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Hexachlorophene Toxicity in an Infant

Hexachlorophene Toxicity in an Infant Abstract SINCE the introduction of hexachlorophene in 1948,1 it has been in increasingly wide use for topical purposes because of its relatively low toxicity and highly bactericidal properties. It has been mainly incorporated in antiseptic detergents but it is now common in baby powders, aftershave lotions, germicidal soaps, deodorants, and even tooth-paste.2 With the ever increasing availability of this agent, toxicity from accidental ingestion has become a lurking danger. Several cases of toxicity both in children and adults due to accidental ingestion of hexachlorophene are now known, two with fatal outcome, one in an infant and one in an older child. This report was prompted by the fact that the course of prolonged accidental ingestion of hexachlorophene in an infant, with survival, has not as yet been encountered in the literature. Report of Case A male infant was delivered to a gravida 4, Para 2, white mother after an References 1. New and Nonofficial Drugs , Philadelphia: J. B. Lippincott Co., 1964. 2. Hexachlorophene Toxicity , National Clearing House for Poison Control Centers ( (Sept) -Oct) 1962. 3. Oster, K., and Giarman, N.J.: " Chemotherapy of Bacterial Infections: 1. Antiseptics and Germicides ," in DiPalma, J. R. (ed.): Drill's Pharmacology in Medicine , ed 3, New York: McGraw-Hill Book Co., Inc., 1965. 4. Beckman, H.: Pharmacology: The Nature, Action, and Use of Drugs , ed 2, Philadelphia: W. B. Saunders Co., 1961. 5. Chung, H.L., et al: Hexachlorophene (G-11) as a New Specific Drug Against Clonorchiasis Sinensis: Its Efficacy and Toxicity in Experimental and Human Infection , Chin Med J 82: 691, 1963. 6. Florestano, H.J.: Tuberculocidal Activity and Toxicity of Some Diphenylmethane Derivatives , J Pharmacol Exp Ther 96:238, 1949. 7. Wear, J.B., Jr.; Shanahan, R.; and Ratliff, R.K.: Toxicity of Ingested Hexachlorophene , JAMA 181:587, 1962.Crossref 8. Lustig, F.W.: A Fatal Case of Hexachlorophene (pHisoHex) Poisoning , Med J Aust 1:737, 1963. 9. Communication to author from Winthrop Laboratories, March, 1965. 10. Dreisbach, R.H.: Handbook of Poisoning , Los Altos, Calif.: Lange Medical Publications, 1963 11. pHisoHex: An Appraisal After 15 Years of Clinical Use, Winthrop Laboratories, 1963. 12. Wit, J.G., and van Genderen, H.: Some Aspects of the Fate of Hexachlorophene (2.2' Methylene Bis 3.4.6 Trichlorophenol) in Rabbits, Rats, and Dairy Cattle , Acta Physiol Pharmacol Neerl 11:123, 1962. 13. Herter, W.B.: Hexachlorophene Poisoning , Kaiser Foundation Medical Bulletin 7:228, 1959. 14. von Oettingen, W.F.: Poisoning: A Guide to Clinical Diagnosis and Treatment , Philadelphia: W. B. Saunders Co., 1958. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Hexachlorophene Toxicity in an Infant

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Publisher
American Medical Association
Copyright
Copyright © 1966 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1966.02090060143023
Publisher site
See Article on Publisher Site

Abstract

Abstract SINCE the introduction of hexachlorophene in 1948,1 it has been in increasingly wide use for topical purposes because of its relatively low toxicity and highly bactericidal properties. It has been mainly incorporated in antiseptic detergents but it is now common in baby powders, aftershave lotions, germicidal soaps, deodorants, and even tooth-paste.2 With the ever increasing availability of this agent, toxicity from accidental ingestion has become a lurking danger. Several cases of toxicity both in children and adults due to accidental ingestion of hexachlorophene are now known, two with fatal outcome, one in an infant and one in an older child. This report was prompted by the fact that the course of prolonged accidental ingestion of hexachlorophene in an infant, with survival, has not as yet been encountered in the literature. Report of Case A male infant was delivered to a gravida 4, Para 2, white mother after an References 1. New and Nonofficial Drugs , Philadelphia: J. B. Lippincott Co., 1964. 2. Hexachlorophene Toxicity , National Clearing House for Poison Control Centers ( (Sept) -Oct) 1962. 3. Oster, K., and Giarman, N.J.: " Chemotherapy of Bacterial Infections: 1. Antiseptics and Germicides ," in DiPalma, J. R. (ed.): Drill's Pharmacology in Medicine , ed 3, New York: McGraw-Hill Book Co., Inc., 1965. 4. Beckman, H.: Pharmacology: The Nature, Action, and Use of Drugs , ed 2, Philadelphia: W. B. Saunders Co., 1961. 5. Chung, H.L., et al: Hexachlorophene (G-11) as a New Specific Drug Against Clonorchiasis Sinensis: Its Efficacy and Toxicity in Experimental and Human Infection , Chin Med J 82: 691, 1963. 6. Florestano, H.J.: Tuberculocidal Activity and Toxicity of Some Diphenylmethane Derivatives , J Pharmacol Exp Ther 96:238, 1949. 7. Wear, J.B., Jr.; Shanahan, R.; and Ratliff, R.K.: Toxicity of Ingested Hexachlorophene , JAMA 181:587, 1962.Crossref 8. Lustig, F.W.: A Fatal Case of Hexachlorophene (pHisoHex) Poisoning , Med J Aust 1:737, 1963. 9. Communication to author from Winthrop Laboratories, March, 1965. 10. Dreisbach, R.H.: Handbook of Poisoning , Los Altos, Calif.: Lange Medical Publications, 1963 11. pHisoHex: An Appraisal After 15 Years of Clinical Use, Winthrop Laboratories, 1963. 12. Wit, J.G., and van Genderen, H.: Some Aspects of the Fate of Hexachlorophene (2.2' Methylene Bis 3.4.6 Trichlorophenol) in Rabbits, Rats, and Dairy Cattle , Acta Physiol Pharmacol Neerl 11:123, 1962. 13. Herter, W.B.: Hexachlorophene Poisoning , Kaiser Foundation Medical Bulletin 7:228, 1959. 14. von Oettingen, W.F.: Poisoning: A Guide to Clinical Diagnosis and Treatment , Philadelphia: W. B. Saunders Co., 1958.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Mar 1, 1966

References