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HEREDITARY EDEMA OF THE LEGS (MILROY'S DISEASE): ASSOCIATED WITH OTHER CONGENITAL ANOMALIES

HEREDITARY EDEMA OF THE LEGS (MILROY'S DISEASE): ASSOCIATED WITH OTHER CONGENITAL ANOMALIES Abstract A case of hereditary edema of the legs with other congenital anomalies recently came under my observation. Hereditary edema of the legs being rare, its combination with other congenital anomalies warrants reporting this case as one of unusual interest. REPORT OF A CASE L. L., a white woman aged 28, was first seen at the Northwestern University Medical School on April 15, 1939. She stated that her limbs had been enlarged since infancy and that her mother and an aunt had the same condition. The enlargement appeared soon after her birth and gradually progressed during her growth and development. She had experienced no discomfort until about one and one-half years before her appearance at the clinic, when painful swelling of both feet developed, more evident during the afternoon and evening. Rest at night, however, did not materially reduce the swelling or relieve the pain. Properly fitted shoes were prescribed and References 1. Boks, D. B.: Congenital Familial Edema of the Lower Extremities , Nederl. tijdschr. v. geneesk. 1:416, 1913. 2. van Vliet, J. C.: Congenital Edema of the Lower Extremities in One Family , Nederl. tijdschr. v. geneesk. 2:1092, 1913. 3. Faber, H. K., and Lusignan, H. R.: Hereditary Elephantiasis , Am. J. Dis. Child. 46:816 ( (Oct.) ) 1933.Crossref 4. Milroy, F. W.: Chronic Hereditary Edema , J. A. M. A. 91:1172 ( (Oct. 20) ) 1928.Crossref 5. Meige, H.: Dystrophie oedémateuse héréditaire , Presse méd. 2:341, 1898. 6. Hope, W. B., and French, H.: Persistent Hereditary Oedema of the Legs , Quart. J. Med. 1:312, 1908. 7. Hamman, L.: Milroy's Disease , M. Clin. North America 1:182, 1917. 8. Brandt, G.: Ueber familiäre Elephantiasis cruris , Mitt. a. d. Grenzgeb. d. Med. u. Chir. 37:56, 1923. 9. Milroy, F. W.: An Undescribed Variety of Hereditary Edema , New York M. J. 56:505, 1892. 10. Hille, J.: Ueber die Elephantiasis, Wchnschr. f. d. ges. Heilk., 1841, pp. 433 and 457; cited by Brandt.8 11. Nonne, M.: Vier Fälle von Elephantiasis congenita hereditaria , Virchows Arch. f. path. Anat. 125:189, 1890.Crossref 12. Desnos: Oedeme rhumatismal chronique , Bull. et mém. Soc. méd. d. hôp. de Paris 3:65-73, 1891. 13. Griffith, J. P. C., and Newcomet, W. S.: Types of Oedema in Infancy and Childhood , Tr. A. Am. Physicians 12:399, 1897. 14. Weber, F. P., and Schlüter, A.: Nonne-Milroy-Meige Oedema, of Late Onset, in Sisters , Proc. Roy. Soc. Med. 30:933, 1937. 15. Lannois, M.: Une observation de trophœdème chronique héréditaire , Nouv. iconog. de la Salpêtrière 13:631, 1900 16. Hereditary Chronic Oedema of the Lower Limbs , M. Rev. 4:99, 1901. 17. Debove: Oedème segmentaire des membres inférieurs , Bull. et mém. Soc. méd. d. hôp. de Paris 14:1172, 1897. 18. Meige, H.: Le trophoedème chronique héréditaire , Nouv. iconog. de la Salpêtrière 12:453, 1899. 19. Rapin, E.: Sur une forme d'hypertrophie des membres , Nouv. iconog. de la Salpêtrière 14:472, 1901. 20. Valobra, I.: Les oedèmes circonscrits aigus et chroniques sous la dépendance du système nerveux (rôle de la sécrétion lymphatique dans leur pathogénie) , Nouv. iconog. de la Salpêtrière 18:201 and 255, 1905. 21. Spiller, cited by Ayala, G.: Le trophoedème chronique et le système endocrinosympathique , Encéphale 1:319, 1913. 22. Stoesser, A. V.: The Hypertrophies of Infancy and Childhood , Am. J. Dis. Child. 35:885 ( (May) ) 1928. 23. Sussini, M., and Casaubón, A.: Trofoedema crónico de Meige: Resultados quirúrgicos , Rev. de especialid. 1:474, 1926. 24. Elterich, T., and Yount, C. C.: Congenital Elephantiasis , Am. J. Dis. Child. 29:59 ( (Jan.) ) 1925. 25. McGuire, J., and Zeek, P.: Pathogenesis of Chronic Hereditary Edema of Extremities (Milroy's Disease) , J. A. M. A. 98:870 ( (March 12) ) 1932.Crossref 26. Homans, J.: The Treatment of Elephantiasis of the Legs , New England J. Med. 215:1099, 1936.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

