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Hercules and Hydra

Hercules and Hydra Abstract Research has three kinds of results: things, ideas, and heartbreak. Things include the discovery of new atomic particles, the synthesis of a new drug, and the determination of a new agent that is effective in treating or preventing a disease (eg, azidothymidine for the treatment of the acquired immunodeficiency syndrome). Results related to things are usually labor intensive, and expensive. Thing-related results are often evolutionary in nature, so a secondgeneration drug replaces the first-generation agent, or a social action replaces a treatment that has been successful for two centuries (eg, the elimination of smallpox vaccination). The heartbreaks of research are too painful to discuss further. New ideas often are not limited to a highly specific research setting and can have the profoundest impact. In a quest to understand the development of skin and alterations in epidermis in disease, we strayed far afield, and in a previous article in References 1. Goldsmith LA: Toads and psoriasis . Arch Dermatol 1986;122:939-940.Crossref 2. Graves R: The Greek Myths . New York, Penguin Books, 1955. 3. Wanek N, Nishimiya C, Achermann J, et al: Genetic analysis of developmental mechanisms in hydra: XIII. Identification of the cell lineages responsible for the reduced regenerative capacity in a mutant strain, reg-16 . Dev Biol 1986;115:459-468.Crossref 4. Kobatake E, Sugiyama T: Genetic analysis of developmental mechanisms in hydra: XVII. Elimination of excess epithelial cells by phagocytosis in a mutant strain, L4 . Dev Biol 1986;115:249-255.Crossref 5. Takano J, Sugiyama T: Genetic analysis of developmental mechanisms in hydra: XVI. Effect of food on budding and developmental gradients in a mutant strain, L4 . J Embryol Exp Morphol 1985;90:123-138. 6. Nishimiya C, Fujisawa T, Wanek N, et al: Genetic analysis of developmental mechanisms in hydra: XV. Nematocyte differentiation in strains with altered developmental gradients . Dev Growth Differ 1986;28:17-30.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1987.01660250125034
Publisher site
See Article on Publisher Site

Abstract

Abstract Research has three kinds of results: things, ideas, and heartbreak. Things include the discovery of new atomic particles, the synthesis of a new drug, and the determination of a new agent that is effective in treating or preventing a disease (eg, azidothymidine for the treatment of the acquired immunodeficiency syndrome). Results related to things are usually labor intensive, and expensive. Thing-related results are often evolutionary in nature, so a secondgeneration drug replaces the first-generation agent, or a social action replaces a treatment that has been successful for two centuries (eg, the elimination of smallpox vaccination). The heartbreaks of research are too painful to discuss further. New ideas often are not limited to a highly specific research setting and can have the profoundest impact. In a quest to understand the development of skin and alterations in epidermis in disease, we strayed far afield, and in a previous article in References 1. Goldsmith LA: Toads and psoriasis . Arch Dermatol 1986;122:939-940.Crossref 2. Graves R: The Greek Myths . New York, Penguin Books, 1955. 3. Wanek N, Nishimiya C, Achermann J, et al: Genetic analysis of developmental mechanisms in hydra: XIII. Identification of the cell lineages responsible for the reduced regenerative capacity in a mutant strain, reg-16 . Dev Biol 1986;115:459-468.Crossref 4. Kobatake E, Sugiyama T: Genetic analysis of developmental mechanisms in hydra: XVII. Elimination of excess epithelial cells by phagocytosis in a mutant strain, L4 . Dev Biol 1986;115:249-255.Crossref 5. Takano J, Sugiyama T: Genetic analysis of developmental mechanisms in hydra: XVI. Effect of food on budding and developmental gradients in a mutant strain, L4 . J Embryol Exp Morphol 1985;90:123-138. 6. Nishimiya C, Fujisawa T, Wanek N, et al: Genetic analysis of developmental mechanisms in hydra: XV. Nematocyte differentiation in strains with altered developmental gradients . Dev Growth Differ 1986;28:17-30.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Jan 1, 1987

References