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Mcculloch (1943)
The epidemiology of rheumatic fever and some of its public health aspectsThe Journal of Pediatrics, 22
M. Wilson, M. Schweitzer, R. Lubschez (1943)
The familial epidemiology of rheumatic fever genetic and epidemiologic studiesThe Journal of Pediatrics, 22
At the present time rheumatic fever holds a prominent place in medical discussion and investigation. It is generally agreed that, although the nature of the disease is obscure, susceptibility of the host is the primary factor in the development of rheumatic fever. That this susceptibility is on an age and genetic basis is supported by considerable evidence.1 For more than fifty years there has been a widespread clinical impression that heredity is a significant factor in the observed concentration of rheumatic fever in certain families. This belief was based in large measure on the observed familial incidence of the disease. Recent family studies have been in accord with this observation.2 Since familial concentration is commonly observed in contagious, dietary and parasitic disorders, a disease may not be considered hereditary on the basis of a high familial incidence alone. Nonhereditary factors must be excluded, and the operation of hereditary
JAMA – American Medical Association
Published: Apr 22, 1944
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