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Histopathologic Findings in Anetoderma

Histopathologic Findings in Anetoderma Abstract • We reviewed the histopathologic findings in 34 biopsy specimens from 15 patients with anetoderma. Focal loss of normal elastic fibers, necessary for the diagnosis of anetoderma, was found in all 15 cases. The persistence of fine, irregular, or twisted elastic fibers is common. A perivascular infiltrate composed of lymphocytes was found in all specimens. Plasma cells were observed in specimens from six patients, and histiocytes with some granuloma formation were found in specimens from six patients. Variations in the intensity of inflammation or in the loss of elastic tissue were not related to the clinical findings, course, or associated diseases. All anetoderma lesions appeared to have an inflammatory pathogenesis. (Arch Dermatol 1984;120:1040-1044) References 1. Jadassohn J: Ueber eine eigenartige Form von `Atrophia maculosa cutis.' Arch Dermatol Syph 1892, (suppl 1) , pp 342-358. 2. Schweninger E, Buzzi F: Multiple benign tumour-like new growths on the skin , in Unna PG, Morris M, Besner E, et al (eds): International Atlas of Rare Skin Diseasis . Hamburg, Germany, Leopold Voss, 1889-1899, vol 5, chap 15, pt (1) , plate 15, pp 4-5. 3. Deluzenne R: Les anétodermies maculeuses . Ann Dermatol Syphiligr 1956;83:618-630. 4. Korting GW, Cabré J, Holzmann H: Zur Kenntnis der Kollagenveränderungen bei der Anetodermie vom Typus Schweninger-Buzzi . Arch Klin Exp Dermatol 1964;218:274-297.Crossref 5. Cabré J: A propos du tableau histologique de l'anétodermie du type Schweninger-Buzzi , in Les maladies du tissu élastique cutané (12th Congrès de l'Association des Dermatologistes et Syphiligraphes de Langue Française, Paris, June 1965) . Paris, Masson & Cie, 1968, pp 340-343. 6. Götz H, Schuppener H-J: V. Anetodermie , in Handbuch der Haut-und Geschlechtskrankheiten . Berlin, Springer-Verlag Inc, 1969, vol 3, pt (2) , pp 480-488. 7. Venencie PY, Winkelmann RK, Moore BA: Anetoderma: Clinical findings, associations, and long-term follow-up evaluations . Arch Dermatol 1984;120:1032-1039.Crossref 8. Touraine A: Anétodermie urticarienne type Pellizzari (Sa place parmi les atrophies cutanées maculeuses) . Bull Soc Fr Dermatol Syphiligr 1941;48:602-608. 9. Nanko H, Voss Jepsen L, Zachariae H, et al: Acquired cutis laxa (generalized elastolysis): Light and electron microscopic studies . Acta Derm Venereol 1979;59:315-324. 10. Marshall J, Heyl T, Weber HW: Postinflammatory elastolysis and cutis laxa: A report on a new variety of this phenomenon and a discussion of some syndromes characterized by elastolysis . S Afr Med J 1966;40:1016-1022. 11. Verhagen AR, Woerdeman MJ: Post-inflammatory elastolysis and cutis laxa . Br J Dermatol 1975;92:183-190.Crossref 12. Convit J, Kerdel F, Goihman M, et al: Progressive, atrophying, chronic granulomatous dermohypodermitis: Autoimmune disease? Arch Dermatol 1973;107:271-274.Crossref 13. Ackerman AB: Histologic Diagnosis of Inflammatory Skin Diseases: A Method by Pattern Analysis . Philadelphia, Lea & Febiger, 1978, pp 483-485. 14. Reed WB, Horowitz RE, Beighton P: Acquired cutis laxa: Primary generalized elastolysis . Arch Dermatol 1971;103:661-669.Crossref 15. Hashimoto K, Kanzaki T: Cutis laxa: Ultrastructural and biochemical studies . Arch Dermatol 1975;111:861-873.Crossref 16. Uitto J: Biochemistry of the elastic fibers in normal connective tissues and its alterations in diseases . J Invest Dermatol 1979;72:1-10.Crossref 17. Byers PH, Narayanan AS, Bornstein P, et al: An X-linked form of cutis laxa due to deficiency of lysyl oxidase . Birth Defects 1976;12:293-298. 18. Vissian L, Pallies J, Woillard M, et al: Anétodermie diffuse de Pellizzari et élastases . Bull Soc Fr Dermatol Syphiligr 1974; 81:602-605. 19. Guilaine J, Recoules J, Blanchet C, et al: Anétodermie de Jadassohn avec image occeuse, abstracted . Bull Soc Fr Dermatol Syphiligr 1973;80:267-268. 20. Janoff A, Scherer J: Mediators of inflammation in leukocyte lysosomes: IX. Elastinolytic activity in granules of human polymorphonuclear leukocytes . J Exp Med 1968;128:1137-1155.Crossref 21. Baugh RJ, Travis J: Human leukocyte granule elastase: Rapid isolation and characterization . Biochemistry 1976;15:836-841.Crossref 22. Werb Z, Gordon S: Elastase secretion by stimulated macrophages: Characterization and regulation . J Exp Med 1975;142:361-377.Crossref 23. De Cremous H, Hornebeck W, Jaurand M-C, et al: Partial characterisation of an elastase-like enzyme secreted by human and monkey alveolar macrophages . J Pathol 1978;125:171-177.Crossref 24. Werb Z, Banda MJ, Jones PA: Degradation of connective tissue matrices by macrophages: I. Proteolysis of elastin, glycoproteins, and collagen by proteinases isolated from macrophages . J Exp Med 1980;152:1340-1357.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Histopathologic Findings in Anetoderma

