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Hemorrhagic Peripheral Pigment Epithelial Disease

Hemorrhagic Peripheral Pigment Epithelial Disease Abstract • Hemorrhage under the retinal pigment epithelium and neurosensory retina occurred in the temporal periphery of ten patients with aging macular degeneration and one patient with histoplasmosis syndrome. The macula was not the source of bleeding. Peripheral subretinal neovascularization, commonly seen histopathologically, may be the cause. The visual recovery was poor, and most patients failed to regain lost vision once peripheral hemorrhage occurred. The differential diagnosis includes retinal detachment, uveal effusion, hemorrhagic retinoschisis, choroidal melanoma, and metastatic tumor. References 1. El Baba F, Jarrett W, Harbin T, et al: Massive hemorrhage complicating age-related macular degeneration . Ophthalmology 1986;93:1581-1592.Crossref 2. Wood WJ, Smith TR: Senile disciform macular degeneration complicated by massive hemorrhagic retinal detachment and angle closure glaucoma . Retina 1983;3:296-303.Crossref 3. Brown GC, Tasman WS, Shields JA: Massive subretinal hemorrhage and anticoagulant therapy . Can J Ophthalmol 1982;17:227-230. 4. Ferry AP: Lesions mistaken for malignant melanoma of the posterior uvea: A clinicopathologic analysis of 100 cases with ophthalmoscopically visible lesions . Arch Ophthalmol 1964;72:463-469.Crossref 5. Shields JA, Zimmerman LE: Lesions simulating malignant melanoma of the posterior uvea . Arch Ophthalmol 1973;89:466-471.Crossref 6. Howard GM: Erroneous clinical diagnoses of retinoblastoma and uveal melanoma . Trans Am Acad Ophthalmol Otolaryngol 1969;73:199-203. 7. Robertson DM, Campbell RJ: Errors in the diagnosis of malignant melanoma of the choroid . Am J Ophthalmol 1979;87:269-275. 8. Shields JA, Augsburger JJ, Brown GC, et al: The differential diagnosis of posterior uveal melanoma . Ophthalmology 1980;87:518-522.Crossref 9. Davidorf FH, Letson AD, Weiss ET, et al: Incidence of misdiagnosed and unsuspected choroidal melanomas: A 50-year experience . Arch Ophthalmol 1983;101:410-412.Crossref 10. Green W, Wilson D: Choroidal neovascularization . Ophthalmology 1986;93:1169-1176.Crossref 11. Friedman E, Smith T, Kuwabara T: Senile choroidal vascular patterns and drusen . Arch Ophthalmol 1963;69:220-230.Crossref 12. Sarks S: New vessel formation beneath the retinal pigment epithelium in senile eyes . Br J Ophthalmol 1973;57:951-965.Crossref 13. Foos R, Trese M: Chorioretinal juncture . Arch Ophthalmol 1982;100:1492-1503.Crossref 14. Silva V, Brockhurst R: Hemorrhagic detachment of the peripheral retinal pigment epithelium . Arch Ophthalmol 1976;94:1295-1300.Crossref 15. Eagle R: Mechanisms of maculopathy . Ophthalmology 1984;91:613-625.Crossref 16. Glaser BM, Campochiaro PA, Davis JL, et al: Retinal pigment epithelial cells release an inhibitor of neovascularization . Arch Ophthalmol 1985;103:1870-1875.Crossref 17. Swanson D, Kalina R, Guzak S: Tears of the retinal pigment epithelium . Retina 1984;4:115-118.Crossref 18. Traboulsi EI, Jalkh AE: Retinal pigment epithelium tear as a cause of vitreous hemorrhage . Ann Ophthalmol 1985;17:228-235. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1988 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1988.01060130700028
Publisher site
See Article on Publisher Site

Abstract

Abstract • Hemorrhage under the retinal pigment epithelium and neurosensory retina occurred in the temporal periphery of ten patients with aging macular degeneration and one patient with histoplasmosis syndrome. The macula was not the source of bleeding. Peripheral subretinal neovascularization, commonly seen histopathologically, may be the cause. The visual recovery was poor, and most patients failed to regain lost vision once peripheral hemorrhage occurred. The differential diagnosis includes retinal detachment, uveal effusion, hemorrhagic retinoschisis, choroidal melanoma, and metastatic tumor. References 1. El Baba F, Jarrett W, Harbin T, et al: Massive hemorrhage complicating age-related macular degeneration . Ophthalmology 1986;93:1581-1592.Crossref 2. Wood WJ, Smith TR: Senile disciform macular degeneration complicated by massive hemorrhagic retinal detachment and angle closure glaucoma . Retina 1983;3:296-303.Crossref 3. Brown GC, Tasman WS, Shields JA: Massive subretinal hemorrhage and anticoagulant therapy . Can J Ophthalmol 1982;17:227-230. 4. Ferry AP: Lesions mistaken for malignant melanoma of the posterior uvea: A clinicopathologic analysis of 100 cases with ophthalmoscopically visible lesions . Arch Ophthalmol 1964;72:463-469.Crossref 5. Shields JA, Zimmerman LE: Lesions simulating malignant melanoma of the posterior uvea . Arch Ophthalmol 1973;89:466-471.Crossref 6. Howard GM: Erroneous clinical diagnoses of retinoblastoma and uveal melanoma . Trans Am Acad Ophthalmol Otolaryngol 1969;73:199-203. 7. Robertson DM, Campbell RJ: Errors in the diagnosis of malignant melanoma of the choroid . Am J Ophthalmol 1979;87:269-275. 8. Shields JA, Augsburger JJ, Brown GC, et al: The differential diagnosis of posterior uveal melanoma . Ophthalmology 1980;87:518-522.Crossref 9. Davidorf FH, Letson AD, Weiss ET, et al: Incidence of misdiagnosed and unsuspected choroidal melanomas: A 50-year experience . Arch Ophthalmol 1983;101:410-412.Crossref 10. Green W, Wilson D: Choroidal neovascularization . Ophthalmology 1986;93:1169-1176.Crossref 11. Friedman E, Smith T, Kuwabara T: Senile choroidal vascular patterns and drusen . Arch Ophthalmol 1963;69:220-230.Crossref 12. Sarks S: New vessel formation beneath the retinal pigment epithelium in senile eyes . Br J Ophthalmol 1973;57:951-965.Crossref 13. Foos R, Trese M: Chorioretinal juncture . Arch Ophthalmol 1982;100:1492-1503.Crossref 14. Silva V, Brockhurst R: Hemorrhagic detachment of the peripheral retinal pigment epithelium . Arch Ophthalmol 1976;94:1295-1300.Crossref 15. Eagle R: Mechanisms of maculopathy . Ophthalmology 1984;91:613-625.Crossref 16. Glaser BM, Campochiaro PA, Davis JL, et al: Retinal pigment epithelial cells release an inhibitor of neovascularization . Arch Ophthalmol 1985;103:1870-1875.Crossref 17. Swanson D, Kalina R, Guzak S: Tears of the retinal pigment epithelium . Retina 1984;4:115-118.Crossref 18. Traboulsi EI, Jalkh AE: Retinal pigment epithelium tear as a cause of vitreous hemorrhage . Ann Ophthalmol 1985;17:228-235.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: May 1, 1988

References