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Histologic Studies of Angle Structures After Laser Iridotomy in Primates

Histologic Studies of Angle Structures After Laser Iridotomy in Primates Abstract • Each of nine eyes of five cynomolgus monkeys had argon laser peripheral iridotomies performed to investigate the histologic effects on the trabecular meshwork. The laser technique was the same as is used in human eyes. With laser iridotomy, particulate debris was released into the anterior chamber and rapidly accumulated in the angle. The densest initial deposit was in the inferior juxtacanalicular trabecular meshwork. Histologically, pigment was located both extracellularly and within giant vacuoles of the endothelium and Schlemm's canal and intracellularly within trabecular endothelial cells. This finding indicates that this pigment is removed from the anterior chamber both by bulk aqueous flow and by phagocytosis. One year after iridotomy, only a slightly increased pigmentation of the angle was still present. No permanent ultrastructural damage to the angle was detected. References 1. Pollack IP: Use of argon laser energy to produce iridotomies . Trans Am Ophthalmol Soc 1979;77:674-706. 2. Pollack IP, Patz A: Argon laser iridotomy: An experimental and clinical study . Ophthalmic Surg 1976;7:22-30. 3. Podos SM, Kels BD, Moss AP, et al: Continuous wave argon laser iridectomy in angle-closure glaucoma . Am J Ophthalmol 1979;88:836-842. 4. Snyder WB, Vaiser A, Hutton WL: Laser iridectomy . Trans Am Acad Ophthalmol Otolaryngol 1975;79:381-386. 5. Anderson DR, Forster RK, Lewis ML: Laser iridotomy for aphakic pupillary block . Arch Ophthalmol 1975;93:343-346.Crossref 6. Patti JC, Cinotti AA: Iris photocoagulation therapy of aphakic pupillary block . Arch Ophthalmol 1975;93:347-348.Crossref 7. Niesnamoff E: Ueber die quantitativen Verhältnisse der Filtration und Secretion des Kammerwassers . Albrecht Von Graefes Arch Klin Exp Ophthalmol 1896;42:1-35.Crossref 8. Rodriques MM, Spaeth GL, Weinreb S, et al: Spectrum of trabecular pigmentation in open-angle glaucoma: A clinicopathologic study . Trans Am Acad Ophthalmol Otolaryngol 1976;81:258-276. 9. Kupfer C, Kuwabara T, Kaiser-Kupfer M: The histopathology of pigmentary dispersion syndrome with glaucoma . Am J Ophthalmol 1975;80:857-862. 10. Richardson TM, Hutchinson T, Grant WM: The outflow tract in pigmentary glaucoma: A light and electron microscopic study . Arch Ophthalmol 1977;95:1015-1025.Crossref 11. Fine BS, Yanoff M, Scheie HG: Pigmentary 'glaucoma': A histologic study . Trans Am Acad Ophthalmol Otolaryngol 1974;78:314-325. 12. Kampik A, Green WR, Quigley HA, et al: Scanning and transmission electron microscopic studies of two cases of pigment dispersion syndrome . Am J Ophthalmol 1981;91:573-587. 13. Van Buskirk EM, Leure-duPree AE: Patho-physiology and electron microscopy of melanomalytic glaucoma . Am J Ophthalmol 1978;85:160-166. 14. Quigley HA, Addicks EM: Chronic experimental glaucoma in primates: I. Production of elevated intraocular pressure by anterior chamber injection of autologous ghost red blood cells . Invest Ophthalmol Vis Sci 1980;19:126-136. 15. Anderson DR: Experimental alpha chymotrypsin glaucoma studied by scanning electron microscopy . Am J Ophthalmol 1971;71:470-476. 16. Grierson I, Lee WR: Erythrocyte phagocytosis in the human trabecular meshwork . Br J Ophthalmol 1973;57:400-415.Crossref 17. Shaffer RN: Discussions on Glaucoma: Proceedings of a Symposium on angle-closure glaucoma sponsored by the National Society for the Prevention of Blindness, Inc , Lichter PR, Anderson DR (eds). New York, Grune & Stratton Inc, 1977, p 110. 18. Grierson I, Chisholm IA: Clearance of debris from the iris through the drainage angle of the rabbit's eye . Br J Ophthalmol 1978;62:694-704.Crossref 19. Chisholm IA, Grierson I: Particulate phagocytosis by trabecular meshwork endothelium . Can J Ophthalmol 1977;12:293-299. 20. Fine BS: Observations on the drainage angle in man and rhesus monkey: A concept of the pathogenesis of chronic simple glaucoma: A light and electron microscopic study . Invest Ophthalmol Vis Sci 1964;3:609-646. 21. MacRae D, Sears ML: Peroxidase passage through the outflow channels of human and rhesus eyes . Exp Eye Res 1970;10:15-18.Crossref 22. Tripathi RC: Mechanism of the aqueous outflow across the trabecular wall of Schlemm's canal . Exp Eye Res 1971;11:116-121.Crossref 23. Tripathi RC: Aqueous outflow pathway in normal and glaucomatous eyes . Br J Ophthalmol 1972;56:157-174.Crossref 24. Feeney L, Wissig S: Outflow studies using an electron dense tracer . Trans Am Acad Ophthalmol Otolaryngol 1966;70:791-798. 25. Robin AL, Pollack IP: Argon laser peripheral iridotomies in the treatment of primary angle closure glaucoma. Long-term follow-up . Arch Ophthalmol , 1982;100:919-923.Crossref 26. Quigley HA: Long-term follow-up of laser iridotomy . Ophthalmology 1981;88:218-224.Crossref 27. Abraham RK, Miller GL: Outpatient argon laser iridectomies for angle-closure glaucoma: A 3½ year study . Adv Ophthalmol 1977;34:186-191. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Histologic Studies of Angle Structures After Laser Iridotomy in Primates

