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Herpetism

Herpetism Abstract Herpetism, an abnormal constitutional condition predisposing to herpes (Webster's New International Dictionary, ed 2, Springfield, Mass, G & C Merriam Co, 1923, p 1010; French: herpétisme), as manifest by recurrent lesions, is an increasingly common and distressing problem. It results from an infection with either the orofacial (type 1) or the genital (type 2) herpes simplex virus. After primary infection of skin or mucosa the virus makes its way to the nuclei of the cells of the regional nerve ganglia. Incorporation of the viral DNA into the host DNA1 provides an impregnable intracellular site for a lifelong infection beyond the reach of antibody, cell-mediated immune responses, or chemotherapy. As a result of cell mechanisms not yet understood but often triggered by fever, sunburn, emotions, or unknown factors, the latent infection becomes manifest as a recurrent endogenous infection in the cutaneous, ocular, or genital epithelium. Exogenous reinfection is also possible, References 1. Kit S, Kurchak M, Wray W, et al: Binding to chromosomes of herpes simplex-related antigens in biochemically transformed cells . Proc Natl Acad Sci USA 75:3288-3291, 1978.Crossref 2. Hartman MD, Ziegler RJ: The relative ability of immunological defense mechanism to inhibit herpes simplex virus replication in rat dorsal root ganglia cultures , in Abstracts of the Annual Meeting of the American Society for Microbiology—1978 . Washington, DC, American Society for Microbiology, 1978, p 252. 3. Pazin GJ, Monto H, Jannetta PJ: Reactivation of herpes simplex virus after decompression of the trigeminal nerve root . J Infect Dis 138:405, 1978.Crossref 4. Naraqi S, Jackson GG, Jonasson O, et al: Prospective study of prevalence, incidence and source of herpes-virus infections in patients with renal allografts . J Infect Dis 136:531-540, 1977.Crossref 5. Rand KH, Rasmussen LE, Pollard RB, et al: Cellular immunity and herpesvirus infections in cardiac-transplant patients . N Engl J Med 296:1372-1377, 1977.Crossref 6. Romano TJ, Shore SL: Lysis of virus infected target cells by antibody dependent cellular cytotoxicity . Cell Immunol 30:66-81, 1977.Crossref 7. Shillitoe EJ, Wilton JMA, Lehner T: Sequential changes in cell mediated immune responses to herpes simplex virus after recurrent herpetic infection in humans . Infect Immun 18:130-137, 1977. 8. Rasmussen L, Merigan TC: Role of T lymphocytes in cellular immune responses during herpes simplex virus infection in humans . Proc Natl Acad Sci USA 75:3957-3961, 1978.Crossref 9. Reichman RC, Dolin R, Vincent MM, et al: Cell-mediated cytotoxicity in recurrent herpes simplex virus infections in man . Proc Soc Exp Biol Med 155:571-576, 1977.Crossref 10. Costa J, Rabson AS, Yee C, et al: Immunoglobulin binding to herpes virus-induced Fc receptors inhibits virus growth . Nature 269:251-252, 1977.Crossref 11. Adler R, Glorioso JP, Cossman J, et al: Possible role of Fc receptors on cells infected and transformed by herpesvirus: Escape from immune cytolysis . Infect Immun 21:442-447, 1978. 12. Daniels CA, LeGoff SG, Notkins AL: Shedding of infectious virus/antibody complexes from vesicular lesions of patients with recurrent herpes labialis . Lancet 2:524-528, 1975.Crossref 13. Kazmierowski JA, Wuepper KD: Erythema multiforme: Immune complex vasculitis of the superficial cutaneous microvasculature . J Invest Dermatol 71:366, 1978.Crossref 14. Kalimo K: Rheumatoid factor in sera of dermatitis herpetiformis patients . Br J Dermatol 98:79-83, 1978.Crossref 15. Strnad BC, Aurelian L: Proteins of herpesvirus type 2 . Virology 87:401-415, 1978.Crossref 16. Kitces EN, Morahan PS, Tew TG, et al: Protection from oral herpes simplex virus infection by a nucleic acid-free vaccine . Infect Immun 16:955-960, 1977. 17. Cohen GH, Katze M, Hydrean-Stern C, et al: Type-common of CP-1 antigen of herpes simplex virus is associated with a 59,000-molecular-weight envelope glycoprotein . J Virol 27:172-181, 1978. 18. Wise TG, Pavan PR, Ennis FA: Herpes simplex virus vaccines . J Infect Dis 136:706-711, 1977.Crossref 19. Russell AS, Brisson E, Grace M: A double blind, controlled trial of levamisole in the treatment of recurrent herpes labialis . J Infect Dis 137:597-600, 1978.Crossref 20. Whitley RJ, Soong SJ, Dolin R, et al: Adenine arabinoside therapy of biopsy-proved herpes simplex encephalitis . N Engl J Med 297:289-294, 1977.Crossref 21. Spruance SL, Crumpacker CS, Haines H, et al: Ineffectiveness of topical adenine arabinoside 5′-monophosphate in recurrent herpes labialis . N Engl J Med 300:1180-1184, 1979.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1979 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1979.04010120038016
Publisher site
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Abstract

