Abstract • In a continuous series of 457 patients with presumed herpetic eye disease, virus isolation and typing revealed 154 patients with herpes simplex virus type 1 and three patients with type 2 infections. In 219 isolates that were examined for neutralization by specific antisera, for growth in human fibroblasts, and, in part, for temperature sensitivity, there were found substantial strain differences in addition to the type-specific characteristics. The clinical features of each of the three type 2 infections are described in detail. A suggestive correlation found between clinical courses and virus growth characteristics of the type 1 strains indicates that further virologic differentiation of these strains would be useful. References 1. Nahmias AJ, Roizman B: Infection with herpes-simplex viruses 1 and 2 . N Engl J Med 289:781-789, 1973.Crossref 2. Kobayashi S, Shoji K, Ishizu M, et al: Herpetic keratitis: From virological standpoint . Acta Soc Ophthalmol Jpn 76:1454-1474, 1973. 3. Sawanobori S, Tanaka N, Goto E: Classification of herpes virus isolates from ocular lesions . Acta Soc Ophthalmol Jpn 77:521-530, 1973. 4. Wolontis S, Jeansson S: Correlation of herpes simplex virus types 1 and 2 with clinical feature of infection . J Infect Dis 135:28-33, 1977.Crossref 5. Hagler WS, Walters PV, Nahmias AJ: Ocular involvement in neonatal herpes simplex virus infection . Arch Ophthalmol 82:169-176, 1969.Crossref 6. Oh JO, Kimura SJ, Ostler HB: Acute ocular infection by type 2 herpes simplex virus in adults: Report of two cases . Arch Ophthalmol 93:1127-1129, 1975.Crossref 7. Sundmacher R, Neumann-Haefelin D, Manthey KF, et al: Interferon in treatment of dentritic keratitis in humans: A preliminary report . J Infect Dis 133( (suppl) ):160-164, 1976.Crossref 8. Sundmacher R, Neumann-Haefelin D, Cantell K: Successful treatment of dendritic keratitis with human leukocyte interferon: A controlled clinical study . Albrecht von Graefes Arch Klin Ophthalmol 201:39-45, 1976.Crossref 9. Sundmacher R, Neumann-Haefelin D: Keratitis metaherpetica—klinische und virologische Befunde . Klin Monatsbl Augenheilkd 169:728-737, 1976. 10. Neumann-Haefelin D, Sundmacher R, Sauter B, et al: Effect of human leukocyte interferon on vaccinia- and herpes virus-infected cell cultures and monkey corneas . Infect Immun 12:148-155, 1975. 11. Jeansson S: Preparation of type specific herpes simplex antisera by an immunosorbent method . Acta Pathol Microbiol Scand B 83:48-54, 1975. 12. Stalder H, Oxman MN, Kenneth LH: Herpes simplex virus microneutralization: A simplification of the test . J Infect Dis 131:423-430, 1975.Crossref 13. Pauls FP, Dowdle WR: A serologic study of herpesvirus hominis strains by microneutralization tests . J Immunol 98:941-947, 1967. 14. Szanto J: Reproduction in unadapted and adapted cells at 40 C of herpes simplex virus type 1 and type 2 strains . Acta Virol 19:287-292, 1975. 15. Oh JO, Moschini GB, Okumoto M, et al: Ocular pathogenicity of types 1 and 2 herpesvirus hominis in rabbits . Infect Immun 5:412-413, 1972. 16. Oh JO, Stevens TR: Comparison of types 1 and 2 Herpesvirus hominis infection of rabbit eyes: I. Clinical manifestations . Arch Ophthalmol 90:473-476, 1973.Crossref 17. Stevens TR, Oh JO: Comparison of types 1 and 2 Herpesvirus hominis infection of rabbit eyes: II. Histopathologic and virologic studies . Arch Ophthalmol 90:477-480, 1973.Crossref 18. Forrest WM, Kaufman HE: Zosteriform herpes simplex . Am J Ophthalmol 81:86-88, 1976. 19. Korting GW: Haut und Auge: Eine Korrelationsdermatologie der Periorbitalregion . Georg Thieme, Stuttgart, West Germany, 1969, pp 41-42. 20. Person DA, Sheridan PJ, Hermann EC: Sensitivity of types 1 and 2 herpes simplex virus to 5-iodo-2′-deoxyuridine and 9-β-D-arabinofuranosyladenine . Infect Immun 2:815-820, 1970. 21. Sidwell RW, Allen LB, Huffman JH, et al: Anti-DNA virus activity of the 5′-nucleotide and 3′5′-cyclic nucleotide of 9-β-D-arabinofuranosyladenine . Chemotherapy 19:325-340, 1973.Crossref 22. Trobe JD, Centifanto Y, Zam ZS, et al: Anti-herpes activity of adenine arabinoside monophosphate . Invest Ophthalmol 15:196-199, 1976. 23. North RD, Pavan-Langston D, Geary P: Herpes simplex virus types 1 and 2: Therapeutic response to antiviral drugs . Arch Ophthalmol 94:1019-1021, 1976.Crossref
Archives of Ophthalmology – American Medical Association
Published: Jan 1, 1978
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