Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

HEREDITARY SUSCEPTIBILITY IN RHEUMATIC FEVER

HEREDITARY SUSCEPTIBILITY IN RHEUMATIC FEVER At the present time rheumatic fever holds a prominent place in medical discussion and investigation. It is generally agreed that, although the nature of the disease is obscure, susceptibility of the host is the primary factor in the development of rheumatic fever. That this susceptibility is on an age and genetic basis is supported by considerable evidence.1 For more than fifty years there has been a widespread clinical impression that heredity is a significant factor in the observed concentration of rheumatic fever in certain families. This belief was based in large measure on the observed familial incidence of the disease. Recent family studies have been in accord with this observation.2 Since familial concentration is commonly observed in contagious, dietary and parasitic disorders, a disease may not be considered hereditary on the basis of a high familial incidence alone. Nonhereditary factors must be excluded, and the operation of hereditary http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

HEREDITARY SUSCEPTIBILITY IN RHEUMATIC FEVER

JAMA , Volume 124 (17) – Apr 22, 1944

Loading next page...
 
/lp/american-medical-association/hereditary-susceptibility-in-rheumatic-fever-nxDCVp3fLa

References (2)

Publisher
American Medical Association
Copyright
Copyright © 1944 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1944.02850170024004
Publisher site
See Article on Publisher Site

Abstract

At the present time rheumatic fever holds a prominent place in medical discussion and investigation. It is generally agreed that, although the nature of the disease is obscure, susceptibility of the host is the primary factor in the development of rheumatic fever. That this susceptibility is on an age and genetic basis is supported by considerable evidence.1 For more than fifty years there has been a widespread clinical impression that heredity is a significant factor in the observed concentration of rheumatic fever in certain families. This belief was based in large measure on the observed familial incidence of the disease. Recent family studies have been in accord with this observation.2 Since familial concentration is commonly observed in contagious, dietary and parasitic disorders, a disease may not be considered hereditary on the basis of a high familial incidence alone. Nonhereditary factors must be excluded, and the operation of hereditary

Journal

JAMAAmerican Medical Association

Published: Apr 22, 1944

There are no references for this article.