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Hemolytic Anemia With Mycoplasma Pneumoniae Pneumonia

Hemolytic Anemia With Mycoplasma Pneumoniae Pneumonia To the Editor.— We read with interest the article by Turtzo and Ghatak, "Acute Hemolytic Anemia With Mycoplasma Pneumoniae Pneumonia (236:1140, 1976). In our view there are serious questions regarding the type of autoantibody causing hemolysis in the patient presented. Although the direct Coombs' test was positive, no attempts were made to use monospecific Coombs' sera (anti-IgG, anti-C') to characterize the red cell surface proteins. In addition, there were no attempts to elute an antibody from the patient's cells. These determinations are critical if one hopes either to classify the antibody causing hemolysis or to identify it specifically. The indirect Coombs' test revealed both anti-c and anti-e activity. If these antibodies were indeed present and are assumed to be alloantibodies, the patient's Rh phenotype would be CCdEE or CCDEE. Both phenotypes are quite uncommon (in a white population, less than 1/100,000).1 To resolve this problem, the patient's phenotype should http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Hemolytic Anemia With Mycoplasma Pneumoniae Pneumonia

JAMA , Volume 238 (8) – Aug 22, 1977

Hemolytic Anemia With Mycoplasma Pneumoniae Pneumonia

Abstract



To the Editor.—
We read with interest the article by Turtzo and Ghatak, "Acute Hemolytic Anemia With Mycoplasma Pneumoniae Pneumonia (236:1140, 1976).
In our view there are serious questions regarding the type of autoantibody causing hemolysis in the patient presented.
Although the direct Coombs' test was positive, no attempts were made to use monospecific Coombs' sera (anti-IgG, anti-C') to characterize the red cell surface proteins. In addition, there were no...
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References (1)

Publisher
American Medical Association
Copyright
Copyright © 1977 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1977.03280090018008
Publisher site
See Article on Publisher Site

Abstract

To the Editor.— We read with interest the article by Turtzo and Ghatak, "Acute Hemolytic Anemia With Mycoplasma Pneumoniae Pneumonia (236:1140, 1976). In our view there are serious questions regarding the type of autoantibody causing hemolysis in the patient presented. Although the direct Coombs' test was positive, no attempts were made to use monospecific Coombs' sera (anti-IgG, anti-C') to characterize the red cell surface proteins. In addition, there were no attempts to elute an antibody from the patient's cells. These determinations are critical if one hopes either to classify the antibody causing hemolysis or to identify it specifically. The indirect Coombs' test revealed both anti-c and anti-e activity. If these antibodies were indeed present and are assumed to be alloantibodies, the patient's Rh phenotype would be CCdEE or CCDEE. Both phenotypes are quite uncommon (in a white population, less than 1/100,000).1 To resolve this problem, the patient's phenotype should

Journal

JAMAAmerican Medical Association

Published: Aug 22, 1977

There are no references for this article.