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Herpesviruses in Multiple Sclerosis

Herpesviruses in Multiple Sclerosis Abstract In this issue of the Archives, Sanders et al1 report on the presence of herpes simplex virus (HSV) 1 and 2 in 46% of postmortem brain tissue samples from patients with multiple sclerosis and in 28% of samples from control cases. In the August 1995 issue of the Proceedings of the National Academy of Science, Challoner et al2 report on the presence of human herpesvirus 6 (HHV-6) in brain samples from patients with MS. These two articles represent the latest among many reports of viruses detected in MS brain by culture, hybridization techniques, or immunocytochemical methods. Are these simply observations on the normal viral flora found in the brain, perhaps enhanced in the MS brains by the use of immunosuppressive agents and steroids? While the observations on HHV-6 have been met with underwhelming enthusiasm, there are a number of reasons why such observations deserve careful examination. See also References 1. Sanders VJ, Waddell AE, Felisan SL, Li X, Conrad AJ, Tourtellotte WW. Herpes simplex virus in postmortem multiple sclerosis brain tissue . Arch Neurol . 1996; 53:125.Crossref 2. Challoner PB, Smith KT, Parker JD, et al. Plaque-associated expression of human herpesvirus 6 in multiple sclerosis . Proc Natl Acad Sci . 1995;92:7440-7444.Crossref 3. Johnson RT. Viral Infections of the Nervous System . New York, NY: Raven Press; 1982. 4. Ellison GW. Multiple sclerosis: a fever blister on the brain . Lancet . 1974;2:664.Crossref 5. Nelson DA. Dorsal root ganglia may be reservoirs of viral infection in multiple sclerosis . Med Hypotheses . 1993;40:278-283.Crossref 6. Lyke J, Svennerholm BO, Hjelmqvist E, et al. Acyclovir treatment of relapsing-remitting multiple sclerosis: a randomized placebo controlled, double-blind study . In: Program and abstracts of the Multiple Sclerosis Satellite Symposium Following the 15th World Congress of Neurology ; September 11-14, 1993; Victoria, British Columbia. Abstract 2-16. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Herpesviruses in Multiple Sclerosis

Archives of Neurology , Volume 53 (2) – Feb 1, 1996

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Publisher
American Medical Association
Copyright
Copyright © 1996 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1996.00550020027011
Publisher site
See Article on Publisher Site

Abstract

Abstract In this issue of the Archives, Sanders et al1 report on the presence of herpes simplex virus (HSV) 1 and 2 in 46% of postmortem brain tissue samples from patients with multiple sclerosis and in 28% of samples from control cases. In the August 1995 issue of the Proceedings of the National Academy of Science, Challoner et al2 report on the presence of human herpesvirus 6 (HHV-6) in brain samples from patients with MS. These two articles represent the latest among many reports of viruses detected in MS brain by culture, hybridization techniques, or immunocytochemical methods. Are these simply observations on the normal viral flora found in the brain, perhaps enhanced in the MS brains by the use of immunosuppressive agents and steroids? While the observations on HHV-6 have been met with underwhelming enthusiasm, there are a number of reasons why such observations deserve careful examination. See also References 1. Sanders VJ, Waddell AE, Felisan SL, Li X, Conrad AJ, Tourtellotte WW. Herpes simplex virus in postmortem multiple sclerosis brain tissue . Arch Neurol . 1996; 53:125.Crossref 2. Challoner PB, Smith KT, Parker JD, et al. Plaque-associated expression of human herpesvirus 6 in multiple sclerosis . Proc Natl Acad Sci . 1995;92:7440-7444.Crossref 3. Johnson RT. Viral Infections of the Nervous System . New York, NY: Raven Press; 1982. 4. Ellison GW. Multiple sclerosis: a fever blister on the brain . Lancet . 1974;2:664.Crossref 5. Nelson DA. Dorsal root ganglia may be reservoirs of viral infection in multiple sclerosis . Med Hypotheses . 1993;40:278-283.Crossref 6. Lyke J, Svennerholm BO, Hjelmqvist E, et al. Acyclovir treatment of relapsing-remitting multiple sclerosis: a randomized placebo controlled, double-blind study . In: Program and abstracts of the Multiple Sclerosis Satellite Symposium Following the 15th World Congress of Neurology ; September 11-14, 1993; Victoria, British Columbia. Abstract 2-16.

Journal

Archives of NeurologyAmerican Medical Association

Published: Feb 1, 1996

References