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Herpes Simplex Virus Antibodies in the Perilymph of Patients With Meniere Disease

Herpes Simplex Virus Antibodies in the Perilymph of Patients With Meniere Disease Abstract Objective: To evaluate the presence of IgG antibodies directed to herpes simplex virus (HSV) in the perilymph of patients with Meniere disease. Design: Antibodies to HSV, Epstein-Barr virus, cytomegalovirus, and measles virus were analyzed in serum and perilymph samples by enzyme-linked immunosorbent assay. Total IgG and albumin in serum and perilymph samples were measured by nephelometer analysis. The relation of specific antivirus IgG in the perilymph vs the serum was expressed as an index. Patients: Perilymph and serum samples from 7 patients with long-standing, disabling Meniere disease were collected during therapeutic vestibulotomy. Perilymph and serum samples from 7 patients with otosclerosis and 2 recipients of cochlear implants were used as controls. Results: Compared with the corresponding serum sample, the perilymph from the patients with Meniere disease disclosed a higher level of specific anti-HSV IgG. An elevated level of specific anti-measles virus IgG in the perilymph was detected in patients with otosclerosis. Patients of all groups showed no variation of specific anti—Epstein Barr virus IgG and anti-cytomegalovirus IgG in the serum or in the perilymph. Conclusions: Our results show the presence of HSV IgG in the perilymph of patients with Meniere disease and support the hypothesis that HSV may play an important role in the etiopathogenesis of Meniere disease.Arch Otolaryngol Head Neck Surg. 1997;123:53-56 References 1. Arnold W, Altermatt HJ. The significance of the human endolymphatic sac and its possible role in Meniere's disease . Acta Otolaryngol (Stockh) . 1995;519:36-42.Crossref 2. Shaver EF. Allergic management of Meniere's disease . Arch Otolaryngol . 1975; 101:96-99.Crossref 3. Roitman R, Talmi YP, Finkelstein Y, et al. Acoustic trauma-induced Meniere's syndrome . ORL J Otorhinolaryngol Relat Spec . 1989;51:246-250.Crossref 4. Williams LL, Lowery NW, Shannon BT. Evidence of persistant viral infection in Meniere's disease . Arch Otolaryngol Head Neck Surg . 1987;113:397-400.Crossref 5. Suzuki S, Furuta Y, Takasu T, et al. The difference in the copy number of herpes simplex virus among the sensory ganglia of human temporal bones. In: Proceedings of the Fourth International Academic Conference on Immunobiology in Otology, Rhinology and Laryngology; 1994: Oita, Japan. 6. Takasu T, Furuta Y, Sato KC, et al. Detection of latent herpes simplex virus DNA and RNA in human geniculate ganglia by the polymerase chain reaction . Acta Otolaryngol (Stockh) . 1992;112:1004-1011.Crossref 7. Bonkowsky V, Niedermeyer H, Endres N, Arnold W. Rolle der Herpes-Simplex-Typ-I Reaktivierung bei der Pathogenese der idiopathischen Fazialisparese . Otorhinolaryngol Nova . 1994;4:186-189.Crossref 8. Bergström T, Edström S, Tjellström A, Vahlne A. Meniere's disease and antibody reactivity to herpes simplex virus type 1 polypeptides . Am J Otolaryngol . 1992;13:295-300.Crossref 9. Calenoff E, Zhao JC, Derlacki EL, et al. Patients with Meniere's disease possess IgE reacting with herpes family viruses . Arch Otolaryngol Head Neck Surg . 1995;121:861-864.Crossref 10. Harris JP. Immunology of the inner ear: evidence of local antibody production . Ann Otol Rhinol Laryngol . 1984;93:157-162. 11. Rask-Andersen H, Bagger-Sjöböck D, Lundquist PG. The fenestrated blood vessels of the endolymphatic sac . Am J Otol . 1983;4:214-221. 12. Arnold W, Altermatt HJ, Gebbers JO, Laissue J. Secretory immunoglobulin A in the human endolymphatic sac. ORL J Otorhinolaryngol Relat Spec . 1984; 46:286-288.Crossref 13. Harris JP, Wool NK, Ryan AF, et al. Immunologic and electrophysiologic response to cytomegaloviral inner ear infection in guinea pig . J Infect Dis . 1984; 150:523-530.Crossref 14. Tomiyama S, Harris JP. The role of the endolymphatic sac in inner ear immunology . Acta Otolaryngol (Stockh) . 1987;103:182-188.Crossref 15. Arnold W, Altermatt HJ, Arnold R, Gebbers JO, Laissue J. Somatostatin (-like) immunoreactive cells in the human inner ear and endolymphatic sac . Arch Otolaryngol Head Neck Surg . 1986;112:934-937.Crossref 16. Niedermeyer HP, Arnold W. Neubert WJ, Höfler H. Evidence of measles virus RNA in otosclerotic tissue . ORL J Otorhinolaryngol Relat Spec . 1994;56:130-132.Crossref 17. Niedermeyer HP, Arnold W. Otosclerosis: a measles virus—associated inflammatory disease . Acta Otolaryngol (Stockh) . 1995;115:300-303.Crossref 18. Davis LE, Johnson RT. Experimental infection of the inner ear: I, acute infections of newborn hamster labyrinth. Lab Invest . 1976;34:349-351. 19. Kristensson K, Svennerholm B, Persson LA, et al. Latent herpes simplex virus trigeminal ganglionic infection in mice and demyelination in the central nervous system . J Neurol Sci . 1979;43:253-264.Crossref 20. Wackym PA, Friberg U, Linthicum FH, et al. Human endolymphatic sac: morphologic evidence of immunologic function . Ann Otol Rhinol Laryngol . 1987; 96:276-281. 21. Kumagami H. Detection of viral antigen in the endolymphatic sac. Eur Arch Otorhinolaryngol . 1996;253:264-267.Crossref 22. Welling DB, Daniels RL, Brainard J, Western LM, Prior TW. Detection of viral DNA in endolymphatic tissue from Meniere's disease patients . Am J Otol . 1994; 15:639-643. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology - Head & Neck Surgery American Medical Association

