution of the histopathologic process in fully developed experimental poliomyelitis following intracerebral inoculation with a particular strain of virus and to study the evolution of the histopathologic changes References 1. Hurst, E. Weston: A Further Contribution to the Pathogenesis of Experimental Poliomyelitis: Inoculation into the Sciatic Nerve , J. Path. & Bact. 33:1133, 1930. 2. Pette, H.; Demme, H., and Környey, St.: Studien über experimentelle Poliomyelitis , Deutsche Ztschr. f. Nervenh. 128:125, 1932. 3. Fairbrother, R. W., and Hurst, E. Weston: The Pathogenesis of, and Propagation of the Virus in, Experimental Poliomyelitis , J. Path. & Bact. 33:17, 1930. 4. Rhoads, C. P.: Intradermal Immunization of Monkeys with One Set of Injections of Poliomyelitis Virus , J. Exper. Med. 51:1, 1930. 5. Harmon, Paul H.; Shaughnessy, Howard J., and Gordon, Francis B.: Preparalytic Poliomyelitis in the Monkey: Changes in Temperature, Spinal Fluid, Blood and Erythrocyte Sedimentation , J. Prev. Med. 5:115, 1931. 6. Brodie, Maurice, and Wortis, S. Bernard: Experimental Poliomyelitis: Cytologic Studies of the Cerebrospinal Fluid and the Respiratory Metabolism of the Excised Spinal Cord and Brain , Arch. Neurol. & Psychiat. 32:1159 ( (Dec.) ) 1934. 7. Weil, Arthur, and Davenport, Harold A.: Staining of Oligodendroglia and Microglia in Celloidin Sections , Arch. Neurol. & Psychiat. 30:175 ( (July) ) 1933. 8. Davenport, H. A.: Staining Nerve Fibers in Mounted Sections with Alcoholic Silver Nitrate Solution , Arch. Neurol. & Psychiat. 24:690 ( (Oct.) ) 1930. 9. Clarke, R. H., and Henderson, E. E.: Investigation of the Central Nervous System: II. Atlas of Photographs of the Frontal Sections of the Cranium and Brain of the Rhesus Monkey (Macacus Rhesus) , Special Volume, Johns Hopkins Hospital Rep., Baltimore, Johns Hopkins Press, 1920. 10. Hurst, E. Weston: The Histology of Experimental Poliomyelitis , J. Path. & Bact. 32:457, 1929. 11. Környey, St.: Zur Histopathologie der menschlichen Poliomyelitis , Deutsche Ztschr. f. Nervenh. 130:74, 1933. 12. Spielmeyer, W.: Zur Histopathologie und Pathogenese der Poliomyelitis , Ztschr. f. d. ges. Neurol. u. Psychiat. 142:159, 1932. 13. Marinesco, G.; Manicatide, M., and State-Draganesco: Etude clinicothérapeutique et anatomo-pathologique sur l'épidémie de paralysie infantile qui a sévi en Roumanie pendant l'année 1927 , Ann. Inst. Pasteur 43:223, 1929. 14. Landon, John F., and Smith, Lawrence W.: Poliomyelitis: A Handbook for Physicians and Medical Students , New York, The Macmillan Company, 1934. 15. Wöhrmann, W.: Ueber Poliomyelitis anterior acuta , Virchows Arch. f. path. Anat. 259:466, 1926. 16. Landsteiner, K.; Levaditi, C., and Pastia, M.: Etude expérimentale de la poliomyélite aiguë (maladie de Heine-Medin): Second mémoire , Ann. Inst. Pasteur 25:805, 1911. 17. Rosenow, E. C.; Towne, E. B., and Wheeler, G. W.: The Etiology of Epidemic Poliomyelitis: Preliminary Note , J. A. M. A. 67:1202 ( (Oct. 21) ) 1916. 18. Eberson, F.: Etiology of Poliomyelitis: Cultivation of an Organism from Poliomyelitic Tissue and Transmission of the Disease in Monkeys , Proc. Soc. Exper. Biol. & Med. 29:477, 1932 19. Studies on the Etiology of Poliomyelitis: Isolation and Cultivation of an Organism and Transmission of the Disease in Monkeys , Science 75:519, 1932.

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: Mar 1, 1937

References