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Histogenesis of Basal-Cell Carcinoma

Histogenesis of Basal-Cell Carcinoma Abstract Introduction Basal-cell carcinoma has interested scores of investigators because it is seemingly a biologic enigma. It appears that a tumor derived supposedly from the more primitive epidermal basal cell is biologically less active or malignant than a tumor derived from the maturer "child" of the basal germinative cell, the prickle cell. This situation appears unique in the skin: Tumors of squamous epithelial mucous membranes, such as the cervix of the uterus, gingiva, buccal mucosa, esophagus, and the like, also apparently of basal-cell origin, follow the rules, and are more malignant than tumors presumably of the maturer prickle cell. The purpose of this report is to clarify and enlarge upon our previously expressed attitude (Smith and Swerdlow), namely, that basal-cell tumors arise from hair anlage. It is my feeling now and the thesis of this report that basal-cell carcinoma is less malignant than prickle-cell carcinoma because it represents an abortive References 1. Adamson, H. G.: On the Nature of Rodent Ulcer: Its Relationship to Epithelioma Adenoides Cysticum of Brooke and to Other Trichoepitheliomata of Benign Nevoid Character; Its Distinction from Malignant Carcinoma , Lancet 1:810, 1914.Crossref 2. Arey, L. B.: Developmental Anatomy , Ed. 5, Philadelphia, W. B. Saunders Company, 1946. 3. Allen, A. C.: The Skin: A Clinicopathologic Treatise , St. Louis, The C. V. Mosby Company, 1954. 4. Baker, B. L.: The Relationship of the Adrenal, Thyroid, and Pituitary Glands to the Growth of Hair , Ann. New York Acad. Sc. 53:690, 1951.Crossref 5. Bissel, G. W.: Hirsutism , Ann. New York Acad. Sc. 53:742, 1951.Crossref 6. Butcher, E. O.: Development of the Pilary System and the Replacement of Hair in Mammals , Ann. New York Acad. Sc. 53:508, 1951.Crossref 7. Cervantes, Ochoa P.; Smith, O. D., and Swerdlow, M.: The Dermal-Epidermal Junction: A Preliminary Study with Periodic Acid-Schiff Stain , A. M. A. Arch. Dermat. 75:70, 1957.Crossref 8. Dubreuilh, W., and Auché, B.: De l'Ulcus rodens: Clinique et anatomie pathologique , Ann. dermat. et syph. 2:705, 1901. 9. Eichenlaub, F. J., and Osbourn, R. A.: Studies in the Histogenesis of the Epidermis , A. M. A. Arch. Dermat. & Syph. 64:700, 1951. 10. Ewing, J.: Neoplastic Diseases , Ed. 3, Philadelphia, W. B. Saunders Company, 1928. 11. Foot, N. C.: Adnexal Carcinoma of the Skin , Am. J. Path. 23:1, 1947. 12. Foot, N. C.: The Role of the Piliary System in Cancer of the Skin , Ann. New York Acad. Sc. 53:749, 1951. 13. Goldman, H. J.: Multiple Benign Cystic Epithelioma: Report of Ten Cases in One Family , J. A. M. A. 115:2253, 1940. 14. Haythorn, S. R.: Studies on the Histogenesis of the So-Called "Basal-Cell Carcinoma," Am. J. Cancer ( (Supp.) ) 15:1969, 1931. 15. Kukita, A., and Fitzpatrick, T. B.: Demonstration of Tyrosinase in Melanocytes of the Human Hair Matrix by Autoradiography , Science 121:893, 1955. 16. Krompecher, E.: Der Basalzellenkrebs , Jena, VEB Gustav Fischer Verlag, 1903. 17. Krompecher, E.: Der drüsenartige Oberflächenepithelkrebs , Beitr. path. Anat. 28:1, 1900. 18. Kyrle, J.: Beitrag zur Frage der Basalzellengeschwülste der Haut , Arch. Dermat. u. Syph. 121:246, 1915. 19. Lattes, R., and Kessler, R. W.: Metastasizing Basal-Cell Epithelioma of the Skin , Cancer 4:866, 1951. 20. Lever, W. F.: Pathogenesis of Benign Tumors of Cutaneous Appendages and of Basal Cell Epithelioma: II. Basal Cell Epithelioma [W. F. Lever] , Arch. Dermat. & Syph. 57:709, 1948. 