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Histamine Levels in Human Skin

Histamine Levels in Human Skin Abstract A review of the literature and the experiments reported in this paper demonstrate that two most important factors must be considered in any estimation of a "normal" skin histamine level, namely, (1) the region from which the skin was taken, and (2) the method of tissue extraction used. 1. Region from Which Skin Was Taken Feldberg and Miles1 demonstrated a striking regional variation in skin histamine levels in the guinea pig, and this finding has been confirmed.2 It was, therefore, considered most likely that a similar variation might occur in humans, though a review of the literature failed to reveal any significant information on this point. The present study is of skin histamine levels in 13 cases of traumatic sudden death: 12 by automobile accidents, and 1 a traumatic air embolism. All derminations were run within 24 hours of death (from prior guinea pig experiments, References 1. Feldberg, W., and Miles, A. A.: Regional Variations of Increased Permeability of Skin Capillaries Induced by a Histamine Liberator and Their Relation to the Histamine Content of the Skin . J. Physiol. 120:205-213, 1953. 2. Johnson, H. H., Jr.: Variations in Histamine Levels in Guinea Pig Skin Related to Skin Region; Age (or Weight); and Time after Death of the Animal , J. Invest. Dermat. 27:159-163, 1956.Crossref 3. Lowry, O. H.; Graham, H. T.; Harris, F. B.; Priebat, M. K.; Marks, A. R., and Bergman, R. A.: The Chemical Measurement of Histamine in Blood Plasma and Cells , J. Pharmacol. & Exper. Therap. 112:116-126, 1954. 4. Halpern, B. N.; Biozzi, G.; Briol, M., and Benacerraf, B.: Modalités de la recharge des tissus en histamine après sa depletion par une substance libératrice d'histamine et action empêchante de la cortisone sur cette recharge , Compt. rend. Soc. biol. 147:1180-1184, 1953. 5. Johnson, H. H., Jr.: A Microchemical Method for the Determination of Histamine: Its Application to Skin Biopsies , A. M. A. Arch. Dermat. 72:307-312, 1955. 6. Harris, K. E.: Observations upon a Histamine-like Substance in Skin Extracts , Heart 14:161-175, 1927. 7. Feldberg, W., and Loesser, A. A.: The Histamine Content of Human Skin in Different Clinical Disorders , J. Physiol. 126:286-292, 1954. 8. Gate, J.; Pellerat, J.; Badal, M., and Murat, M.: Recherches sur l'histaminémie en dermatologie et le taux physiologique de l'histamine cutanée , Compt. rend. Soc. biol. 138:542-544, 1944. 9. Pellerat, M. J., and Murat, M.: L'Histamine cutanée , Ann. Dermat. et Syph. 6:76-84, 1946. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Histamine Levels in Human Skin

A.M.A. Archives of Dermatology , Volume 76 (6) – Dec 1, 1957

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Publisher
American Medical Association
Copyright
Copyright © 1957 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1957.01550240044008
Publisher site
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Abstract

Abstract A review of the literature and the experiments reported in this paper demonstrate that two most important factors must be considered in any estimation of a "normal" skin histamine level, namely, (1) the region from which the skin was taken, and (2) the method of tissue extraction used. 1. Region from Which Skin Was Taken Feldberg and Miles1 demonstrated a striking regional variation in skin histamine levels in the guinea pig, and this finding has been confirmed.2 It was, therefore, considered most likely that a similar variation might occur in humans, though a review of the literature failed to reveal any significant information on this point. The present study is of skin histamine levels in 13 cases of traumatic sudden death: 12 by automobile accidents, and 1 a traumatic air embolism. All derminations were run within 24 hours of death (from prior guinea pig experiments, References 1. Feldberg, W., and Miles, A. A.: Regional Variations of Increased Permeability of Skin Capillaries Induced by a Histamine Liberator and Their Relation to the Histamine Content of the Skin . J. Physiol. 120:205-213, 1953. 2. Johnson, H. H., Jr.: Variations in Histamine Levels in Guinea Pig Skin Related to Skin Region; Age (or Weight); and Time after Death of the Animal , J. Invest. Dermat. 27:159-163, 1956.Crossref 3. Lowry, O. H.; Graham, H. T.; Harris, F. B.; Priebat, M. K.; Marks, A. R., and Bergman, R. A.: The Chemical Measurement of Histamine in Blood Plasma and Cells , J. Pharmacol. & Exper. Therap. 112:116-126, 1954. 4. Halpern, B. N.; Biozzi, G.; Briol, M., and Benacerraf, B.: Modalités de la recharge des tissus en histamine après sa depletion par une substance libératrice d'histamine et action empêchante de la cortisone sur cette recharge , Compt. rend. Soc. biol. 147:1180-1184, 1953. 5. Johnson, H. H., Jr.: A Microchemical Method for the Determination of Histamine: Its Application to Skin Biopsies , A. M. A. Arch. Dermat. 72:307-312, 1955. 6. Harris, K. E.: Observations upon a Histamine-like Substance in Skin Extracts , Heart 14:161-175, 1927. 7. Feldberg, W., and Loesser, A. A.: The Histamine Content of Human Skin in Different Clinical Disorders , J. Physiol. 126:286-292, 1954. 8. Gate, J.; Pellerat, J.; Badal, M., and Murat, M.: Recherches sur l'histaminémie en dermatologie et le taux physiologique de l'histamine cutanée , Compt. rend. Soc. biol. 138:542-544, 1944. 9. Pellerat, M. J., and Murat, M.: L'Histamine cutanée , Ann. Dermat. et Syph. 6:76-84, 1946.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Dec 1, 1957

References