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Hemolytic Uremic Syndrome After Campylobacter-Induced Diarrhea in an Adult

Hemolytic Uremic Syndrome After Campylobacter-Induced Diarrhea in an Adult Abstract • Campylobacter fetus subspecies jejuni is a recognized pathogen of the gastrointestinal (GI) tract resulting in a spectrum of illness from mild gastroenteritis to severe colitis with bloody diarrhea. Campylobacter is also being recognized as capable of producing systemic illness. Furthermore, antibody response, hypocomplementemia, and bacteremia with enterotoxic organisms have been described. Many of the clinical features, both local (ie, in the GI tract) and systemic, parallel those of Shigella. Since the hemolytic uremic syndrome (HUS) may be produced by the effect of endotoxins or the immunocomplex on vascular endothelium in susceptible patients, it is expected that this syndrome may follow Campylobacter enteritis as it does Shigella enteritis. We, therefore, believe Campylobacter jejuni enteritis should be considered as one of the causative agents capable of inducing the HUS. (Arch Intern Med 1984;144:1074-1076) References 1. Gasser C, Gautier E, Steck A, et al: Hämolytisch-urämische Syndrome: Bilaterale Nierenrindensekrosen bei akuten erwerbenen hämolytischen Anämen. Schweiz Med Wochenschr 1955;85:905-909. 2. Hauglustaine D, Van Damme B, Vansenleighens Y, et al: Recurrent hemolytic uremic syndrome during oral contraception. Clin Nephrol 1981;15:148-153. 3. Remuzze G, Marchen R, Mecca G, et al: Haemolytic-uremic syndrome: Deficiency of plasma factors regulating prostacyclin activity. Lancet 1978;2:871-872.Crossref 4. Leithner C, Senzinger H, Phanker F, et al: Recurrence of haemolytic uremic syndrome triggered by cyclosporin A after renal transplantation. Lancet 1982;1:1470.Crossref 5. Ray CG, Tucker VI, Harris D, et al: Enterovirus associated with the hemolytic uremic syndrome. Pediatrics 1970;46:378-387. 6. Koster F, Levine J, Walker L, et al: Hemolytic uremic syndrome after shigellosis: Relation to endotoxemia and circulating immune complexes. N Engl J Med 1978;298:927-933.Crossref 7. Rapaport SE, Taller D, Coeren Barrow N, et al: Pseudemonas septicemia with intravascular clotting leading to the generalized Shwartzman reaction. N Engl J Med 1964;271:80-84.Crossref 8. Denneberg T, Friedberg M, Holmberg L, et al: Combined plasmapheresis and hemodialysis treatment for severe hemolytic uremic syndrome following Campylobacter colitis. Acta Paediatr Scand 1982;71:743-745.Crossref 9. Marel-Maroger L: Adult hemolytic uremic syndrome. Kidney Int 1980;18:125-134.Crossref 10. Whitington P, Friedman A, Chesney R: Gastrointestinal disease in the hemolytic uremic syndrome. Gastroenterology 1979;76:728-733. 11. Brain MC, Dacie JV, Hourishav D: Microangiopathic haemolytic anemia: The possible role of vascular lesions in pathogenesis. Br J Haematol 1962;8:358-374.Crossref 12. Thomas L, Goed RA: Studies on the generalized Shwartzman reactions: General observation concerning the phenomenon. J Exp Med 1952; 96:605-624.Crossref 13. Goyner E, Bouvier C, Spaet TH: Vascular lesions, possible pathogenic basis of the generalized Shwartzman reaction. Science 1970;170: 986-988.Crossref 14. McCoy RC, Abramosky CR, Krueger R: The hemolytic uremic syndrome with positive immunofluorescence studies. J Pediatr 1974;85: 170-174.Crossref 15. Kim Y, Millen K, Michael AF: Breakdown products of C3 and factor B in hemolytic uremic syndrome. J Lab Clin Med 1977;89:845-850. 16. Kaplan BS, Thomson PD, Maeno GM: Serum complement levels in the haemolytic uremic syndrome. Lancet 1973;2:1505-1506.Crossref 17. Stuhlinger W, Kourilsky O, Kanfer A, et al: Haemolytic uremic syndrome evidence of intravascular C3 activation. Lancet 1974;2:788-789.Crossref 18. Bergstein JM, Kuedeili V, Bang N: Plasma inhibitors of glomerular fibrinolysis in the hemolytic uremic syndrome. Am J Med 1982;73:322-327.Crossref 19. Webster J, Reese AJ, Lewis PJ, et al: Prostacyclin deficiency in haemolytic uremic syndrome. Br Med J 1980;281:271.Crossref 20. Blaser M, Parsons R, Wang WL: Acute colitis caused by Campylobacter fetus ss jejuni. Gastroenterology 1980;78:448-453. 21. Arrayo J, Lystem S: Hypocomplementemia and Campylobacter fetus infection. South Med J 1980;73:1540-1542.Crossref 22. Guenant RL, Labila RG, Winn WC, et al: Campylobacterosis in man: Pathogenic mechanisms and review of 91 bloodstream infections. Am J Med 1978;65:584-592.Crossref 23. Butzler JP, Skurow MB: Campylobacter enteritis. Clin Gastroenterol 1979;18:737-765. 24. Urman JD, Zuerier RB, Rothfield NF: Reiter's syndrome associated with Campylobacter fetus infection. Ann Intern Med 1977;86:444-445.Crossref 25. Berden JHM, Muytjens HZ, Varde Pulte LBA: Reactions arthritis associated with Campylobacter jejuni enteritis. Br Med J 1979;1:380-381.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Hemolytic Uremic Syndrome After Campylobacter-Induced Diarrhea in an Adult