Herpes Simplex Virus Antibodies in the Perilymph of Patients With Meniere Disease

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Publisher
American Medical Association
Copyright
Copyright © 1997 American Medical Association. All Rights Reserved.
ISSN
0886-4470
eISSN
1538-361X
DOI
10.1001/archotol.1997.01900010061008
Publisher site
See Article on Publisher Site

Abstract

Abstract Objective: To evaluate the presence of IgG antibodies directed to herpes simplex virus (HSV) in the perilymph of patients with Meniere disease. Design: Antibodies to HSV, Epstein-Barr virus, cytomegalovirus, and measles virus were analyzed in serum and perilymph samples by enzyme-linked immunosorbent assay. Total IgG and albumin in serum and perilymph samples were measured by nephelometer analysis. The relation of specific antivirus IgG in the perilymph vs the serum was expressed as an index. Patients: Perilymph and serum samples from 7 patients with long-standing, disabling Meniere disease were collected during therapeutic vestibulotomy. Perilymph and serum samples from 7 patients with otosclerosis and 2 recipients of cochlear implants were used as controls. Results: Compared with the corresponding serum sample, the perilymph from the patients with Meniere disease disclosed a higher level of specific anti-HSV IgG. An elevated level of specific anti-measles virus IgG in the perilymph was detected in patients with otosclerosis. Patients of all groups showed no variation of specific anti—Epstein Barr virus IgG and anti-cytomegalovirus IgG in the serum or in the perilymph. Conclusions: Our results show the presence of HSV IgG in the perilymph of patients with Meniere disease and support the hypothesis that HSV may play an important role in the etiopathogenesis of Meniere disease.Arch Otolaryngol Head Neck Surg. 1997;123:53-56 References 1. Arnold W, Altermatt HJ. The significance of the human endolymphatic sac and its possible role in Meniere's disease . Acta Otolaryngol (Stockh) . 1995;519:36-42.Crossref 2. Shaver EF. Allergic management of Meniere's disease . Arch Otolaryngol . 1975; 101:96-99.Crossref 3. Roitman R, Talmi YP, Finkelstein Y, et al. Acoustic trauma-induced Meniere's syndrome . ORL J Otorhinolaryngol Relat Spec . 1989;51:246-250.Crossref 4. Williams LL, Lowery NW, Shannon BT. Evidence of persistant viral infection in Meniere's disease . Arch Otolaryngol Head Neck Surg . 1987;113:397-400.Crossref 5. Suzuki S, Furuta Y, Takasu T, et al. The difference in the copy number of herpes simplex virus among the sensory ganglia of human temporal bones. In: Proceedings of the Fourth International Academic Conference on Immunobiology in Otology, Rhinology and Laryngology; 1994: Oita, Japan. 6. Takasu T, Furuta Y, Sato KC, et al. Detection of latent herpes simplex virus DNA and RNA in human geniculate ganglia by the polymerase chain reaction . Acta Otolaryngol (Stockh) . 