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Hereditary Hemorrhagic Telangiectasia and Factor VIII Deficiency

Hereditary Hemorrhagic Telangiectasia and Factor VIII Deficiency Abstract To the Editor. —In the article entitled "Hereditary Hemorrhagic Telangiectasia and Factor VIII Deficiency" in the August issue, Esham et al describe a patient with a case of severe hemorrhagic disorder. An important consideration, which the authors apparently failed to recognize, is that this patient may also have a circulating anticoagulant. This is suggested by the severity of the patient's bleeding tendency despite a factor VIII value of 28% and the development of an abnormal partial thromboplastin time after a bleeding episode that may represent an amnestic increase in the circulating anticoagulant level after therapeutic administration of factor VIII. The lack of response to plasma components containing factor VIII also suggest the presence of an inhibitor to factor VIII.Despite the authors' claim of presenting the first case of hereditary telangiectasia and factor VIII deficiency, Quick has previously described the cases of two patients with these defects.1 In these patients, References 1. Quick AJ: Bleeding Problems in Clinical Medicine . New York WB Saunders Co, 1970, pp 63-66. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Hereditary Hemorrhagic Telangiectasia and Factor VIII Deficiency

Hereditary Hemorrhagic Telangiectasia and Factor VIII Deficiency

Abstract

Abstract To the Editor. —In the article entitled "Hereditary Hemorrhagic Telangiectasia and Factor VIII Deficiency" in the August issue, Esham et al describe a patient with a case of severe hemorrhagic disorder. An important consideration, which the authors apparently failed to recognize, is that this patient may also have a circulating anticoagulant. This is suggested by the severity of the patient's bleeding tendency despite a factor VIII value of 28% and the...
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Publisher
American Medical Association
Copyright
Copyright © 1975 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1975.00330030140017
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor. —In the article entitled "Hereditary Hemorrhagic Telangiectasia and Factor VIII Deficiency" in the August issue, Esham et al describe a patient with a case of severe hemorrhagic disorder. An important consideration, which the authors apparently failed to recognize, is that this patient may also have a circulating anticoagulant. This is suggested by the severity of the patient's bleeding tendency despite a factor VIII value of 28% and the development of an abnormal partial thromboplastin time after a bleeding episode that may represent an amnestic increase in the circulating anticoagulant level after therapeutic administration of factor VIII. The lack of response to plasma components containing factor VIII also suggest the presence of an inhibitor to factor VIII.Despite the authors' claim of presenting the first case of hereditary telangiectasia and factor VIII deficiency, Quick has previously described the cases of two patients with these defects.1 In these patients, References 1. Quick AJ: Bleeding Problems in Clinical Medicine . New York WB Saunders Co, 1970, pp 63-66.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Mar 1, 1975

References