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Histopathologic Review of Salivary Gland Tumors in Childhood

Histopathologic Review of Salivary Gland Tumors in Childhood Abstract • During the 58-year period from 1928 through 1986, 80 patients 18 years of age or younger were treated or seen in consultation at Children's Hospital, Boston, for an epithelial or nonepithelial tumor of salivary gland origin. Using established criteria, ten (40%) of the 25 epithelial tumors were pleomorphic adenomas and the remaining tumors were classified as histologically malignant growths including mucoepidermoid carcinoma (n = 6), acinic cell carcinoma (n = 5), and adenocarcinoma most likely of duct cell origin (n = 2). Two other carcinomas presented as congenital parotid salivary gland tumors in newborns and were considered to have biphasic composition including both epithelial and myoepithelial cells, with the latter type predominating. There was only one tumor-related death due to metastases among the 15 children with malignant epithelial tumors (7%); four other patients experienced a local recurrence of tumor (27%). Of the 55 nonepithelial tumors, capillary hemangioma was the most common and showed distinct predilection for female infants with localization in the left parotid gland. The histologic spectrum of primary salivary gland tumors in infancy and childhood is distinctive and merits careful correlation with therapeutic strategies. (Arch Otolaryngol Head Neck Surg 1988;114:898-906) References 1. Castro EB, Huvos AG, Strong EW, et al: Tumors of the major salivary glands in children . Cancer 1972;29:312-317.Crossref 2. Beahrs OH, Chong GC: Management of the facial nerve in parotid gland surgery . Am J Surg 1972;124:473-476.Crossref 3. Thackray AC, Sobin LH: Histological Typing of Salivary Gland Tumors . Geneva, World Health Organization, 1972. 4. Thackray AC, Lucas RB: Tumors of the Major Salivary Glands . Atlas of Tumor Pathology, Armed Forces Institute of Pathology. 1974, series 2. 5. Eveson JW, Cawson RA: Salivary gland tumors: A review of 2410 cases with particular reference to histological types, site, age and sex distribution . J Pathol 1985;146:51-58.Crossref 6. Galich R: Salivary gland neoplasms in childhood . Arch Otolaryngol Head Neck Surg 1969; 89:100-104.Crossref 7. Chong GC, Beahrs OH, Chen MLC, et al: Managements of parotid gland tumors in infants and children . Mayo Clin Proc 1975;50:279-283. 8. Krolls SO, Trodahl JN, Boyers RC: Salivary gland lesions in children: A survey of 430 cases . Cancer 1972;30:459-468.Crossref 9. Baker SK, Malone B: Salivary gland malignancies in children . Cancer 1985;55:1730-1736.Crossref 10. Conley J, Tinsley PP Jr: Treatment and prognosis of mucoepidermoid carcinoma in the pediatric age group . Arch Otolaryngol Head Neck Surg 1985;111:322-324.Crossref 11. Ellis GL, Corio RL: Acinic cell adenocarcinoma: A clinicopathologic study of 294 cases . Cancer 1983;52:542-549.Crossref 12. Spiro RH, Huvos AG, Strong EW: Acinic cell carcinoma of salivary origin: A clinicopathologic study of 67 cases . Cancer 1978;41:924-935.Crossref 13. Levene SB, Potsic WP: Acinic cell carcinoma of the parotid gland in children . Int J Pediatr Otorhinolaryngol 1986;11:281-286.Crossref 14. Tran L, Sageghi A, Juillard G, et al: Major salivary gland tumors: Treatment results and prognostic factors . Laryngoscope 1986;96:1139-1144.Crossref 15. Vawter GF, Tefft M: Congenital tumors of the parotid gland . Arch Pathol Lab Med 1966; 82:242-245. 16. Corio RL, Sciubba JJ, Brannon RB, et al: Epithelial-myoepithelial carcinoma of intercalated duct origin: A clinicopathologic and ultrastructural assessment of 16 cases . Oral Surg Oral Med Oral Pathol 1982;53:280-287.Crossref 17. Donath K, Seifert G, Schmitz R: Zur Diagnose und Ultrastruktur des tubularen speichlgangcarcinoms: Epithelial-myoepitheliales schaltstuckcarcinom . Virchows Arch A 1972;356:16-31.Crossref 18. Nagao K, Matsuzaki O, Shigematsu H, et al: Histopathologic studies of benign infantile hemangioendothelioma of the parotid gland . Cancer 1980;46:2250-2256.Crossref 19. Batsakis JG: Vascular tumors of the salivary glands . Ann Otol Rhinol Laryngol 1986; 95:649-650. 20. Tomec R, Ahmad I, Fu YS, et al: Malignant hemangioendothelioma (angiosarcoma) of the salivary gland: An ultrastructural study . Cancer 1979;43:1664-1671.Crossref 21. Auclair PL, Langloss JM, Weiss SW, et al: Sarcomas and sarcomatoid neoplasms of the major salivary gland regions: A clinicopathologic and immunohistochemical study of 67 cases and review of the literature . Cancer 1986;58:1305-1315.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology - Head & Neck Surgery American Medical Association

