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Herpes Simplex Uveitis in Immune Rabbits: Priming Effect of Nonherpetic Uveitis

Herpes Simplex Uveitis in Immune Rabbits: Priming Effect of Nonherpetic Uveitis Abstract • Systemic immunization of rabbits with herpes simplex virus (HSV) had two opposite effects on the outcome of subsequent efforts to produce primary HSV uveitis, the difference depending on whether or not the rabbits had had nonherpetic uveitis before the HSV challenge. In normal eyes, systemic immunization with HSV provided complete protection against the production of primary uveitis by an intraocular injection of HSV; but in eyes that had had a bout of experimentally induced nonherpetic uveitis before the challenge, the same systemic immunization was not protective. In these eyes, an immune-mediated uveal inflammation developed. Nonherpetic uveitis had apparently "primed" the eyes of the HSV-immune rabbits for subsequent immune-mediated HSV uveitis. (Arch Ophthalmol 95:2057-2061, 1977) References 1. Notkins AL: Immunological defense and immunological injury in herpes simplex virus infection , in Mergenhagen SE, Sherp HW (eds): Comparative Immunology of the Oral Cavity . NIH publication, 1973, pp 192-203. 2. Tessler HH, Oh JO: Type 1 and type 2 herpes simplex uveitis in immune rabbits: Importance of pure virus preparation . Can J Ophthalmol 10:277-280, 1975. 3. Oh JO: Primary and secondary herpes simplex uveitis in rabbits . Survey Ophthalmol 21:178-184, 1976.Crossref 4. Reed LJ, Muench H: A simple method of estimating 50% endpoints . Am J Hygiene 27:493-497, 1938. 5. Oh JO, Evans CA: Suppressive effects of pyrilamine maleate and d-lysergic acid diethylamide (LSD-25) on early corneal lesions produced in vitro by Newcastle disease virus (NDV) and compound 48/80 . Virology 10:127-143, 1960.Crossref 6. Hogan MJ, Kimura SJ, Thygeson P: Signs and symptoms of uveitis: I. Anterior uveitis . Am J Ophthalmol 47:155-170, 1959. 7. Wilcox WC, Wood EM, Oh JO, et al: Morphological and functional changes in corneal endothelium caused by the toxic effects of influenza and Newcastle disease viruses . Br J Exp Med 39:601-609, 1958. 8. Taylor FW, Suie T: Effect of trauma on the production of experimental uveitis . Am J Ophthalmol 41:299-301, 1956. 9. Gamble CN, Aronson SB: Experimental uveitis: I. The production of recurrent immunologic (Auer) uveitis and its relationship to increased uveal vascular permeability . Arch Ophthalmol 84:321-330, 1970.Crossref 10. Gery I, Krüger J, Spiesel SZ: Stimulation of B-lymphocytes by endotoxin: Reactions of Thymus-deprived mice and Karyotypic analysis of dividing cells in mice bearing T6T6 thymus grafts . J Immunol 108:1088-1091, 1972. 11. Mergenhagen SE, Rosenstreich DL, Nowotny A, et al: Transformation of mouse B-lymphocytes by the lipid component of endotoxin , in Urbaschek B, Urbaschek R, Neter E (eds): Gram-Negative Bacterial Infections and Mode of Endotoxin Actions . New York, Springer-Verlag, 1975, pp 86-90. 12. Snyderman R, Wohlenberg C, Notkins AL: Inflammation and viral infection: Chemotactic activity resulting from the interaction of antiviral antibody and complement with cells infected with herpes simplex virus . J Infect Dis 126:207-209, 1972.Crossref 13. Rosenberg GL, Snyderman R, Notkins AL: Production of chemotactic factor and lymphotoxin by human leukocytes stimulated with herpes simplex virus . Infect Immunol 10:111-115, 1974. 14. Wentworth BB, Alexander ER: Seroepidemiology of infections due to members of the herpesvirus group . Am J Epidemiol 94:496-507, 1971. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Herpes Simplex Uveitis in Immune Rabbits: Priming Effect of Nonherpetic Uveitis

