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Hemolytic Complement Activity in Aqueous Humor

Hemolytic Complement Activity in Aqueous Humor Abstract • Hemolytic C1, C4, C3, and C5 and IgG levels were measured in aqueous humor obtained at surgery from human eyes without inflammation or previous surgery (group 1), eyes with previous surgery (group 2), and eyes with anterior uveitis (group 3). Serum hemolytic complement and IgG levels were also compared with aqueous humor levels. Aqueous humor from eyes in group 1 contained functional C1, C4, C3, and C5, but there was relatively little complement in normal aqueous humor when compared with serum. The mean values of all complement components and IgG in aqueous humor increased from groups 1 to 3; aqueous-serum ratios for each complement component and IgG also increased from groups 1 to 3. Eyes in group 3 had the highest complement and IgG levels and in some cases these values approached those found in serum. References 1. Chandler JW, Leder R, Kaufman HE, et al: Quantitative determinations of complement components and immunoglobulins in tears and aqueous humor . Invest Ophthalmol Vis Sci 1974;13:151-153. 2. Boros T, Rapp HJ: Immune hemolysis: A simplified method for the preparation of EAC'4 with guinea pig or with human complement . J Immunol 1967;9:263-268. 3. Mondino BJ, Hoffman DB: Hemolytic complement activity in normal human donor corneas . Arch Ophthalmol 1980;98:2041-2044.Crossref 4. Zar JH: Biostatistical Analysis . Englewood Cliffs, NJ, Prentice-Hall Inc, 1974, pp 133-142. 5. Kruskal WH, Wallis WA: Use of ranks in one-criterion analysis of variance . J Am Statist Assoc 1952;47:583-621.Crossref 6. Dunn OJ: Multiple comparisons using rank sums . Technometrics 1964;6:241-252.Crossref 7. Natvig JB, Winchester RJ: Complement in rheumatoid inflammation . Acta Rheum Scand 1969;15:161-168. 8. Allansmith MR, Whitney CR, McClellan BH, et al: Immunoglobulins in the human eye . Arch Ophthalmol 1973;89:36-45.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Hemolytic Complement Activity in Aqueous Humor

Archives of Ophthalmology , Volume 101 (3) – Mar 1, 1983

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Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1983.01040010465028
Publisher site
See Article on Publisher Site

Abstract

Abstract • Hemolytic C1, C4, C3, and C5 and IgG levels were measured in aqueous humor obtained at surgery from human eyes without inflammation or previous surgery (group 1), eyes with previous surgery (group 2), and eyes with anterior uveitis (group 3). Serum hemolytic complement and IgG levels were also compared with aqueous humor levels. Aqueous humor from eyes in group 1 contained functional C1, C4, C3, and C5, but there was relatively little complement in normal aqueous humor when compared with serum. The mean values of all complement components and IgG in aqueous humor increased from groups 1 to 3; aqueous-serum ratios for each complement component and IgG also increased from groups 1 to 3. Eyes in group 3 had the highest complement and IgG levels and in some cases these values approached those found in serum. References 1. Chandler JW, Leder R, Kaufman HE, et al: Quantitative determinations of complement components and immunoglobulins in tears and aqueous humor . Invest Ophthalmol Vis Sci 1974;13:151-153. 2. Boros T, Rapp HJ: Immune hemolysis: A simplified method for the preparation of EAC'4 with guinea pig or with human complement . J Immunol 1967;9:263-268. 3. Mondino BJ, Hoffman DB: Hemolytic complement activity in normal human donor corneas . Arch Ophthalmol 1980;98:2041-2044.Crossref 4. Zar JH: Biostatistical Analysis . Englewood Cliffs, NJ, Prentice-Hall Inc, 1974, pp 133-142. 5. Kruskal WH, Wallis WA: Use of ranks in one-criterion analysis of variance . J Am Statist Assoc 1952;47:583-621.Crossref 6. Dunn OJ: Multiple comparisons using rank sums . Technometrics 1964;6:241-252.Crossref 7. Natvig JB, Winchester RJ: Complement in rheumatoid inflammation . Acta Rheum Scand 1969;15:161-168. 8. Allansmith MR, Whitney CR, McClellan BH, et al: Immunoglobulins in the human eye . Arch Ophthalmol 1973;89:36-45.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Mar 1, 1983

References