Abstract To the Editor. —Measurement of epithelial thickness and accurate location of corneal pathologic conditions have relied on slit-lamp examination and optical pachymetry.1 Recent advances in ultrasound transducer technology have enabled ultrasound pulses of shorter duration and higher frequency (10 to 100 MHz) to be produced. High-frequency ultrasound has been used to study the angle of the anterior chamber, but the resolution is sufficient to suggest a role for ultrasound in analysis of corneal diseases.2We used a high-frequency ultrasound scanning system that acquires serial parallel scans through a water-bath coupling medium.3 The ultrasound data were digitized and computationally enhanced to provide optimal estimates of interface locations using digital signal-processing techniques (the deconvolved analytic signal magnitude [DAS] of the echo data).3 This provided improved precision vis-à-vis conventional analog peak detection (A-scan).4A normal human corneal scan (Fig 1, top) shows the epithelial-stromal acoustic interface superficially at References 1. Stark WJ, Gilbert ML, Gottsch JD, Munnerlyn C. Optical pachometry in the measurement of anterior corneal disease: an evaluative tool for phototherapeutic keratectomy . Arch Ophthalmol . 1990;108:12-13.Crossref 2. Pavlin CJ, Michael DS, Foster FS. Subsurface ultrasound microscopic imaging of the intact eye . Ophthalmology . 1990;97:224-250.Crossref 3. Coleman DJ, Silverman RH, Woods SM, Rondeau MJ. Advances in ophthalmic ultrasound. In: Haik B, Mafee M, eds. Advanced Ophthalmic Imaging. Boston, Mass: Little Brown & Co Inc. In press. 4. Gammell PM. Improved ultrasonic detection using analytic signal magnitude . Ultrasonics . 1981;19:73-76.Crossref
Archives of Ophthalmology – American Medical Association
Published: Apr 1, 1993
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera