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P. Ostrow, E. Moxon, N. Vernon, R. Kapko (1979)
Pathogenesis of bacterial meningitis. Studies on the route of meningeal invasion following Hemophilus influenzae inoculation of infant rats.Laboratory investigation; a journal of technical methods and pathology, 40 6
(1982)
Prevention of secondary cases of Haemophilus influenzae type b diseaseMMWR, 31
W. Johanson, W. Johanson, D. Woods, D. Woods, T. Chaudhuri, T. Chaudhuri (1979)
Association of respiratory tract colonization with adherence of gram-negative bacilli to epithelial cells.The Journal of infectious diseases, 139 6
E. Moxon, Arnold Smith, Damon Averill, David Smith (1974)
Haemophilus influenzae meningitis in infant rats after intranasal inoculation.The Journal of infectious diseases, 129 2
G. Greene (1978)
Meningitis due to Haemophilus influenzae other than type b: case report and review.Pediatrics, 62 6
V. Joaquin, G. Altshuler, W. Robinson, M. Marks, A. Weber (1983)
Haemophilus influenzae b bacteremia and meningitis in infant rabbits after intranasal inoculation.The Journal of laboratory and clinical medicine, 102 6
Yasutaka Sakata, Antonio Boccazzi, G. McCracken (1983)
Pharmacokinetics and bacteriological effect of ceftazidime in experimental Streptococcus pneumoniae, Haemophilus influenzae, and Escherichia coli meningitisAntimicrobial Agents and Chemotherapy, 23
Ziegler EJ Marks MI (1982)
Lethal Haemophilus influenzae type b infection in miceInfection, 10
R. Schneerson, J. Robbins (1971)
Age-Related Susceptibility to Haemophilus influenzae Type b Disease in RabbitsInfection and Immunity, 4
Altshuler GP Joaquin VH (1983)
Haemophilus influenzae b bacteremia and meningitis in infant rabbits following intranasal inoculationJ Lab Clin Med, 102
M. Loeb, D. Smith (1980)
Outer membrane protein composition in disease isolates of Haemophilus influenzae: pathogenic and epidemiological implications.Infection and immunity, 30 3
P. Weller, A. Smith, P. Anderson, D. Smith (1977)
The role of encapsulation and host age in the clearance of Haemophilus influenzae bacteremia.The Journal of infectious diseases, 135 1
R. Williams, R. Gibbons (1975)
Inhibition of streptococcal attachment to receptors on human buccal epithelial cells by antigenically similar salivary glycoproteinsInfection and Immunity, 11
(1979)
Bacterial meningitis and meningococcemia—United States 1978MMWR, 28
S. Barenkamp, S. Barenkamp, R. Munson, R. Munson, D. Granoff, D. Granoff (1981)
Subtyping isolates of Haemophilus influenzae type b by outer-membrane protein profiles.The Journal of infectious diseases, 143 5
Leitz MA Swabb EA (1981)
Pharmacokinetics of the monobactam SQ26776 after single intravenous doses in healthy subjectsJ Antimicrob Chemother, 8
W. Kobasa, D. Kaye (1983)
Aztreonam, cefoperazone, and gentamicin in the treatment of experimental Enterobacter aerogenes endocarditis in rabbitsAntimicrobial Agents and Chemotherapy, 24
E. Moxon, Karen Vaughn (1981)
The type b capsular polysaccharide as a virulence determinant of Haemophilus influenzae: studies using clinical isolates and laboratory transformants.The Journal of infectious diseases, 143 4
E. Beachey, E. Beachey (1981)
Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface.The Journal of infectious diseases, 143 3
Sarah Sell, Robert Merrill, E. Doyne, E. Zimsky (1972)
Long-term sequelae of Hemophilus influenzae meningitis.Pediatrics, 49 2
