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Herpes Zoster in Normal and Immunocompromised Children

Herpes Zoster in Normal and Immunocompromised Children Abstract Primary infection with varicellazoster virus (VZV) causes chickenpox. After the primary infection, the virus remains dormant in the sensory ganglionic neurons until reactivated.1 The mechanism of reactivation is poorly understood, but various insults like malignant neoplasms, irradiation, immunosuppressive therapy, or aging cause reactivation of the virus, producing lesions of herpes zoster (shingles).2 While the incidence of chickenpox is greatest among the 5- to 9-year-old age group,3 the incidence of zoster, which may occur at any age after primary varicella infection, increases sharply after the age of 50 years.4 Herpes zoster in otherwise normal children occurs without any obvious predisposing cause. Extensive data are available regarding herpes zoster in adults2 and immunocompromised children,5-7 but little is known about this disease in immunologically competent children.8-10 We have compared the epidemiologic and clinical features of herpes zoster occurring in seven otherwise normal children with the same References 1. Dolin R, Reichman RC, Mazur MH, et al: Herpes zoster varicella infections in immunosuppressed patients . Ann Intern Med 1978;89:375-388.Crossref 2. Mazur MH, Dolin R: Herpes zoster at the NIH: A 20 year experience . Am J Med 1978;65: 738-744.Crossref 3. Preblud SR: Age-specific risks of varicella complications . Pediatrics 1981;68:14-17. 4. Hope-Simpson RE: The nature of herpes zoster: A long term study and a new hypothesis . Proc R Soc Med 1965;58:9-20. 5. Hurley JK, Greenslade T, Lewy PR, et al: Varicella-zoster infections in pediatric renal transplant recipients . Arch Surg 1980;115:751-752.Crossref 6. Feldman S, Hughes WT, Kim HY: Herpes zoster in children with cancer . Am J Dis Child 1973;126:178-184. 7. Bacon GE, Oliver WJ, Shapiro BA: Factors contributing to severity of herpes zoster in children . J Pediatr 1965;67:768-771.Crossref 8. Winkelmann RK, Perry HO: Herpes zoster in children . JAMA 1959;171:876-880.Crossref 9. Brunell PA, Miller LH, Lovejoy F: Zoster in children . Am J Dis Child 1968;115:432-437. 10. Rogers RS, Tindall JP: Herpes zoster in children . Arch Dermatol 1972;106:204-207.Crossref 11. Brunell PA: Zoster in infancy: Failure to maintain virus latency following intrauterine infection . J Pediatr 1981;98:71-73.Crossref 12. Timothy DJ, Williams ML: Herpes zoster in infancy . Scand J Infect Dis 1979;11:185-186. 13. Takahashi M, Asano Y, Kamiya H, et al: Active immunization for varicella-zoster virus , in Nahmias AJ, Dowdle WR, Schinazi RF (eds): The Human Herpesvirus . New York, Elsevier North Holland Inc, 1981, pp 414-431. 14. Brunell PA, Shehab Z, Geiser C, et al: Administration of live varicella vaccine to children with leukemia . Lancet 1982;2:1069-1073.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Herpes Zoster in Normal and Immunocompromised Children

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References (16)

Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1983.02140340081021
Publisher site
See Article on Publisher Site

Abstract

Abstract Primary infection with varicellazoster virus (VZV) causes chickenpox. After the primary infection, the virus remains dormant in the sensory ganglionic neurons until reactivated.1 The mechanism of reactivation is poorly understood, but various insults like malignant neoplasms, irradiation, immunosuppressive therapy, or aging cause reactivation of the virus, producing lesions of herpes zoster (shingles).2 While the incidence of chickenpox is greatest among the 5- to 9-year-old age group,3 the incidence of zoster, which may occur at any age after primary varicella infection, increases sharply after the age of 50 years.4 Herpes zoster in otherwise normal children occurs without any obvious predisposing cause. Extensive data are available regarding herpes zoster in adults2 and immunocompromised children,5-7 but little is known about this disease in immunologically competent children.8-10 We have compared the epidemiologic and clinical features of herpes zoster occurring in seven otherwise normal children with the same References 1. Dolin R, Reichman RC, Mazur MH, et al: Herpes zoster varicella infections in immunosuppressed patients . Ann Intern Med 1978;89:375-388.Crossref 2. Mazur MH, Dolin R: Herpes zoster at the NIH: A 20 year experience . Am J Med 1978;65: 738-744.Crossref 3. Preblud SR: Age-specific risks of varicella complications . Pediatrics 1981;68:14-17. 4. Hope-Simpson RE: The nature of herpes zoster: A long term study and a new hypothesis . Proc R Soc Med 1965;58:9-20. 5. Hurley JK, Greenslade T, Lewy PR, et al: Varicella-zoster infections in pediatric renal transplant recipients . Arch Surg 1980;115:751-752.Crossref 6. Feldman S, Hughes WT, Kim HY: Herpes zoster in children with cancer . Am J Dis Child 1973;126:178-184. 7. Bacon GE, Oliver WJ, Shapiro BA: Factors contributing to severity of herpes zoster in children . J Pediatr 1965;67:768-771.Crossref 8. Winkelmann RK, Perry HO: Herpes zoster in children . JAMA 1959;171:876-880.Crossref 9. Brunell PA, Miller LH, Lovejoy F: Zoster in children . Am J Dis Child 1968;115:432-437. 10. Rogers RS, Tindall JP: Herpes zoster in children . Arch Dermatol 1972;106:204-207.Crossref 11. Brunell PA: Zoster in infancy: Failure to maintain virus latency following intrauterine infection . J Pediatr 1981;98:71-73.Crossref 12. Timothy DJ, Williams ML: Herpes zoster in infancy . Scand J Infect Dis 1979;11:185-186. 13. Takahashi M, Asano Y, Kamiya H, et al: Active immunization for varicella-zoster virus , in Nahmias AJ, Dowdle WR, Schinazi RF (eds): The Human Herpesvirus . New York, Elsevier North Holland Inc, 1981, pp 414-431. 14. Brunell PA, Shehab Z, Geiser C, et al: Administration of live varicella vaccine to children with leukemia . Lancet 1982;2:1069-1073.Crossref

Journal

American Journal of Diseases of Children – American Medical Association

Published: Aug 1, 1983

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