Abstract Groups of albino guinea pigs were exposed to high concentrations of oxygen at several pressures and the eyes of the animals examined for histological changes both immediately and several months following the exposures. Normal animals as well as animals exposed to conditions of anoxia and hyperbaria were also examined. Ocular changes were observed only in the animals exposed to 100% oxygen at 3 and 5 atmospheres absolute. The primary alterations, which were found to be irreversible over the time of observation, included thinning of the corneal endothelium with darkening and condensation of the cytoplasm and pyknosis of the nuclei, and pyknosis and loss of nuclei from the epithelium of the lens. References 1. Lambertsen CJ: Effects of oxygen at high partial pressure , in Fenn WO, Rahn H (eds): Handbook of Physiology. Washington , American Physiology Society, 1964, pp 1027-1046. 2. Beehler CC, Newton NL, Culver JF, et al: Ocular hyperoxia . Aerospace Med 34:1017-1020, 1963. 3. Margolis G, Brown IW Jr: Hyperbaric oxygenation: The eye as a limiting factor . Science 151:466-468, 1966.Crossref 4. Noell WK: Effects of high and low oxygen tension on the visual system , in Schaefer KE (ed): Effects of Environment on Consciousness . New York, MacMillan Co, 1962, pp 3-18. 5. Bridges WZ: Electroretinographic manifestations of hyperbaric oxygen . Arch Ophthal 75:812-817, 1966.Crossref 6. Behnke AR, Forbes HS, Motley EP: Circulatory and visual effects of oxygen at 3 atmospheres pressure . Amer J Physiol 114:436-442, 1936. 7. Gallagher TJ, Mammen RE, Nobrega FT, et al: The Effects of Various Oxygen Partial Pressures on Scotopic and Photopic Vision. United States Naval Aerospace Crew Equipment Laboratory (NAEC-ACEL-530), 1963. 8. Yanoff M, Zimmerman LF, Fine BS: Glutaraldehyde fixation of whole eyes . Amer J Clin Path 44:167-171, 1965. 9. Yanoff M, Fine BS: Glutaraldehyde fixation of routine surgical eye tissue . Amer J Ophthal 63:137-140, 1967. 10. Dollery CT, Hill DW, Mailer CM, et al: High oxygen pressure and the retinal blood-vessels . Lancet 2:291-292, 1964.Crossref 11. Nichols CW, Lambertsen CJ: Effects of high oxygen pressures on the eye . New Eng J Med 281:25-30, 1969.Crossref 12. Nichols CW, Lambertsen CJ, Clark JM: Transient unilateral loss of vision associated with oxygen at high pressure . Arch Ophthal 81:548-552, 1969.Crossref
Archives of Ophthalmology – American Medical Association
Published: Apr 1, 1972
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