21. Lever, W. F.: Histopathology of the Skin , Ed. 2, Philadelphia, J. B. Lippincott Company, 1954. 22. Liebow, A. A.; Warren, S., and DeCoursey, E.: Pathology of Atom Bomb Casualties , Am. J. Path. 25:853, 1949. 23. Liebow, A. A.: Effects Produced on Hair by Atomic Bombs , Ann. New York Acad. Sc. 53:688, 1951. 24. Mac Cardle, R. C.: Histology and Cytology of the Skin, Course in Pathologic Physiology and Pathology of the Skin , presented at International Academy of Pathology , Washington, D. C., (April 8) -10, 1957. 25. Mallory, F. B.: Recent Progress in the Microscopic Anatomy and Differentiation of Cancer , J. A. M. A. 55:1513, 1910. 26. Medewar, P. B.: The Behaviour and Fate of Skin Autografts and Skin Homografts in Rabbits (Report to War Wounds Committee of Medical Research Council) , J. Anat. 78:176, 1944. 27. Montagna, W.: The Structure and Function of Skin , New York, Academic Press, Inc., 1956. 28. Montgomery, H.: Histogenesis of Basal-Cell Epithelioma , Radiology 25:8, 1935.Crossref 29. Oettle, A. G.: Rodent Ulcers in Identical Twins , A. M. A. Arch. Dermat. 74:167, 1956.Crossref 30. Pinkus, H.: Multiple Hairs ( Flemming-Giovannini): Report of 2 Cases of Pili Multi-gemini and Discussion of Some Other Anomalies of the Piliary Complex , J. Invest. Dermat. 17: 291, 1951.Crossref 31. Pinkus, H.: Examination of the Epidermis by the Strip Method of Removing Horny Layers: Observations on Thickness of the Horny Layer, and on Mitotic Activity After Stripping , J. Invest. Dermat. 16:383, 1951. 32. Pinkus, H.: Examination of the Epidermis by the Strip Method of Removing Horny Layers: Biometric Data on Regeneration of the Human Epidermis , J. Invest. Dermat. 19:431, 1952.Crossref 33. Pinkus, H.: Premalignant Fibroepithelial Tumors of Skin , A. M. A. Arch. Dermat. & Syph. 67:598, 1953. 34. Pinkus, F.: The Story of a Hair Root , J. Invest. Dermat. 9:91, 1947. 35. Planner, H.: Beitrag zur Frage der Neubildungsmöglichkeit der Hautdrüsen , Arch. Dermat. u. Syph. 146:28, 1923. 36. Ribbert, H.: Über Neubildung von Talgdrüsen , Arch. Entwcklngsmechn. Organ. 18:578, 1904. 37. Silberberg, M., and Silberberg, R.: Hair Growth in the Skin of Guinea Pigs Painted with 20-Methylcholanthrene , Arch. Path. 44:297, 1947. 38. Smith, O. D., and Swerdlow, M. A.: Histogenesis of Basal-Cell Epithelioma , A. M. A. Arch. Dermat. 74:286, 1956. 39. Taylor, A. C.: Survival of Rat Skin and Changes in Hair Pigmentation Following Freezing , J. Exper. Zool. 110:77, 1949. 40. Teloh, H. A., and Wheelock, M. C.: Histogenesis of Basal Cell Carcinoma , Arch. Path. 48: 447, 1949. 41. Thigpen, L. W.: Growth, Replacement and Types of Hair: Inheritance—Distribution, Pattern, Quality, and Quantity , Ann. New York Acad. Sc. 53:674, 1951. 42. Toolan, H. W.: Proliferation and Vascularization of Adult Human Epithelium in Subcutaneous Tissues of X-Irradiated Heterologous Hosts , Proc. Soc. Exper. Biol. & Med. 78:540, 1951. 43. Wallace, S. A., and Halpert, B.: Trichoma: Tumor of Hair Anlage , Arch. Path. 50:199, 1950. 44. Welton, D. G.; Elliott, J. A., and Kimmelstiel, P.: Epithelioma: Clinical and Histologic Data on 1,925 lesions , Arch. Dermat. & Syph. 60: 277, 1949. 45. Willis, R. A.: Pathology of Tumours , Ed. 2, St. Louis, The C. V. Mosby Company, 1953. 46. Wolbach, S. B.: The Hair Cycle of the Mouse and Its Importance in the Study of Sequences of Experimental Carcinogenesis , Ann. New York Acad. Sc. 53:517, 1951. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Histogenesis of Basal-Cell Carcinoma

A.M.A. Archives of Dermatology , Volume 78 (5) – Nov 1, 1958

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American Medical Association