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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1984.00350170242039
Publisher site
See Article on Publisher Site

Abstract

Abstract • Campylobacter fetus subspecies jejuni is a recognized pathogen of the gastrointestinal (GI) tract resulting in a spectrum of illness from mild gastroenteritis to severe colitis with bloody diarrhea. Campylobacter is also being recognized as capable of producing systemic illness. Furthermore, antibody response, hypocomplementemia, and bacteremia with enterotoxic organisms have been described. Many of the clinical features, both local (ie, in the GI tract) and systemic, parallel those of Shigella. Since the hemolytic uremic syndrome (HUS) may be produced by the effect of endotoxins or the immunocomplex on vascular endothelium in susceptible patients, it is expected that this syndrome may follow Campylobacter enteritis as it does Shigella enteritis. We, therefore, believe Campylobacter jejuni enteritis should be considered as one of the causative agents capable of inducing the HUS. (Arch Intern Med 1984;144:1074-1076) References 1. Gasser C, Gautier E, Steck A, et al: Hämolytisch-urämische Syndrome: Bilaterale Nierenrindensekrosen bei akuten erwerbenen hämolytischen Anämen. Schweiz Med Wochenschr 1955;85:905-909. 2. Hauglustaine D, Van Damme B, Vansenleighens Y, et al: Recurrent hemolytic uremic syndrome during oral contraception. Clin Nephrol 1981;15:148-153. 3. Remuzze G, Marchen R, Mecca G, et al: Haemolytic-uremic syndrome: Deficiency of plasma factors regulating prostacyclin activity. Lancet 1978;2:871-872.Crossref 4. Leithner C, Senzinger H, Phanker F, et al: Recurrence of haemolytic uremic syndrome triggered by cyclosporin A after renal transplantation. Lancet 1982;1:1470.Crossref 5. Ray CG, Tucker VI, Harris D, et al: Enterovirus associated with the hemolytic uremic syndrome. Pediatrics 1970;46:378-387. 6. Koster F, Levine J, Walker L, et al: Hemolytic uremic syndrome after shigellosis: Relation to endotoxemia and circulating immune complexes. N Engl J Med 1978;298:927-933.Crossref 7. Rapaport SE, Taller D, Coeren Barrow N, et al: Pseudemonas septicemia with intravascular clotting leading to the generalized Shwartzman reaction. N Engl J Med 1964;271:80-84.Crossref 8. Denneberg T, Friedberg M, Holmberg L, et al: Combined plasmapheresis and hemodialysis treatment for severe hemolytic uremic syndrome following Campylobacter colitis. Acta Paediatr Scand 1982;71:743-745.Crossref 9. Marel-Maroger L: Adult hemolytic uremic syndrome. Kidney Int 1980;18:125-134.Crossref 10. Whitington P, Friedman A, Chesney R: Gastrointestinal disease in the hemolytic uremic syndrome. Gastroenterology 1979;76:728-733. 11. Brain MC, Dacie JV, Hourishav D: Microangiopathic haemolytic anemia: The possible role of vascular lesions in pathogenesis. Br J Haematol 1962;8:358-374.Crossref 12. Thomas L, Goed RA: Studies on the generalized Shwartzman reactions: General observation concerning the phenomenon. J Exp Med 1952; 96:605-624.Crossref 13. Goyner E, Bouvier C, Spaet TH: Vascular lesions, possible pathogenic basis of the generalized Shwartzman reaction. Science 1970;170: 986-988.Crossref 14. McCoy RC, Abramosky CR, Krueger R: The hemolytic uremic syndrome with positive immunofluorescence studies. J Pediatr 1974;85: 170-174.Crossref 15. Kim Y, Millen K, Michael AF: Breakdown products of C3 and factor B in hemolytic uremic syndrome. J Lab Clin Med 1977;89:845-850. 16. Kaplan BS, Thomson PD, Maeno GM: Serum complement levels in the haemolytic uremic syndrome. Lancet 1973;2:1505-1506.Crossref 17. Stuhlinger W, Kourilsky O, Kanfer A, et al: Haemolytic uremic syndrome evidence of intravascular C3 activation. Lancet 1974;2:788-789.Crossref 18. Bergstein JM, Kuedeili V, Bang N: Plasma inhibitors of glomerular fibrinolysis in the hemolytic uremic syndrome. Am J Med 1982;73:322-327.Crossref 19. Webster J, Reese AJ, Lewis PJ, et al: Prostacyclin deficiency in haemolytic uremic syndrome. Br Med J 1980;281:271.Crossref 20. Blaser M, Parsons R, Wang WL: Acute colitis caused by Campylobacter fetus ss jejuni. Gastroenterology 1980;78:448-453. 21. Arrayo J, Lystem S: Hypocomplementemia and Campylobacter fetus infection. South Med J 1980;73:1540-1542.Crossref 22. Guenant RL, Labila RG, Winn WC, et al: Campylobacterosis in man: Pathogenic mechanisms and review of 91 bloodstream infections. Am J Med 1978;65:584-592.Crossref 23. Butzler JP, Skurow MB: Campylobacter enteritis. Clin Gastroenterol 1979;18:737-765. 24. Urman JD, Zuerier RB, Rothfield NF: Reiter's syndrome associated with Campylobacter fetus infection. Ann Intern Med 1977;86:444-445.Crossref 25. Berden JHM, Muytjens HZ, Varde Pulte LBA: Reactions arthritis associated with Campylobacter jejuni enteritis. Br Med J 1979;1:380-381.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: May 1, 1984

References