1992;112:1004-1011.Crossref 7. Bonkowsky V, Niedermeyer H, Endres N, Arnold W. Rolle der Herpes-Simplex-Typ-I Reaktivierung bei der Pathogenese der idiopathischen Fazialisparese . Otorhinolaryngol Nova . 1994;4:186-189.Crossref 8. Bergström T, Edström S, Tjellström A, Vahlne A. Meniere's disease and antibody reactivity to herpes simplex virus type 1 polypeptides . Am J Otolaryngol . 1992;13:295-300.Crossref 9. Calenoff E, Zhao JC, Derlacki EL, et al. Patients with Meniere's disease possess IgE reacting with herpes family viruses . Arch Otolaryngol Head Neck Surg . 1995;121:861-864.Crossref 10. Harris JP. Immunology of the inner ear: evidence of local antibody production . Ann Otol Rhinol Laryngol . 1984;93:157-162. 11. Rask-Andersen H, Bagger-Sjöböck D, Lundquist PG. The fenestrated blood vessels of the endolymphatic sac . Am J Otol . 1983;4:214-221. 12. Arnold W, Altermatt HJ, Gebbers JO, Laissue J. Secretory immunoglobulin A in the human endolymphatic sac. ORL J Otorhinolaryngol Relat Spec . 1984; 46:286-288.Crossref 13. Harris JP, Wool NK, Ryan AF, et al. Immunologic and electrophysiologic response to cytomegaloviral inner ear infection in guinea pig . J Infect Dis . 1984; 150:523-530.Crossref 14. Tomiyama S, Harris JP. The role of the endolymphatic sac in inner ear immunology . Acta Otolaryngol (Stockh) . 1987;103:182-188.Crossref 15. Arnold W, Altermatt HJ, Arnold R, Gebbers JO, Laissue J. Somatostatin (-like) immunoreactive cells in the human inner ear and endolymphatic sac . Arch Otolaryngol Head Neck Surg . 1986;112:934-937.Crossref 16. Niedermeyer HP, Arnold W. Neubert WJ, Höfler H. Evidence of measles virus RNA in otosclerotic tissue . ORL J Otorhinolaryngol Relat Spec . 1994;56:130-132.Crossref 17. Niedermeyer HP, Arnold W. Otosclerosis: a measles virus—associated inflammatory disease . Acta Otolaryngol (Stockh) . 1995;115:300-303.Crossref 18. Davis LE, Johnson RT. Experimental infection of the inner ear: I, acute infections of newborn hamster labyrinth. Lab Invest . 1976;34:349-351. 19. Kristensson K, Svennerholm B, Persson LA, et al. Latent herpes simplex virus trigeminal ganglionic infection in mice and demyelination in the central nervous system . J Neurol Sci . 1979;43:253-264.Crossref 20. Wackym PA, Friberg U, Linthicum FH, et al. Human endolymphatic sac: morphologic evidence of immunologic function . Ann Otol Rhinol Laryngol . 1987; 96:276-281. 21. Kumagami H. Detection of viral antigen in the endolymphatic sac. Eur Arch Otorhinolaryngol . 1996;253:264-267.Crossref 22. Welling DB, Daniels RL, Brainard J, Western LM, Prior TW. Detection of viral DNA in endolymphatic tissue from Meniere's disease patients . Am J Otol . 1994; 15:639-643.

Journal

Archives of Otolaryngology - Head & Neck SurgeryAmerican Medical Association

Published: Jan 1, 1997

References

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