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Histologic Changes in Clinically Normal Breasts at Postmortem Examination

Histologic Changes in Clinically Normal Breasts at Postmortem Examination Abstract IN A PREVIOUS publication1 we reported that severe epithelial hyperplasia of the large ducts was found in 69% of breasts removed for carcinoma and in only 16% of breast tissue diagnosed as "fibrocystic disease." Having defined and used our own criteria for the micropathological characterization of benign breast changes associated with carcinoma of the breast and "fibrocystic disease" of the breast, it became necessary to ascertain the frequency of these changes in clinically normal breasts. This study was undertaken to determine the breast changes in 100 consecutive autopsies of women 20 years of age and older with clinically normal breasts. Methods and Results This histologic study, as our previous study, evaluated severe epithelial hyperplasia of the large ducts, the small ducts, and the acini. The presence or absence of fibrosis, sclerosing adenosis, papillomas, apocrine changes, and cysts was noted. The detailed criteria for microscopic changes was described in a References 1. Humphrey, L.J., and Swerdlow, M.: Relationship of Benign Breast Disease to Carcinoma of the Breast , Surgery 52:84, 1962. 2. Lindgren, S.: On Mastopathia Cystica: Its Frequency at Post Mortem Examinations and the Possibility of Its Spontaneous Regression , Acta Clin Scand 79:119, 1936-1937. 3. Swerdlow, M., and Humphrey, L.J.: Fibro-cystic Disease and Carcinoma of the Breast , Arch Surg 87:457, 1963.Crossref 4. Sloss, P.T.; Bennett, W.A.; and Clagett, O.T.: Incidence in Normal Breasts of Features Associated With Chronic Cystic Mastitis , Amer J Path 33:1181, 1957. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Histologic Changes in Clinically Normal Breasts at Postmortem Examination

Archives of Surgery , Volume 92 (2) – Feb 1, 1966

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Publisher
American Medical Association
Copyright
Copyright © 1966 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1966.01320200032005
Publisher site
See Article on Publisher Site

Abstract

Abstract IN A PREVIOUS publication1 we reported that severe epithelial hyperplasia of the large ducts was found in 69% of breasts removed for carcinoma and in only 16% of breast tissue diagnosed as "fibrocystic disease." Having defined and used our own criteria for the micropathological characterization of benign breast changes associated with carcinoma of the breast and "fibrocystic disease" of the breast, it became necessary to ascertain the frequency of these changes in clinically normal breasts. This study was undertaken to determine the breast changes in 100 consecutive autopsies of women 20 years of age and older with clinically normal breasts. Methods and Results This histologic study, as our previous study, evaluated severe epithelial hyperplasia of the large ducts, the small ducts, and the acini. The presence or absence of fibrosis, sclerosing adenosis, papillomas, apocrine changes, and cysts was noted. The detailed criteria for microscopic changes was described in a References 1. Humphrey, L.J., and Swerdlow, M.: Relationship of Benign Breast Disease to Carcinoma of the Breast , Surgery 52:84, 1962. 2. Lindgren, S.: On Mastopathia Cystica: Its Frequency at Post Mortem Examinations and the Possibility of Its Spontaneous Regression , Acta Clin Scand 79:119, 1936-1937. 3. Swerdlow, M., and Humphrey, L.J.: Fibro-cystic Disease and Carcinoma of the Breast , Arch Surg 87:457, 1963.Crossref 4. Sloss, P.T.; Bennett, W.A.; and Clagett, O.T.: Incidence in Normal Breasts of Features Associated With Chronic Cystic Mastitis , Amer J Path 33:1181, 1957.

Journal

Archives of SurgeryAmerican Medical Association

Published: Feb 1, 1966

References