Abstract Herpetism, an abnormal constitutional condition predisposing to herpes (Webster's New International Dictionary, ed 2, Springfield, Mass, G & C Merriam Co, 1923, p 1010; French: herpétisme), as manifest by recurrent lesions, is an increasingly common and distressing problem. It results from an infection with either the orofacial (type 1) or the genital (type 2) herpes simplex virus. After primary infection of skin or mucosa the virus makes its way to the nuclei of the cells of the regional nerve ganglia. Incorporation of the viral DNA into the host DNA1 provides an impregnable intracellular site for a lifelong infection beyond the reach of antibody, cell-mediated immune responses, or chemotherapy. As a result of cell mechanisms not yet understood but often triggered by fever, sunburn, emotions, or unknown factors, the latent infection becomes manifest as a recurrent endogenous infection in the cutaneous, ocular, or genital epithelium. Exogenous reinfection is also possible, References 1. Kit S, Kurchak M, Wray W, et al: Binding to chromosomes of herpes simplex-related antigens in biochemically transformed cells . Proc Natl Acad Sci USA 75:3288-3291, 1978.Crossref 2. Hartman MD, Ziegler RJ: The relative ability of immunological defense mechanism to inhibit herpes simplex virus replication in rat dorsal root ganglia cultures , in Abstracts of the Annual Meeting of the American Society for Microbiology—1978 . Washington, DC, American Society for Microbiology, 1978, p 252. 3. Pazin GJ, Monto H, Jannetta PJ: Reactivation of herpes simplex virus after decompression of the trigeminal nerve root . J Infect Dis 138:405, 1978.Crossref 4. Naraqi S, Jackson GG, Jonasson O, et al: Prospective study of prevalence, incidence and source of herpes-virus infections in patients with renal allografts . J Infect Dis 136:531-540, 1977.Crossref 5. Rand KH, Rasmussen LE, Pollard RB, et al: Cellular immunity and herpesvirus infections in cardiac-transplant patients . N Engl J Med 296:1372-1377, 1977.Crossref 6. Romano TJ, Shore SL: Lysis of virus infected target cells by antibody dependent cellular cytotoxicity . Cell Immunol 30:66-81, 1977.Crossref 7. Shillitoe EJ, Wilton JMA, Lehner T: Sequential changes in cell mediated immune responses to herpes simplex virus after recurrent herpetic infection in humans . Infect Immun 18:130-137, 1977. 8. Rasmussen L, Merigan TC: Role of T lymphocytes in cellular immune responses during herpes simplex virus infection in humans . Proc Natl Acad Sci USA 75:3957-3961, 1978.Crossref 9. Reichman RC, Dolin R, Vincent MM, et al: Cell-mediated cytotoxicity in recurrent herpes simplex virus infections in man . Proc Soc Exp Biol Med 155:571-576, 1977.Crossref 10. Costa J, Rabson AS, Yee C, et al: Immunoglobulin binding to herpes virus-induced Fc receptors inhibits virus growth . Nature 269:251-252, 1977.Crossref 11. Adler R, Glorioso JP, Cossman J, et al: Possible role of Fc receptors on cells infected and transformed by herpesvirus: Escape from immune cytolysis . Infect Immun 21:442-447, 1978. 12. Daniels CA, LeGoff SG, Notkins AL: Shedding of infectious virus/antibody complexes from vesicular lesions of patients with recurrent herpes labialis . Lancet 2:524-528, 1975.Crossref 13. Kazmierowski JA, Wuepper KD: Erythema multiforme: Immune complex vasculitis of the superficial cutaneous microvasculature . J Invest Dermatol 71:366, 1978.Crossref 14. Kalimo K: Rheumatoid factor in sera of dermatitis herpetiformis patients . Br J Dermatol 98:79-83, 1978.Crossref 15. Strnad BC, Aurelian L: Proteins of herpesvirus type 2 . Virology 87:401-415, 1978.Crossref 16. Kitces EN, Morahan PS, Tew TG, et al: Protection from oral herpes simplex virus infection by a nucleic acid-free vaccine . Infect Immun 16:955-960, 1977. 17. Cohen GH, Katze M, Hydrean-Stern C, et al: Type-common of CP-1 antigen of herpes simplex virus is associated with a 59,000-molecular-weight envelope glycoprotein . J Virol 27:172-181, 1978. 18. Wise TG, Pavan PR, Ennis FA: Herpes simplex virus vaccines . J Infect Dis 136:706-711, 1977.Crossref 19. Russell AS, Brisson E, Grace M: A double blind, controlled trial of levamisole in the treatment of recurrent herpes labialis . J Infect Dis 137:597-600, 1978.Crossref 20. Whitley RJ, Soong SJ, Dolin R, et al: Adenine arabinoside therapy of biopsy-proved herpes simplex encephalitis . N Engl J Med 297:289-294, 1977.Crossref 21. Spruance SL, Crumpacker CS, Haines H, et al: Ineffectiveness of topical adenine arabinoside 5′-monophosphate in recurrent herpes labialis . N Engl J Med 300:1180-1184, 1979.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Dec 1, 1979

References