Archives of Ophthalmology , Volume 95 (11) – Nov 1, 1977

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Publisher
American Medical Association
Copyright
Copyright © 1977 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1977.04450110151021
Publisher site
See Article on Publisher Site

Abstract

Abstract • Systemic immunization of rabbits with herpes simplex virus (HSV) had two opposite effects on the outcome of subsequent efforts to produce primary HSV uveitis, the difference depending on whether or not the rabbits had had nonherpetic uveitis before the HSV challenge. In normal eyes, systemic immunization with HSV provided complete protection against the production of primary uveitis by an intraocular injection of HSV; but in eyes that had had a bout of experimentally induced nonherpetic uveitis before the challenge, the same systemic immunization was not protective. In these eyes, an immune-mediated uveal inflammation developed. Nonherpetic uveitis had apparently "primed" the eyes of the HSV-immune rabbits for subsequent immune-mediated HSV uveitis. (Arch Ophthalmol 95:2057-2061, 1977) References 1. Notkins AL: Immunological defense and immunological injury in herpes simplex virus infection , in Mergenhagen SE, Sherp HW (eds): Comparative Immunology of the Oral Cavity . NIH publication, 1973, pp 192-203. 2. Tessler HH, Oh JO: Type 1 and type 2 herpes simplex uveitis in immune rabbits: Importance of pure virus preparation . Can J Ophthalmol 10:277-280, 1975. 3. Oh JO: Primary and secondary herpes simplex uveitis in rabbits . Survey Ophthalmol 21:178-184, 1976.Crossref 4. Reed LJ, Muench H: A simple method of estimating 50% endpoints . Am J Hygiene 27:493-497, 1938. 5. Oh JO, Evans CA: Suppressive effects of pyrilamine maleate and d-lysergic acid diethylamide (LSD-25) on early corneal lesions produced in vitro by Newcastle disease virus (NDV) and compound 48/80 . Virology 10:127-143, 1960.Crossref 6. Hogan MJ, Kimura SJ, Thygeson P: Signs and symptoms of uveitis: I. Anterior uveitis . Am J Ophthalmol 47:155-170, 1959. 7. Wilcox WC, Wood EM, Oh JO, et al: Morphological and functional changes in corneal endothelium caused by the toxic effects of influenza and Newcastle disease viruses . Br J Exp Med 39:601-609, 1958. 8. Taylor FW, Suie T: Effect of trauma on the production of experimental uveitis . Am J Ophthalmol 41:299-301, 1956. 9. Gamble CN, Aronson SB: Experimental uveitis: I. The production of recurrent immunologic (Auer) uveitis and its relationship to increased uveal vascular permeability . Arch Ophthalmol 84:321-330, 1970.Crossref 10. Gery I, Krüger J, Spiesel SZ: Stimulation of B-lymphocytes by endotoxin: Reactions of Thymus-deprived mice and Karyotypic analysis of dividing cells in mice bearing T6T6 thymus grafts . J Immunol 108:1088-1091, 1972. 11. Mergenhagen SE, Rosenstreich DL, Nowotny A, et al: Transformation of mouse B-lymphocytes by the lipid component of endotoxin , in Urbaschek B, Urbaschek R, Neter E (eds): Gram-Negative Bacterial Infections and Mode of Endotoxin Actions . New York, Springer-Verlag, 1975, pp 86-90. 12. Snyderman R, Wohlenberg C, Notkins AL: Inflammation and viral infection: Chemotactic activity resulting from the interaction of antiviral antibody and complement with cells infected with herpes simplex virus . J Infect Dis 126:207-209, 1972.Crossref 13. Rosenberg GL, Snyderman R, Notkins AL: Production of chemotactic factor and lymphotoxin by human leukocytes stimulated with herpes simplex virus . Infect Immunol 10:111-115, 1974. 14. Wentworth BB, Alexander ER: Seroepidemiology of infections due to members of the herpesvirus group . Am J Epidemiol 94:496-507, 1971.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Nov 1, 1977

References