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Heterotransplantation of the Pancreatic Islet Cell Mass From Sheep to Dogs

Heterotransplantation of the Pancreatic Islet Cell Mass From Sheep to Dogs Abstract PREVIOUS studies in this laboratory have indicated the technical feasibility1-4 of pancreatic homotransplantation and suggested that the islet cell homograft might be less subject to rejection than the acinar tissue. In one of the pancreatic homografts, the islet cell tissue continued to function for as long as 75 days with no effort having been made to modify the rejection process.3 Since clinical application is the ultimate goal, and because of the difficulty inherent in obtaining pancreatic homografts as well as the potential desirability of transplanting the islet cell mass only, evaluation of heterotransplantation of the islet cell mass was elected. Methods A colony of 13 sheep was established, and in 11 of this group, the pancreatic ducts were divided and ligated at their point of entrance into the duodenum. The abdomen was then closed and the pancreas allowed to undergo fibrosis with destruction of the acini. Following ligation, References 1. DeJode, L.R., and Howard, J.M.: Studies in Pancreaticoduodenal Homotransplantation , Surg Gynec Obstet 114:553-558 ( (May) ) 1962. 2. Seddon, J.A., and Howard, J.M.: The Exocrine Behavior of the Homotransplanted Pancreas , Surgery 59:226-234 ( (Feb) ) 1966. 3. Seddon, J.A., and Howard, J.M.: The Endocrine Function of the Homotransplanted Pancreas , Surgery 59:235-242 ( (Feb) ) 1966. 4. Chaya, A.; Appert, H.E.; and Howard, J.M.: Canine Allografts (Homografts) of Islet Cell Tissue , Arch Surg 93:598-605 ( (Oct) ) 1966.Crossref 5. Somogyi, M.: Notes on Sugar Determination , J Biol Chem 195:19-23 ( (March) ) 1952. 6. Hales, C.N., and Randle, P.J.: Immunoassay of Insulin With Insulin-Antibody Precipitate , Biochem J 88:137-146 ( (Jan) ) 1963. 7. Reemtsma, K., et al: Islet Cell Function of the Transplanted Canine Pancreas , Ann Surg 158:645-654 ( (Oct) ) 1963.Crossref 8. Bergan, J.J., et al: Total Pancreatic Allografts in Pancreatectomized Dogs , Arch Surg 90:521-526 ( (April) ) 1965.Crossref 9. Schoeffling, K., et al: Serum Insulin-Like Activity in Hypophysectomized and Depancreatized (Houssay) Dogs , Diabetes 14:658-662 ( (Oct) ) 1965. 10. Samaan, N.; Fraser, R.; and Dempster, W.J.: The "Typical" and "Atypical" Forms of Serum Insulin , Diabetes 12:339-348 ( (July) -Aug) 1963. 11. Perper, R.J., and Najarian, J.S.: Experimental Renal Heterotransplantation , Transplantation 4:377-388 ( (July) ) 1966.Crossref 12. Starzl, T.E., et al: Renal Heterotransplantation From Baboon to Man: Experience With Six Cases , Transplantation 2:752-775 ( (Nov) ) 1964.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Heterotransplantation of the Pancreatic Islet Cell Mass From Sheep to Dogs

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Publisher
American Medical Association
Copyright
Copyright © 1968 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1968.01340010148019
Publisher site
See Article on Publisher Site

Abstract

Abstract PREVIOUS studies in this laboratory have indicated the technical feasibility1-4 of pancreatic homotransplantation and suggested that the islet cell homograft might be less subject to rejection than the acinar tissue. In one of the pancreatic homografts, the islet cell tissue continued to function for as long as 75 days with no effort having been made to modify the rejection process.3 Since clinical application is the ultimate goal, and because of the difficulty inherent in obtaining pancreatic homografts as well as the potential desirability of transplanting the islet cell mass only, evaluation of heterotransplantation of the islet cell mass was elected. Methods A colony of 13 sheep was established, and in 11 of this group, the pancreatic ducts were divided and ligated at their point of entrance into the duodenum. The abdomen was then closed and the pancreas allowed to undergo fibrosis with destruction of the acini. Following ligation, References 1. DeJode, L.R., and Howard, J.M.: Studies in Pancreaticoduodenal Homotransplantation , Surg Gynec Obstet 114:553-558 ( (May) ) 1962. 2. Seddon, J.A., and Howard, J.M.: The Exocrine Behavior of the Homotransplanted Pancreas , Surgery 59:226-234 ( (Feb) ) 1966. 3. Seddon, J.A., and Howard, J.M.: The Endocrine Function of the Homotransplanted Pancreas , Surgery 59:235-242 ( (Feb) ) 1966. 4. Chaya, A.; Appert, H.E.; and Howard, J.M.: Canine Allografts (Homografts) of Islet Cell Tissue , Arch Surg 93:598-605 ( (Oct) ) 1966.Crossref 5. Somogyi, M.: Notes on Sugar Determination , J Biol Chem 195:19-23 ( (March) ) 1952. 6. Hales, C.N., and Randle, P.J.: Immunoassay of Insulin With Insulin-Antibody Precipitate , Biochem J 88:137-146 ( (Jan) ) 1963. 7. Reemtsma, K., et al: Islet Cell Function of the Transplanted Canine Pancreas , Ann Surg 158:645-654 ( (Oct) ) 1963.Crossref 8. Bergan, J.J., et al: Total Pancreatic Allografts in Pancreatectomized Dogs , Arch Surg 90:521-526 ( (April) ) 1965.Crossref 9. Schoeffling, K., et al: Serum Insulin-Like Activity in Hypophysectomized and Depancreatized (Houssay) Dogs , Diabetes 14:658-662 ( (Oct) ) 1965. 10. Samaan, N.; Fraser, R.; and Dempster, W.J.: The "Typical" and "Atypical" Forms of Serum Insulin , Diabetes 12:339-348 ( (July) -Aug) 1963. 11. Perper, R.J., and Najarian, J.S.: Experimental Renal Heterotransplantation , Transplantation 4:377-388 ( (July) ) 1966.Crossref 12. Starzl, T.E., et al: Renal Heterotransplantation From Baboon to Man: Experience With Six Cases , Transplantation 2:752-775 ( (Nov) ) 1964.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Jul 1, 1968

References