Abstract • A model of human Hemophilus influenzae type b meningitis was developed in infant rabbits infected intranasally. The pathogenesis and course resembled that in human beings; bacteremia was followed by meningitis with a high mortality. Pretreatment of the nasopharyngeal mucosa with 0.5% trypsin or normal saline significantly increased the rate of bacteremia. Death was age related. Intranasal challenge with type f and nontypeable H influenzae was associated with transient bacteremia. Our results suggest that factors on the respiratory tract epithelial cell surface influence colonization and infection with H influenzae type b and confirm the importance of other host and parasite factors. Intravenous aztreonam resulted in a peak CSF concentration that was 6% to 7% of the serum concentration in infected meninges but only 2% to 3% in normal meninges. Aztreonam reduced mortality in established H influenzae type b meningitis from 88% in untreated animals to 9%. (AJDC 1984;138:455-458) References 1. Prevention of secondary cases of Haemophilus influenzae type b disease . MMWR 1982; 31:672-680. 2. Sell SHW, Merrill RE, Doyne EO, et al: Long-term sequelae of Haemophilus influenzae meningitis . Pediatrics 1972;49:206-211. 3. San Joaquin VH, Altshuler GP, Robinson W, et al: Haemophilus influenzae b bacteremia and meningitis in infant rabbits following intranasal inoculation . J Lab Clin Med 1983;102:939-946. 4. Marks MI, Ziegler EJ, Douglas H, et al: Lethal Haemophilus influenzae type b infection in mice . Infection 1982;10:261-266.Crossref 5. Swabb EA, Leitz MA, Piekiewicz FG, et al: Pharmacokinetics of the monobactam SQ26776 after single intravenous doses in healthy subjects . J Antimicrob Chemother 1981;8:131-140.Crossref 6. Ostrow PT, Moxon ER, Vernon N, et al: Pathogenesis of bacterial meningitis: Studies of the route of meningeal invasion following Haemophilus influenzae inoculation of infant rats . Lab Invest 1979;40:678-685. 7. Moxon ER, Smith AL, Averill DR, et al: Haemophilus influenzae meningitis in infant rats after intranasal inoculation . J Infect Dis 1974;129:154-162.Crossref 8. Bacterial meningitis and meningococcemia—United States 1978 . MMWR 1979;28: 277-279. 9. Schneerson R, Robbins JB: Age-related susceptibility to Haemophilus influenzae type b disease in rabbits . Infect Immun 1971;4:397-401. 10. Greene GR: Meningitis due to Haemophilus influenzae other than type b: Case report and review . Pediatrics 1978;62:1021-1025. 11. Weller PF, Smith AL, Anderson P, et al: The role of encapsulation and host age in the clearance of Haemophilus influenzae bacteremia . J Infect Dis 1977;135:34-41.Crossref 12. Moxon ER, Vaughn KA: The type b capsular polysaccharide as a virulence determinant of Haemophilus influenzae: Studies using clinical isolates and laboratory transformants . J Infect Dis 1981;143:517-524.Crossref 13. Loeb MR, Smith DH: Outer membrane protein composition in disease isolates of Haemophilus influenzae: Pathogenic and epidemiological implications . Infect Immun 1980;30: 709-717. 14. Barenkamp SJ, Munson RS Jr, Granoff DM: Subtyping isolates of Haemophilus influenzae type b by outer-membrane protein profiles . J Infect Dis 1981;143:668-676.Crossref 15. Beachey EH: Bacterial adherence: Adhesin-receptor interactions mediating the attachment of bacteria to mucosal surfaces . J Infect Dis 1981;143:325-345.Crossref 16. Johanson WG Jr, Woods DE, Chaudhuri T: Association of respiratory tract colonization with adherence of gram-negative bacilli to epithelial cells . J Infect Dis 1979;139:667-673.Crossref 17. Williams RC, Gibbons RJ: Inhibition of streptococcal attachment to receptors on human buccal epithelium by antigenically similar salivary glycoproteins . Infect Immun 1975;11: 711-718. 18. Sakata Y, Boccazzi A, McCracken GH Jr: Pharmacokinetics and bacteriological effect of ceftazidime in experimental Streptococcus pneumoniae, Haemophilus influenzae, and Escherichia coli meningitis . Antimicrob Agents Chemother 1983;23:213-217.Crossref 19. Scheld WM, Brodeur JP: Comparative activity of aztreonam in experimental meningitis, abstract 135. Program and abstracts of the 22nd Interscience Conference on Antimicrobial Agents and Chemotherapy, Miami Beach, Oct 4-6, 1982. 20. Kobasa WD, Kaye D: Aztreonam, cefoperazone, and gentamicin in the treatment of experimental Enterobacter aerogenes endocarditis in rabbits . Antimicrob Agents Chemother 1983;24:321-324.Crossref
American Journal of Diseases of Children – American Medical Association
Published: May 1, 1984
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