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High-Flow Oxygen for Treatment of Cluster Headache

High-Flow Oxygen for Treatment of Cluster Headache ORIGINAL CONTRIBUTION High-Flow Oxygen for Treatment of Cluster Headache A Randomized Trial Anna S. Cohen, PhD, MRCP Context Cluster headache is an excruciatingly painful primary headache syndrome, Brian Burns, MD, MRCP with attacks of unilateral pain and cranial autonomic symptoms. The current licensed treatment for acute attacks is subcutaneous sumatriptan. Peter J. Goadsby, MD, PhD, DSc, FRACP, FRCP Objective To ascertain whether high-flow inhaled oxygen was superior to placebo in the acute treatment of cluster headache. LUSTER HEADACHE IS A STEREO- Design, Setting, and Patients A double-blind, randomized, placebo-controlled typical primary headache syn- crossover trial of 109 adults (aged 18-70 years) with cluster headache as defined by drome characterized by at- the International Headache Society. Patients treated 4 headache episodes with high- Ctacks of unilateral excruciating flow inhaled oxygen or placebo, alternately. Patients were randomized to the order in pain usually in the eye, periorbital re- which they received the active treatment or placebo. Patients were recruited and fol- gion, and temple with associated cra- lowed up between 2002 and 2007 at the National Hospital for Neurology and Neu- rosurgery, London, England. nial autonomic symptoms such as con- junctival injection, lacrimation, nasal Intervention Inhaled oxygen at 100%, 12 L/min, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

High-Flow Oxygen for Treatment of Cluster Headache

JAMA , Volume 302 (22) – Dec 9, 2009

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Publisher
American Medical Association
Copyright
Copyright 2009 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2009.1855
pmid
19996400
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION High-Flow Oxygen for Treatment of Cluster Headache A Randomized Trial Anna S. Cohen, PhD, MRCP Context Cluster headache is an excruciatingly painful primary headache syndrome, Brian Burns, MD, MRCP with attacks of unilateral pain and cranial autonomic symptoms. The current licensed treatment for acute attacks is subcutaneous sumatriptan. Peter J. Goadsby, MD, PhD, DSc, FRACP, FRCP Objective To ascertain whether high-flow inhaled oxygen was superior to placebo in the acute treatment of cluster headache. LUSTER HEADACHE IS A STEREO- Design, Setting, and Patients A double-blind, randomized, placebo-controlled typical primary headache syn- crossover trial of 109 adults (aged 18-70 years) with cluster headache as defined by drome characterized by at- the International Headache Society. Patients treated 4 headache episodes with high- Ctacks of unilateral excruciating flow inhaled oxygen or placebo, alternately. Patients were randomized to the order in pain usually in the eye, periorbital re- which they received the active treatment or placebo. Patients were recruited and fol- gion, and temple with associated cra- lowed up between 2002 and 2007 at the National Hospital for Neurology and Neu- rosurgery, London, England. nial autonomic symptoms such as con- junctival injection, lacrimation, nasal Intervention Inhaled oxygen at 100%, 12 L/min,

Journal

JAMAAmerican Medical Association

Published: Dec 9, 2009

References