HEREDITARY EDEMA OF THE LEGS (MILROY'S DISEASE): ASSOCIATED WITH OTHER CONGENITAL ANOMALIES

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Publisher
American Medical Association
Copyright
Copyright © 1940 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1940.01490180122010
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Abstract

Abstract A case of hereditary edema of the legs with other congenital anomalies recently came under my observation. Hereditary edema of the legs being rare, its combination with other congenital anomalies warrants reporting this case as one of unusual interest. REPORT OF A CASE L. L., a white woman aged 28, was first seen at the Northwestern University Medical School on April 15, 1939. She stated that her limbs had been enlarged since infancy and that her mother and an aunt had the same condition. The enlargement appeared soon after her birth and gradually progressed during her growth and development. She had experienced no discomfort until about one and one-half years before her appearance at the clinic, when painful swelling of both feet developed, more evident during the afternoon and evening. Rest at night, however, did not materially reduce the swelling or relieve the pain. Properly fitted shoes were prescribed and References 1. Boks, D. B.: Congenital Familial Edema of the Lower Extremities , Nederl. tijdschr. v. geneesk. 1:416, 1913. 2. van Vliet, J. C.: Congenital Edema of the Lower Extremities in One Family , Nederl. tijdschr. v. geneesk. 2:1092, 1913. 3. Faber, H. K., and Lusignan, H. R.: Hereditary Elephantiasis , Am. J. Dis. Child. 46:816 ( (Oct.) ) 1933.Crossref 4. Milroy, F. W.: Chronic Hereditary Edema , J. A. M. A. 91:1172 ( (Oct. 20) ) 1928.Crossref 5. Meige, H.: Dystrophie oedémateuse héréditaire , Presse méd. 2:341, 1898. 6. Hope, W. B., and French, H.: Persistent Hereditary Oedema of the Legs , Quart. J. Med. 1:312, 1908. 7. Hamman, L.: Milroy's Disease , M. Clin. North America 1:182, 1917. 8. Brandt, G.: Ueber familiäre Elephantiasis cruris , Mitt. a. d. Grenzgeb. d. Med. u. Chir. 37:56, 1923. 9. Milroy, F. W.: An Undescribed Variety of Hereditary Edema , New York M. J. 56:505, 1892. 10. Hille, J.: Ueber die Elephantiasis, Wchnschr. f. d. ges. Heilk., 1841, pp. 433 and 457; cited by Brandt.8 11. Nonne, M.: Vier Fälle von Elephantiasis congenita hereditaria , Virchows Arch. f. path. Anat. 125:189, 1890.Crossref 12. Desnos: Oedeme rhumatismal chronique , Bull. et mém. Soc. méd. d. hôp. de Paris 3:65-73, 1891. 13. Griffith, J. P. C., and Newcomet, W. S.: Types of Oedema in Infancy and Childhood , Tr. A. Am. Physicians 12:399, 1897. 14. Weber, F. P., and Schlüter, A.: Nonne-Milroy-Meige Oedema, of Late Onset, in Sisters , Proc. Roy. Soc. Med. 30:933, 1937. 15. Lannois, M.: Une observation de trophœdème chronique héréditaire , Nouv. iconog. de la Salpêtrière 13:631, 1900 16. Hereditary Chronic Oedema of the Lower Limbs , M. Rev. 4:99, 1901. 17. Debove: Oedème segmentaire des membres inférieurs , Bull. et mém. Soc. méd. d. hôp. de Paris 14:1172, 1897. 18. Meige, H.: Le trophoedème chronique héréditaire , Nouv. iconog. de la Salpêtrière 12:453, 1899. 19. Rapin, E.: Sur une forme d'hypertrophie des membres , Nouv. iconog. de la Salpêtrière 14:472, 1901. 20. Valobra, I.: Les oedèmes circonscrits aigus et chroniques sous la dépendance du système nerveux (rôle de la sécrétion lymphatique dans leur pathogénie) , Nouv. iconog. de la Salpêtrière 18:201 and 255, 1905. 21. Spiller, cited by Ayala, G.: Le trophoedème chronique et le système endocrinosympathique , Encéphale 1:319, 1913. 22. Stoesser, A. V.: The Hypertrophies of Infancy and Childhood , Am. J. Dis. Child. 35:885 ( (May) ) 1928. 23. Sussini, M., and Casaubón, A.: Trofoedema crónico de Meige: Resultados quirúrgicos , Rev. de especialid. 1:474, 1926. 24. Elterich, T., and Yount, C. C.: Congenital Elephantiasis , Am. J. Dis. Child. 29:59 ( (Jan.) ) 1925. 25. McGuire, J., and Zeek, P.: Pathogenesis of Chronic Hereditary Edema of Extremities (Milroy's Disease) , J. A. M. A. 98:870 ( (March 12) ) 1932.Crossref 26. Homans, J.: The Treatment of Elephantiasis of the Legs , New England J. Med. 215:1099, 1936.Crossref

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Dec 1, 1940

References