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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1982.01030040643018
Publisher site
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Abstract

Abstract • Each of nine eyes of five cynomolgus monkeys had argon laser peripheral iridotomies performed to investigate the histologic effects on the trabecular meshwork. The laser technique was the same as is used in human eyes. With laser iridotomy, particulate debris was released into the anterior chamber and rapidly accumulated in the angle. The densest initial deposit was in the inferior juxtacanalicular trabecular meshwork. Histologically, pigment was located both extracellularly and within giant vacuoles of the endothelium and Schlemm's canal and intracellularly within trabecular endothelial cells. This finding indicates that this pigment is removed from the anterior chamber both by bulk aqueous flow and by phagocytosis. One year after iridotomy, only a slightly increased pigmentation of the angle was still present. No permanent ultrastructural damage to the angle was detected. References 1. Pollack IP: Use of argon laser energy to produce iridotomies . Trans Am Ophthalmol Soc 1979;77:674-706. 2. Pollack IP, Patz A: Argon laser iridotomy: An experimental and clinical study . Ophthalmic Surg 1976;7:22-30. 3. Podos SM, Kels BD, Moss AP, et al: Continuous wave argon laser iridectomy in angle-closure glaucoma . Am J Ophthalmol 1979;88:836-842. 4. Snyder WB, Vaiser A, Hutton WL: Laser iridectomy . Trans Am Acad Ophthalmol Otolaryngol 1975;79:381-386. 5. Anderson DR, Forster RK, Lewis ML: Laser iridotomy for aphakic pupillary block . Arch Ophthalmol 1975;93:343-346.Crossref 6. Patti JC, Cinotti AA: Iris photocoagulation therapy of aphakic pupillary block . Arch Ophthalmol 1975;93:347-348.Crossref 7. Niesnamoff E: Ueber die quantitativen Verhältnisse der Filtration und Secretion des Kammerwassers . Albrecht Von Graefes Arch Klin Exp Ophthalmol 1896;42:1-35.Crossref 8. Rodriques MM, Spaeth GL, Weinreb S, et al: Spectrum of trabecular pigmentation in open-angle glaucoma: A clinicopathologic study . Trans Am Acad Ophthalmol Otolaryngol 1976;81:258-276. 9. Kupfer C, Kuwabara T, Kaiser-Kupfer M: The histopathology of pigmentary dispersion syndrome with glaucoma . Am J Ophthalmol 1975;80:857-862. 10. Richardson TM, Hutchinson T, Grant WM: The outflow tract in pigmentary glaucoma: A light and electron microscopic study . Arch Ophthalmol 1977;95:1015-1025.Crossref 11. Fine BS, Yanoff M, Scheie HG: Pigmentary 'glaucoma': A histologic study . Trans Am Acad Ophthalmol Otolaryngol 1974;78:314-325. 12. Kampik A, Green WR, Quigley HA, et al: Scanning and transmission electron microscopic studies of two cases of pigment dispersion syndrome . Am J Ophthalmol 1981;91:573-587. 13. Van Buskirk EM, Leure-duPree AE: Patho-physiology and electron microscopy of melanomalytic glaucoma . Am J Ophthalmol 1978;85:160-166. 14. Quigley HA, Addicks EM: Chronic experimental glaucoma in primates: I. Production of elevated intraocular pressure by anterior chamber injection of autologous ghost red blood cells . Invest Ophthalmol Vis Sci 1980;19:126-136. 15. Anderson DR: Experimental alpha chymotrypsin glaucoma studied by scanning electron microscopy . Am J Ophthalmol 1971;71:470-476. 16. Grierson I, Lee WR: Erythrocyte phagocytosis in the human trabecular meshwork . Br J Ophthalmol 1973;57:400-415.Crossref 17. Shaffer RN: Discussions on Glaucoma: Proceedings of a Symposium on angle-closure glaucoma sponsored by the National Society for the Prevention of Blindness, Inc , Lichter PR, Anderson DR (eds). New York, Grune & Stratton Inc, 1977, p 110. 18. Grierson I, Chisholm IA: Clearance of debris from the iris through the drainage angle of the rabbit's eye . Br J Ophthalmol 1978;62:694-704.Crossref 19. Chisholm IA, Grierson I: Particulate phagocytosis by trabecular meshwork endothelium . Can J Ophthalmol 1977;12:293-299. 20. Fine BS: Observations on the drainage angle in man and rhesus monkey: A concept of the pathogenesis of chronic simple glaucoma: A light and electron microscopic study . Invest Ophthalmol Vis Sci 1964;3:609-646. 21. MacRae D, Sears ML: Peroxidase passage through the outflow channels of human and rhesus eyes . Exp Eye Res 1970;10:15-18.Crossref 22. Tripathi RC: Mechanism of the aqueous outflow across the trabecular wall of Schlemm's canal . Exp Eye Res 1971;11:116-121.Crossref 23. Tripathi RC: Aqueous outflow pathway in normal and glaucomatous eyes . Br J Ophthalmol 1972;56:157-174.Crossref 24. Feeney L, Wissig S: Outflow studies using an electron dense tracer . Trans Am Acad Ophthalmol Otolaryngol 1966;70:791-798. 25. Robin AL, Pollack IP: Argon laser peripheral iridotomies in the treatment of primary angle closure glaucoma. Long-term follow-up . Arch Ophthalmol , 1982;100:919-923.Crossref 26. Quigley HA: Long-term follow-up of laser iridotomy . Ophthalmology 1981;88:218-224.Crossref 27. Abraham RK, Miller GL: Outpatient argon laser iridectomies for angle-closure glaucoma: A 3½ year study . Adv Ophthalmol 1977;34:186-191.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Oct 1, 1982

References