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Copyright © 1958 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1958.01560110011002
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Abstract

Abstract Introduction Basal-cell carcinoma has interested scores of investigators because it is seemingly a biologic enigma. It appears that a tumor derived supposedly from the more primitive epidermal basal cell is biologically less active or malignant than a tumor derived from the maturer "child" of the basal germinative cell, the prickle cell. This situation appears unique in the skin: Tumors of squamous epithelial mucous membranes, such as the cervix of the uterus, gingiva, buccal mucosa, esophagus, and the like, also apparently of basal-cell origin, follow the rules, and are more malignant than tumors presumably of the maturer prickle cell. The purpose of this report is to clarify and enlarge upon our previously expressed attitude (Smith and Swerdlow), namely, that basal-cell tumors arise from hair anlage. It is my feeling now and the thesis of this report that basal-cell carcinoma is less malignant than prickle-cell carcinoma because it represents an abortive References 1. Adamson, H. G.: On the Nature of Rodent Ulcer: Its Relationship to Epithelioma Adenoides Cysticum of Brooke and to Other Trichoepitheliomata of Benign Nevoid Character; Its Distinction from Malignant Carcinoma , Lancet 1:810, 1914.Crossref 2. Arey, L. B.: Developmental Anatomy , Ed. 5, Philadelphia, W. B. Saunders Company, 1946. 3. Allen, A. C.: The Skin: A Clinicopathologic Treatise , St. Louis, The C. V. Mosby Company, 1954. 4. Baker, B. L.: The Relationship of the Adrenal, Thyroid, and Pituitary Glands to the Growth of Hair , Ann. New York Acad. Sc. 53:690, 1951.Crossref 5. Bissel, G. W.: Hirsutism , Ann. New York Acad. Sc. 53:742, 1951.Crossref 6. Butcher, E. O.: Development of the Pilary System and the Replacement of Hair in Mammals , Ann. New York Acad. Sc. 53:508, 1951.Crossref 7. Cervantes, Ochoa P.; Smith, O. D., and Swerdlow, M.: The Dermal-Epidermal Junction: A Preliminary Study with Periodic Acid-Schiff Stain , A. M. A. Arch. Dermat. 75:70, 1957.Crossref 8. Dubreuilh, W., and Auché, B.: De l'Ulcus rodens: Clinique et anatomie pathologique , Ann. dermat. et syph. 2:705, 1901. 9. Eichenlaub, F. J., and Osbourn, R. A.: Studies in the Histogenesis of the Epidermis , A. M. A. Arch. Dermat. & Syph. 64:700, 1951. 10. Ewing, J.: Neoplastic Diseases , Ed. 3, Philadelphia, W. B. Saunders Company, 1928. 11. Foot, N. C.: Adnexal Carcinoma of the Skin , Am. J. Path. 23:1, 1947. 12. Foot, N. C.: The Role of the Piliary System in Cancer of the Skin , Ann. New York Acad. Sc. 53:749, 1951. 13. Goldman, H. J.: Multiple Benign Cystic Epithelioma: Report of Ten Cases in One Family , J. A. M. A. 115:2253, 1940. 14. Haythorn, S. R.: Studies on the Histogenesis of the So-Called "Basal-Cell Carcinoma," Am. J. Cancer ( (Supp.) ) 15:1969, 1931. 15. Kukita, A., and Fitzpatrick, T. B.: Demonstration of Tyrosinase in Melanocytes of the Human Hair Matrix by Autoradiography , Science 121:893, 1955. 16. Krompecher, E.: Der Basalzellenkrebs , Jena, VEB Gustav Fischer Verlag, 1903. 17. Krompecher, E.: Der drüsenartige Oberflächenepithelkrebs , Beitr. path. Anat. 28:1, 1900. 18. Kyrle, J.: Beitrag zur Frage der Basalzellengeschwülste der Haut , Arch. Dermat. u. Syph. 121:246, 1915. 19. Lattes, R., and Kessler, R. W.: Metastasizing Basal-Cell Epithelioma of the Skin , Cancer 4:866, 1951. 