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Herpes Zoster Optic Neuritis in Human Immunodeficiency Virus Infection

Herpes Zoster Optic Neuritis in Human Immunodeficiency Virus Infection Abstract To the Editor. —Two individuals with presumed herpes zoster optic neuritis associated with human immunodeficiency virus (HIV) infection have been described to date.1,2 One patient demonstrated improvement of visual acuity following intravenous acyclovir therapy.1 Neither individual received systemic corticosteroids. We present a third patient with presumed varicella zoster optic neuritis in whom visual acuity rapidly deteriorated to no light perception despite aggressive intravenous acyclovir and corticosteroid treatment. Report of a Case. —A 40-year-old HIV-positive woman developed a vesicular eruption involving the ophthalmic division of the right trigeminal nerve accompanied by several small dendritic corneal lesions and an anterior uveitis of the right eye. Visual acuity was 20/40 OD and 20/20 OS. A diagnosis of herpes zoster ophthalmicus was made, and the patient underwent a 10-day course of intravenous acyclovir (4 g/d). During hospitalization, a thorough infectious evaluation was negative for other opportunistic infections associated with HIV infection, including cytomegalovirus, References 1. Winward KE, Hamed LM, Glaser JS. The spectrum of optic nerve disease in human immunodeficiency virus infection . Am J Ophthalmol . 1989;107:373-380. 2. Sandor EV, Millman A, Croxson TS, Mildvan D. Herpes zoster ophthalmicus in patients at risk for the acquired immune deficiency syndrome (AIDS) . Am J Ophthalmol . 1986;101:153-155. 3. Carter JB, Hamill RJ, Matoba AY. Bilateral syphilitic optic neuritis in a patient with a positive test for HIV . Arch Ophthalmol . 1987;105:1485-1486.Crossref 4. Jabs DA, Green WR, Fox R, Polk BF, Bartlett JG. Ocular manifestations of acquired immune deficiency syndrome . Ophthalmology . 1989;96:1092-1099.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Herpes Zoster Optic Neuritis in Human Immunodeficiency Virus Infection

Archives of Ophthalmology , Volume 108 (6) – Jun 1, 1990

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Publisher
American Medical Association
Copyright
Copyright © 1990 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1990.01070080024018
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor. —Two individuals with presumed herpes zoster optic neuritis associated with human immunodeficiency virus (HIV) infection have been described to date.1,2 One patient demonstrated improvement of visual acuity following intravenous acyclovir therapy.1 Neither individual received systemic corticosteroids. We present a third patient with presumed varicella zoster optic neuritis in whom visual acuity rapidly deteriorated to no light perception despite aggressive intravenous acyclovir and corticosteroid treatment. Report of a Case. —A 40-year-old HIV-positive woman developed a vesicular eruption involving the ophthalmic division of the right trigeminal nerve accompanied by several small dendritic corneal lesions and an anterior uveitis of the right eye. Visual acuity was 20/40 OD and 20/20 OS. A diagnosis of herpes zoster ophthalmicus was made, and the patient underwent a 10-day course of intravenous acyclovir (4 g/d). During hospitalization, a thorough infectious evaluation was negative for other opportunistic infections associated with HIV infection, including cytomegalovirus, References 1. Winward KE, Hamed LM, Glaser JS. The spectrum of optic nerve disease in human immunodeficiency virus infection . Am J Ophthalmol . 1989;107:373-380. 2. Sandor EV, Millman A, Croxson TS, Mildvan D. Herpes zoster ophthalmicus in patients at risk for the acquired immune deficiency syndrome (AIDS) . Am J Ophthalmol . 1986;101:153-155. 3. Carter JB, Hamill RJ, Matoba AY. Bilateral syphilitic optic neuritis in a patient with a positive test for HIV . Arch Ophthalmol . 1987;105:1485-1486.Crossref 4. Jabs DA, Green WR, Fox R, Polk BF, Bartlett JG. Ocular manifestations of acquired immune deficiency syndrome . Ophthalmology . 1989;96:1092-1099.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Jun 1, 1990

References