Access the full text.
Sign up today, get DeepDyve free for 14 days.
E. Payne, E. Sharp, Jose Knaudt (1948)
Treatment of epidemic typhus with chloromycetin.The Journal of tropical medicine and hygiene, 51 4
J. Smadel, T. Woodward, C. Bailey (1949)
Relation of relapses in typhoid to duration of chloramphenicol therapy.Journal of the American Medical Association, 141 2
J. Ehrlich, Q. Bartz, R. Smith, D. Joslyn, P. Burkholder (1947)
Chloromycetin, a New Antibiotic From a Soil Actinomycete.Science, 106 2757
Theodore Woodward, J. Smadel, Herbert Ley, Richard Green, D. Mankikar (2004)
Excerpts from: Preliminary Report on the Beneficial Effect of Chloromycetin in the Treatment of Typhoid FeverWilderness & Environmental Medicine, 15
W. Bradley (1949)
Chloromycetin in typhoid fever.Lancet, 1 6560
A. Rosenblum (1949)
Typhoid and paratyphoid fever in immunized subjects.Annals of internal medicine, 31 2
R. Gauld, A. Schlingman, E. Jackson, M. Manning, H. Batson, C. Campbell (1949)
CHLORAMPHENICOL (CHLOROMYCETIN) IN EXPERIMENTAL CHOLERA INFECTIONSJournal of Bacteriology, 57
H. Ley, J. Smadel, T. Crocker (1948)
Administration of Chloromycetin to Normal Human SubjectsProceedings of the Society for Experimental Biology and Medicine, 68
Robert Smith, Dwight, A. Joslyn, O. Gruhzit, I., William, McLEAN, M. Penner (1948)
Chloromycetin: Biological StudiesJournal of Bacteriology, 55
Profound hemopoietic changes have been observed in patients who have received chloramphenicol (chloromycetin®) therapy. Streptomyces venezuelae, from which the agent is derived, was isolated and its antibiotic activity demonstrated by Burkholder and others in 1947.1 In the same year, Ehrlich and his co-workers1 extended the studies and prepared the compound in crystalline form. Payne and collaborators2 first employed the drug clinically in typhus fever in 1948. Chloramphenicol is well absorbed from the gastro-intestinal tract, blood levels after oral ingestion of the drug begin comparable to those obtained by parenteral administration.3 It is excreted largely in the urine, appreciable amounts being found within one-half hour after a single oral dose, and maximal urinary concentrations occur between two and eight hours. Eighty to 92 per cent of the total amount administered is excreted within twenty-four hours.1 In the experiments of Smith and his associates4 varying
JAMA – American Medical Association
Published: Apr 29, 1950
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.