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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1984.01650440070022
Publisher site
See Article on Publisher Site

Abstract

Abstract • We reviewed the histopathologic findings in 34 biopsy specimens from 15 patients with anetoderma. Focal loss of normal elastic fibers, necessary for the diagnosis of anetoderma, was found in all 15 cases. The persistence of fine, irregular, or twisted elastic fibers is common. A perivascular infiltrate composed of lymphocytes was found in all specimens. Plasma cells were observed in specimens from six patients, and histiocytes with some granuloma formation were found in specimens from six patients. Variations in the intensity of inflammation or in the loss of elastic tissue were not related to the clinical findings, course, or associated diseases. All anetoderma lesions appeared to have an inflammatory pathogenesis. (Arch Dermatol 1984;120:1040-1044) References 1. Jadassohn J: Ueber eine eigenartige Form von `Atrophia maculosa cutis.' Arch Dermatol Syph 1892, (suppl 1) , pp 342-358. 2. Schweninger E, Buzzi F: Multiple benign tumour-like new growths on the skin , in Unna PG, Morris M, Besner E, et al (eds): International Atlas of Rare Skin Diseasis . Hamburg, Germany, Leopold Voss, 1889-1899, vol 5, chap 15, pt (1) , plate 15, pp 4-5. 3. Deluzenne R: Les anétodermies maculeuses . Ann Dermatol Syphiligr 1956;83:618-630. 4. Korting GW, Cabré J, Holzmann H: Zur Kenntnis der Kollagenveränderungen bei der Anetodermie vom Typus Schweninger-Buzzi . Arch Klin Exp Dermatol 1964;218:274-297.Crossref 5. Cabré J: A propos du tableau histologique de l'anétodermie du type Schweninger-Buzzi , in Les maladies du tissu élastique cutané (12th Congrès de l'Association des Dermatologistes et Syphiligraphes de Langue Française, Paris, June 1965) . Paris, Masson & Cie, 1968, pp 340-343. 6. Götz H, Schuppener H-J: V. Anetodermie , in Handbuch der Haut-und Geschlechtskrankheiten . Berlin, Springer-Verlag Inc, 1969, vol 3, pt (2) , pp 480-488. 7. Venencie PY, Winkelmann RK, Moore BA: Anetoderma: Clinical findings, associations, and long-term follow-up evaluations . Arch Dermatol 1984;120:1032-1039.Crossref 8. Touraine A: Anétodermie urticarienne type Pellizzari (Sa place parmi les atrophies cutanées maculeuses) . Bull Soc Fr Dermatol Syphiligr 1941;48:602-608. 9. Nanko H, Voss Jepsen L, Zachariae H, et al: Acquired cutis laxa (generalized elastolysis): Light and electron microscopic studies . Acta Derm Venereol 1979;59:315-324. 10. Marshall J, Heyl T, Weber HW: Postinflammatory elastolysis and cutis laxa: A report on a new variety of this phenomenon and a discussion of some syndromes characterized by elastolysis . S Afr Med J 1966;40:1016-1022. 11. Verhagen AR, Woerdeman MJ: Post-inflammatory elastolysis and cutis laxa . Br J Dermatol 1975;92:183-190.Crossref 12. Convit J, Kerdel F, Goihman M, et al: Progressive, atrophying, chronic granulomatous dermohypodermitis: Autoimmune disease? Arch Dermatol 1973;107:271-274.Crossref 13. Ackerman AB: Histologic Diagnosis of Inflammatory Skin Diseases: A Method by Pattern Analysis . Philadelphia, Lea & Febiger, 1978, pp 483-485. 14. Reed WB, Horowitz RE, Beighton P: Acquired cutis laxa: Primary generalized elastolysis . Arch Dermatol 1971;103:661-669.Crossref 15. Hashimoto K, Kanzaki T: Cutis laxa: Ultrastructural and biochemical studies . Arch Dermatol 1975;111:861-873.Crossref 16. Uitto J: Biochemistry of the elastic fibers in normal connective tissues and its alterations in diseases . J Invest Dermatol 1979;72:1-10.Crossref 17. Byers PH, Narayanan AS, Bornstein P, et al: An X-linked form of cutis laxa due to deficiency of lysyl oxidase . Birth Defects 1976;12:293-298. 18. Vissian L, Pallies J, Woillard M, et al: Anétodermie diffuse de Pellizzari et élastases . Bull Soc Fr Dermatol Syphiligr 1974; 81:602-605. 19. Guilaine J, Recoules J, Blanchet C, et al: Anétodermie de Jadassohn avec image occeuse, abstracted . Bull Soc Fr Dermatol Syphiligr 1973;80:267-268. 20. Janoff A, Scherer J: Mediators of inflammation in leukocyte lysosomes: IX. Elastinolytic activity in granules of human polymorphonuclear leukocytes . J Exp Med 1968;128:1137-1155.Crossref 21. Baugh RJ, Travis J: Human leukocyte granule elastase: Rapid isolation and characterization . Biochemistry 1976;15:836-841.Crossref 22. Werb Z, Gordon S: Elastase secretion by stimulated macrophages: Characterization and regulation . J Exp Med 1975;142:361-377.Crossref 23. De Cremous H, Hornebeck W, Jaurand M-C, et al: Partial characterisation of an elastase-like enzyme secreted by human and monkey alveolar macrophages . J Pathol 1978;125:171-177.Crossref 24. Werb Z, Banda MJ, Jones PA: Degradation of connective tissue matrices by macrophages: I. Proteolysis of elastin, glycoproteins, and collagen by proteinases isolated from macrophages . J Exp Med 1980;152:1340-1357.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Aug 1, 1984

References