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Hemorrhagic Darier's Disease

Hemorrhagic Darier's Disease Abstract To the Editor.— While examining 34 individuals with Darier's disease from three large pedigrees in the southern tier of New York State, we found five individuals, all from one pedigree (DD-He) who had hemorrhagic bullae and red and black macules with jagged borders on the hands and feet (Figs 1 and 2). The lesions developed after trauma and would resolve after several weeks. There was no history of hemorrhagic lesions in anyone in the kindred who did not have Darier's disease. The age of onset of Darier's disease was no different for individuals with or without hemorrhagic lesions. Some members of pedigree DD-He had been reported previously by Beck et al.1Hemorrhagic Darier's disease was first described in 1964 by Jones et al2 in four patients with Darier's disease, two of whom were a mother and daughter. Biopsy specimens from these patients showed intraepidermal lacunae filled with red References 1. Beck AL, Finocchio AF, White JP. Darier's disease: a kindred with a large number of cases . Br J Dermatol. 1977;97:335-339.Crossref 2. Jones WN, Nix TE, Clark WH. Hemorrhagic Darier's disease . Arch Dermatol. 1964;89:523-527.Crossref 3. Coulson IH, Misch KJ. Hemorrhagic Darier's disease . J R Soc Med. 1989; 82:365-366. 4. Gebauer K, Holgate C, Navaratnam A. Retinoid-induced haemorrhagic bullae in Darier's disease . Australas J Dermatol. 1990;31:99-103.Crossref 5. Burge SM, Wilkinson JD. Darier-White disease: a review of the clinical features in 163 patients . J Am Acad Dermatol. 1992;27:40-50.Crossref 6. Munro CS. The phenotype of Darier's disease: penetrance and expressivity in adults and children . Br J Dermatol. 1992;127:126-130.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1993 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1993.01680250127024
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— While examining 34 individuals with Darier's disease from three large pedigrees in the southern tier of New York State, we found five individuals, all from one pedigree (DD-He) who had hemorrhagic bullae and red and black macules with jagged borders on the hands and feet (Figs 1 and 2). The lesions developed after trauma and would resolve after several weeks. There was no history of hemorrhagic lesions in anyone in the kindred who did not have Darier's disease. The age of onset of Darier's disease was no different for individuals with or without hemorrhagic lesions. Some members of pedigree DD-He had been reported previously by Beck et al.1Hemorrhagic Darier's disease was first described in 1964 by Jones et al2 in four patients with Darier's disease, two of whom were a mother and daughter. Biopsy specimens from these patients showed intraepidermal lacunae filled with red References 1. Beck AL, Finocchio AF, White JP. Darier's disease: a kindred with a large number of cases . Br J Dermatol. 1977;97:335-339.Crossref 2. Jones WN, Nix TE, Clark WH. Hemorrhagic Darier's disease . Arch Dermatol. 1964;89:523-527.Crossref 3. Coulson IH, Misch KJ. Hemorrhagic Darier's disease . J R Soc Med. 1989; 82:365-366. 4. Gebauer K, Holgate C, Navaratnam A. Retinoid-induced haemorrhagic bullae in Darier's disease . Australas J Dermatol. 1990;31:99-103.Crossref 5. Burge SM, Wilkinson JD. Darier-White disease: a review of the clinical features in 163 patients . J Am Acad Dermatol. 1992;27:40-50.Crossref 6. Munro CS. The phenotype of Darier's disease: penetrance and expressivity in adults and children . Br J Dermatol. 1992;127:126-130.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Apr 1, 1993

References