Histopathologic Review of Salivary Gland Tumors in Childhood

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Publisher
American Medical Association
Copyright
Copyright © 1988 American Medical Association. All Rights Reserved.
ISSN
0886-4470
eISSN
1538-361X
DOI
10.1001/archotol.1988.01860200082024
Publisher site
See Article on Publisher Site

Abstract

Abstract • During the 58-year period from 1928 through 1986, 80 patients 18 years of age or younger were treated or seen in consultation at Children's Hospital, Boston, for an epithelial or nonepithelial tumor of salivary gland origin. Using established criteria, ten (40%) of the 25 epithelial tumors were pleomorphic adenomas and the remaining tumors were classified as histologically malignant growths including mucoepidermoid carcinoma (n = 6), acinic cell carcinoma (n = 5), and adenocarcinoma most likely of duct cell origin (n = 2). Two other carcinomas presented as congenital parotid salivary gland tumors in newborns and were considered to have biphasic composition including both epithelial and myoepithelial cells, with the latter type predominating. There was only one tumor-related death due to metastases among the 15 children with malignant epithelial tumors (7%); four other patients experienced a local recurrence of tumor (27%). Of the 55 nonepithelial tumors, capillary hemangioma was the most common and showed distinct predilection for female infants with localization in the left parotid gland. The histologic spectrum of primary salivary gland tumors in infancy and childhood is distinctive and merits careful correlation with therapeutic strategies. (Arch Otolaryngol Head Neck Surg 1988;114:898-906) References 1. Castro EB, Huvos AG, Strong EW, et al: Tumors of the major salivary glands in children . Cancer 1972;29:312-317.Crossref 2. Beahrs OH, Chong GC: Management of the facial nerve in parotid gland surgery . Am J Surg 1972;124:473-476.Crossref 3. Thackray AC, Sobin LH: Histological Typing of Salivary Gland Tumors . Geneva, World Health Organization, 1972. 4. Thackray AC, Lucas RB: Tumors of the Major Salivary Glands . Atlas of Tumor Pathology, Armed Forces Institute of Pathology. 1974, series 2. 5. Eveson JW, Cawson RA: Salivary gland tumors: A review of 2410 cases with particular reference to histological types, site, age and sex distribution . J Pathol 1985;146:51-58.Crossref 6. Galich R: Salivary gland neoplasms in childhood . Arch Otolaryngol Head Neck Surg 1969; 89:100-104.Crossref 7. Chong GC, Beahrs OH, Chen MLC, et al: Managements of parotid gland tumors in infants and children . Mayo Clin Proc 1975;50:279-283. 8. Krolls SO, Trodahl JN, Boyers RC: Salivary gland lesions in children: A survey of 430 cases . Cancer 1972;30:459-468.Crossref 9. Baker SK, Malone B: Salivary gland malignancies in children . Cancer 1985;55:1730-1736.Crossref 10. Conley J, Tinsley PP Jr: Treatment and prognosis of mucoepidermoid carcinoma in the pediatric age group . Arch Otolaryngol Head Neck Surg 1985;111:322-324.Crossref 11. Ellis GL, Corio RL: Acinic cell adenocarcinoma: A clinicopathologic study of 294 cases . Cancer 1983;52:542-549.Crossref 12. Spiro RH, Huvos AG, Strong EW: Acinic cell carcinoma of salivary origin: A clinicopathologic study of 67 cases . Cancer 1978;41:924-935.Crossref 13. Levene SB, Potsic WP: Acinic cell carcinoma of the parotid gland in children . Int J Pediatr Otorhinolaryngol 1986;11:281-286.Crossref 14. Tran L, Sageghi A, Juillard G, et al: Major salivary gland tumors: Treatment results and prognostic factors . Laryngoscope 1986;96:1139-1144.Crossref 15. Vawter GF, Tefft M: Congenital tumors of the parotid gland . Arch Pathol Lab Med 1966; 82:242-245. 16. Corio RL, Sciubba JJ, Brannon RB, et al: Epithelial-myoepithelial carcinoma of intercalated duct origin: A clinicopathologic and ultrastructural assessment of 16 cases . Oral Surg Oral Med Oral Pathol 1982;53:280-287.Crossref 17. Donath K, Seifert G, Schmitz R: Zur Diagnose und Ultrastruktur des tubularen speichlgangcarcinoms: Epithelial-myoepitheliales schaltstuckcarcinom . Virchows Arch A 1972;356:16-31.Crossref 18. Nagao K, Matsuzaki O, Shigematsu H, et al: Histopathologic studies of benign infantile hemangioendothelioma of the parotid gland . Cancer 1980;46:2250-2256.Crossref 19. Batsakis JG: Vascular tumors of the salivary glands . Ann Otol Rhinol Laryngol 1986; 95:649-650. 20. Tomec R, Ahmad I, Fu YS, et al: Malignant hemangioendothelioma (angiosarcoma) of the salivary gland: An ultrastructural study . Cancer 1979;43:1664-1671.Crossref 21. Auclair PL, Langloss JM, Weiss SW, et al: Sarcomas and sarcomatoid neoplasms of the major salivary gland regions: A clinicopathologic and immunohistochemical study of 67 cases and review of the literature . Cancer 1986;58:1305-1315.Crossref

Journal

Archives of Otolaryngology - Head & Neck SurgeryAmerican Medical Association

Published: Aug 1, 1988

References