20. Lever, W. F.: Pathogenesis of Benign Tumors of Cutaneous Appendages and of Basal Cell Epithelioma: II. Basal Cell Epithelioma [W. F. Lever] , Arch. Dermat. & Syph. 57:709, 1948. 21. Lever, W. F.: Histopathology of the Skin , Ed. 2, Philadelphia, J. B. Lippincott Company, 1954. 22. Liebow, A. A.; Warren, S., and DeCoursey, E.: Pathology of Atom Bomb Casualties , Am. J. Path. 25:853, 1949. 23. Liebow, A. A.: Effects Produced on Hair by Atomic Bombs , Ann. New York Acad. Sc. 53:688, 1951. 24. Mac Cardle, R. C.: Histology and Cytology of the Skin, Course in Pathologic Physiology and Pathology of the Skin , presented at International Academy of Pathology , Washington, D. C., (April 8) -10, 1957. 25. Mallory, F. B.: Recent Progress in the Microscopic Anatomy and Differentiation of Cancer , J. A. M. A. 55:1513, 1910. 26. Medewar, P. B.: The Behaviour and Fate of Skin Autografts and Skin Homografts in Rabbits (Report to War Wounds Committee of Medical Research Council) , J. Anat. 78:176, 1944. 27. Montagna, W.: The Structure and Function of Skin , New York, Academic Press, Inc., 1956. 28. Montgomery, H.: Histogenesis of Basal-Cell Epithelioma , Radiology 25:8, 1935.Crossref 29. Oettle, A. G.: Rodent Ulcers in Identical Twins , A. M. A. Arch. Dermat. 74:167, 1956.Crossref 30. Pinkus, H.: Multiple Hairs ( Flemming-Giovannini): Report of 2 Cases of Pili Multi-gemini and Discussion of Some Other Anomalies of the Piliary Complex , J. Invest. Dermat. 17: 291, 1951.Crossref 31. Pinkus, H.: Examination of the Epidermis by the Strip Method of Removing Horny Layers: Observations on Thickness of the Horny Layer, and on Mitotic Activity After Stripping , J. Invest. Dermat. 16:383, 1951. 32. Pinkus, H.: Examination of the Epidermis by the Strip Method of Removing Horny Layers: Biometric Data on Regeneration of the Human Epidermis , J. Invest. Dermat. 19:431, 1952.Crossref 33. Pinkus, H.: Premalignant Fibroepithelial Tumors of Skin , A. M. A. Arch. Dermat. & Syph. 67:598, 1953. 34. Pinkus, F.: The Story of a Hair Root , J. Invest. Dermat. 9:91, 1947. 35. Planner, H.: Beitrag zur Frage der Neubildungsmöglichkeit der Hautdrüsen , Arch. Dermat. u. Syph. 146:28, 1923. 36. Ribbert, H.: Über Neubildung von Talgdrüsen , Arch. Entwcklngsmechn. Organ. 18:578, 1904. 37. Silberberg, M., and Silberberg, R.: Hair Growth in the Skin of Guinea Pigs Painted with 20-Methylcholanthrene , Arch. Path. 44:297, 1947. 38. Smith, O. D., and Swerdlow, M. A.: Histogenesis of Basal-Cell Epithelioma , A. M. A. Arch. Dermat. 74:286, 1956. 39. Taylor, A. C.: Survival of Rat Skin and Changes in Hair Pigmentation Following Freezing , J. Exper. Zool. 110:77, 1949. 40. Teloh, H. A., and Wheelock, M. C.: Histogenesis of Basal Cell Carcinoma , Arch. Path. 48: 447, 1949. 41. Thigpen, L. W.: Growth, Replacement and Types of Hair: Inheritance—Distribution, Pattern, Quality, and Quantity , Ann. New York Acad. Sc. 53:674, 1951. 42. Toolan, H. W.: Proliferation and Vascularization of Adult Human Epithelium in Subcutaneous Tissues of X-Irradiated Heterologous Hosts , Proc. Soc. Exper. Biol. & Med. 78:540, 1951. 43. Wallace, S. A., and Halpert, B.: Trichoma: Tumor of Hair Anlage , Arch. Path. 50:199, 1950. 44. Welton, D. G.; Elliott, J. A., and Kimmelstiel, P.: Epithelioma: Clinical and Histologic Data on 1,925 lesions , Arch. Dermat. & Syph. 60: 277, 1949. 45. Willis, R. A.: Pathology of Tumours , Ed. 2, St. Louis, The C. V. Mosby Company, 1953. 46. Wolbach, S. B.: The Hair Cycle of the Mouse and Its Importance in the Study of Sequences of Experimental Carcinogenesis , Ann. New York Acad. Sc. 53:517, 1951.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Nov 1, 1958

References